Chikungunya disease with nephritic presentation

Solanki, B. S.; Arya, Subhash C.; Maheshwari, P.

doi:10.1111/j.1742-1241.2007.01329.x

Cited by 23 publications

(17 citation statements)

References 3 publications

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“…Blood test abnormalities such as leukopenia, thrombocytopenia, hypocalcemia, and a mild-to-moderate increase in liver function-determining values are seen during acute infection 88, 99. Other uncommon manifestations have also been observed, such as nephritis, 100 meningoencephalitis, 101 encephalopathy, 102 Guillain–Barré syndrome, acute flaccid paralysis, and palsies 103, 104, 105. However, neurologic, ophthalmologic, and hemorrhagic diseases associated with CHIKV infection appear to be rare 106 …”

Section: Alphavirusmentioning

confidence: 99%

Mosquito-transmitted viruses – the great Brazilian challenge

Mota

Terzian

Silva

et al. 2016

Brazilian Journal of Microbiology

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Arboviruses pose a serious threat to public health worldwide, overloading the healthcare system and causing economic losses. These viruses form a very diverse group, and in Brazil, arboviruses belonging to the families Flaviviridae and Togaviridae are predominant. Unfortunately, the number of arboviruses increases in proportion with factors such as deforestation, poor sanitation, climate changes, and introduction of new viruses like Chikungunya virus and Zika virus.In Brazil, dengue is endemic, along with the presence of other arboviruses. The situation is complicated by the scarcity of diagnostic infrastructure and the absence of approved vaccines for these diseases. Disease control, thus, relies solely on vector control. Therefore, enhanced clinical knowledge and improved general awareness about these arboviruses are indispensable to tackle diagnostic inadequacies.

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Section: Alphavirusmentioning

confidence: 99%

Mosquito-transmitted viruses – the great Brazilian challenge

Mota

Terzian

Silva

et al. 2016

Brazilian Journal of Microbiology

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“…Clinical features are characterized by symptoms such as fever, headache, rash, and arthralgia, which may last for days, whereas in some cases, chronic arthritis may persist for years. Atypical clinical complications such as acute nephritis, severe acute hepatitis, and meningoencephalitis have also been reported from recent outbreaks (13)(14)(15)(16).…”

Section: Hikungunya Virus (Chikv) Is the Causative Agent Formentioning

confidence: 99%

Active Infection of Human Blood Monocytes by Chikungunya Virus Triggers an Innate Immune Response

Her

Malleret

Chan

et al. 2010

The Journal of Immunology

253

254

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Chikungunya virus (CHIKV) is an alphavirus that causes chronic and incapacitating arthralgia in humans. To date, interactions between the immune system and the different stages of the virus life cycle remain poorly defined. We demonstrated for the first time that CHIKV Ags could be detected in vivo in the monocytes of acutely infected patients. Using in vitro experimental systems, whole blood and purified monocytes, we confirmed that monocytes could be infected and virus growth could be sustained. CHIKV interactions with monocytes, and with other blood leukocytes, induced a robust and rapid innate immune response with the production of specific chemokines and cytokines. In particular, high levels of IFN-α were produced rapidly after CHIKV incubation with monocytes. The identification of monocytes during the early phase of CHIKV infection in vivo is significant as infected monocyte/macrophage cells have been detected in the synovial tissues of chronically CHIKV-infected patients, and these cells may behave as the vehicles for virus dissemination. This may explain the persistence of joint symptoms despite the short duration of viremia. Our results provide a better understanding on the basic mechanisms of infection and early antiviral immune responses and will help in the development of future effective control strategies.

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“…Other classical symptoms of CHIKV infection include febrile illness (temperature usually .38.9˚C), maculopapular rashes, myalgia, headache, edema of the extremities, and gastrointestinal complaints (10,11). In some cases, CHIKV complications, such as acute nephritis (12), myocarditis, pericarditis (13), myopericarditis (14), retrobulbar neuritis (15), neurologic complications, and death, have also been reported (16,17).…”

mentioning

confidence: 99%

A Pathogenic Role for CD4+ T Cells during Chikungunya Virus Infection in Mice

Teo

Lum

Claser

et al. 2013

The Journal of Immunology

204

277

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Chikungunya virus (CHIKV) is an alphavirus that causes chronic and incapacitating arthralgia in humans. Injury to the joint is believed to occur because of viral and host immune-mediated effects. However, the exact involvement of the different immune mediators in CHIKV-induced pathogenesis is unknown. In this study, we assessed the roles of T cells in primary CHIKV infection, virus replication and dissemination, and virus persistence, as well as in the mediation of disease severity in adult RAG2−/−, CD4−/−, CD8−/−, and wild-type CHIKV C57BL/6J mice and in wild-type mice depleted of CD4+ or CD8+ T cells after Ab treatment. CHIKV-specific T cells in the spleen and footpad were investigated using IFN-γ ELISPOT. Interestingly, our results indicated that CHIKV-specific CD4+, but not CD8+, T cells are essential for the development of joint swelling without any effect on virus replication and dissemination. Infection in IFN-γ−/− mice demonstrated that pathogenic CD4+ T cells do not mediate inflammation via an IFN-γ–mediated pathway. Taken together, these observations strongly indicate that mechanisms of joint pathology induced by CHIKV in mice resemble those in humans and differ from infections caused by other arthritogenic viruses, such as Ross River virus.

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Chikungunya disease with nephritic presentation

Cited by 23 publications

References 3 publications

Mosquito-transmitted viruses – the great Brazilian challenge

Mosquito-transmitted viruses – the great Brazilian challenge

Active Infection of Human Blood Monocytes by Chikungunya Virus Triggers an Innate Immune Response

A Pathogenic Role for CD4+ T Cells during Chikungunya Virus Infection in Mice

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