Chikungunya Virus Pathogenesis and Immunity

Gasque, Philippe; Couderc, Thérèse; Lecuit, Marc; Roques, Pierre; Ng, Lisa F. P.

doi:10.1089/vbz.2014.1710

Cited by 63 publications

(64 citation statements)

References 107 publications

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“…Animal models for CHIKV infection, including mice and non-human primates have been used to study CHIKV-associated pathologies [38]. A zebrafish animal model has also been developed and used to visualize CHIKV infection and innate host responses to infection [94].…”

Section: Experimental Chikv Infection In Animal Models Mimicking Somementioning

confidence: 99%

Chikungunya virus pathogenesis: From bedside to bench

Couderc

Lecuit

2015

Antiviral Research

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Chikungunya virus (CHIKV) is an arbovirus transmitted to humans by mosquito bite. A decade ago, the virus caused a major outbreak in the islands of the Indian Ocean, then reached India and Southeast Asia. More recently, CHIKV has emerged in the Americas, first reaching the Caribbean and now extending to Central, South and North America. It is therefore considered a major public health and economic threat. CHIKV causes febrile illness typically associated with debilitating joint pains. In rare cases, it may also cause central nervous system disease, notably in neonates. Joint symptoms may persist for months to years, and lead to arthritis. This review focuses on the spectrum of signs and symptoms associated with CHIKV infection in humans. It also illustrates how the analysis of clinical and biological data from human cohorts and the development of animal and cellular models of infection has helped to identify the tissue and cell tropisms of the virus and to decipher host responses in benign, severe or persistent disease. This article forms part of a symposium in Antiviral Research on "Chikungunya discovers the New World".

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Section: Experimental Chikv Infection In Animal Models Mimicking Somementioning

confidence: 99%

Chikungunya virus pathogenesis: From bedside to bench

Couderc

Lecuit

2015

Antiviral Research

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“…Then, the mosquito can transmit the virus in each feeding for the rest of its lifetime. To date, there has been no consistent evidence of transovarial transmission in the vectors 26 .…”

Section: Transmission Of Chikvmentioning

confidence: 99%

“…With less frequency, the virus can affect the liver or cause encephalopathy, encephalitis, myocarditis, and heart blockage 27 . Although 5-15% of individuals suffer from asymptomatic infection 26 , the rest generally develop symptoms that progress from the acute to the chronic phase 25 .…”

Section: Clinical Presentationsmentioning

confidence: 99%

“…However, neurological manifestations have been reported that include febrile convulsions, meningeal syndrome, acute encephalopathy, diplopia, aphasia, acute disseminated encephalomyelitis, and encephalitis 35,[38][39][40] . The development of chronic arthralgia and exacerbation of underlying medical conditions is unusual 26 .…”

Section: Acute Phasementioning

confidence: 99%

“…Infection with CHIKV has been associated with destructive rheumatoid arthritis, which is similar to rheumatoid arthritis and induces a similar inflammatory response, although the laboratory tests are negative for the rheumatoid factor and the antibodies for cyclic citrullinated peptides (CCP) 26,44,50 . Radiographic studies of some of these individuals show bone erosion, swollen joints and synovitis 44,51 .…”

Section: Chronic Phasementioning

confidence: 99%

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Chikungunya: Molecular Aspects, Clinical Outcomes and Pathogenesis

Bautista-Reyes

Núñez-Avellaneda

Alonso-Palomares

et al. 2017

RIC

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The alarming worldwide emergence of the chikungunya virus began in the last decade. Since the first autochthonous transmission in Mexico in November of 2014, the virus has spread throughout the country, resulted in multiple outbreaks. This virus produces an acute and self-limiting disease characterized by fever, polyarthralgia, myalgia, exanthema, and general malaise. It is transmitted to humans by the bite of Aedes aegypti and A. albopictus mosquitoes. The fact that the clinical presentation is similar to that produced by other arboviruses complicates its clinical diagnosis. The chronic stage of the disease can cause severe consequences lasting months or years, from local arthralgia to rheumatoid arthritis. In this review, we emphasize the public health threat posed by this highly disabling emerging disease, the clinical outcomes, and its possible physiopathological process. We outline the diagnosis and the impact that this virus has had in Mexico since its introduction.

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Chikungunya Arthritis Mechanisms in the Americas

Chang

Martins

Encinales³

et al. 2018

Arthritis & Rheumatology

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This is one of the largest observational studies involving analysis of the synovial fluid of chikungunya arthritis patients. Synovial fluid analysis revealed no detectable chikungunya virus. This finding suggests that chikungunya virus may cause arthritis through induction of potential host autoimmunity, suggesting a role for immunomodulating agents in the treatment of chikungunya arthritis, or that low-level viral persistence exists in synovial tissue only and is undetectable in synovial fluid.

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Chikungunya Virus Pathogenesis and Immunity

Cited by 63 publications

References 107 publications

Chikungunya virus pathogenesis: From bedside to bench

Chikungunya virus pathogenesis: From bedside to bench

Chikungunya: Molecular Aspects, Clinical Outcomes and Pathogenesis

Chikungunya Arthritis Mechanisms in the Americas

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