Childhood acute glomerulonephritis in Port Harcourt, Rivers State, Nigeria

Anochie, Ifeoma; Eke, Felicia U.; Okpere, AN

doi:10.4314/njm.v18i2.45056

Cited by 7 publications

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“…1). The average annual incidence found in this study is similar to the finding of 8 and 10 per annum by Ladapo et al from Lagos (2012) 24 and Olowu from Ile-Ife (2002) 25 respectively, both from Southwest Nigeria as Ibadan but less than 15.5 per annum by Anochie and Eke 5 and much less than the 50 cases/annum and 30 cases/annum reported from Zaria in the northern part of Nigeria 26 and from Enugu, Southeast Nigeria respectively. 27 It should however be noted that the last two referred studies were carried out over 2 decades ago.…”

Section: Discussionsupporting

confidence: 91%

“…38 but differed from the report by Olowu 26 whose patients were majorly below 6 years of age with a peak age incidence of 3 years. Ibadin and Abiodun 3 from South-south Nigeria in 2003 and Bhalla et al 17 from India in a more recent article also reported a lower peak age incidence The male preponderance in this study is similar to find-ing from most other studies conducted in Nigeria 27,4,5,28,38,9,30 and outside Nigeria. 16,35,36 [36-] Specifically, the male to female ratio of 1.8:1 is similar to findings of studies conducted in Asaba, and Umuahia, Nigeria 8,9 and in India.…”

Section: Discussionsupporting

confidence: 87%

“…Acute glomerulonephritis (AGN) is one of the oldest and most common non-suppurative renal disease conditions seen in childhood. It is a common cause of childhood morbidity and mortality in low and middle income countries (LMICs) [1][2][3][4][5][6][7][8][9][10] AGN could arise as a primary renal disorder, 11,12 or could be secondary to a systemic disease. 13 Acute post-streptococcal glomerulonephritis (APSGN) is the prototype of AGN but a sub-set of acute post-infectious glomerulonephritis (APIGN) which is mostly caused by group A β -hemolytic streptococcus, but could be caused by any infectious agent (bacteria, virus, fungal, parasite).…”

Section: Introductionmentioning

confidence: 99%

“…16 It has indeed been stated that APIGN in high-income countries is predominantly a disease of the adults with risk factors inclusive of diabetes mellitus, malignancy, alcoholism, human immunodeficiency viral (HIV) infection and intravenous drug use. 11,16 The epidemiology of APIGN therefore varies across countries; 1,4,5,8,17,18 and in Nigeria has varied between different geographical locations and may be higher than usually documented as the clinical presentation of APIGN varies from a benign asymptomatic condition (not requiring hospital management) to rapidly progressive glomerulonephritis requiring dialysis. 11 In most parts of the developing world, Nigeria inclusive, paediatric cases of AGN are largely associated with streptococcal infection of the throat and skin, a situation closely linked to low socio-economic status and poor environmental hygiene.…”

Section: Introductionmentioning

confidence: 99%

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Childhood acute glomerulonephritis in Ibadan Nigeria

Asinobi¹,

Ademola²,

Nwankwo³

2020

Nig. J. Paed.

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Background: Acute glomerulonephritis (AGN) is an important cause of mortality and morbidity in children in developing countries while its incidence has declined in the developed world. This study was to document its present impact in our setting.Aim: To evaluate the sociodemographic features and clinical outcomes in children hospitalized for AGN in the Paediatric Nephrology Unit of the University College Hospital, Ibadan.Subjects and Methods: This was a descriptive analytical study of children aged 2 to 14 years admitted with AGN between 2007 and 2019. Their sociodemographic data, clinical features, complications and outcome were analysed.Results: AGN accounted for 116 (8.9%) of new renal cases admitted over the period. Seventy-four (63.8%) were male, mean age (SD) was 8.2 (3.3) years and peak age incidence between 5 and 9 years. Average annual hospital incidence rose from 4-5 new cases to 8-9 new cases/annum with an upsurge to 17 cases in 2019. Highest yearly monthly incidence was between June and December. Forty -five out of 50 (90%) evaluated subjects were in the middle/ low socioeconomic classes. Stage 2 hypertension occurred in 30/50 (60%) with hypertensive crises in 24%. RPGN occurred in 6/50 (12%) of cases accounting for 5 of the 8 dialysed patients and 4 of the 5 deaths. The case fatality rate was 4.3%.Conclusion: The study showed a progressive increase in the hospital incidence of AGN.RPGN was a major risk factor for death in children with AGN and therefore requires a high index of suspicion and an appropriate early intervention. Key words: Childhood, Acute Glomerulonephritis (AGN), Postinfectious AGN, Rapidly progressive glomerulonephritis (RPGN), Hypertensive crises, Outcome

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Childhood acute glomerulonephritis in Ibadan Nigeria

Asinobi¹,

Ademola²,

Nwankwo³

2020

Nig. J. Paed.

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“…10 Port harcourt et al, and Mcgil ugwu et al, reported clustering of cases between October to January. 11,12 The present study was in correlation with the studies of above authors reported from various part of the country. So, it is concluded that most of cases of acute glomerulonephritis occur in rainy and winter seasons.…”

Section: Incidence Of Diseasesupporting

confidence: 88%

Correlation of clinical and laboratory parameters of acute glomerulonephritis in children

Kondapalli

Gondi

Mohammed

2019

Int J Contemp Pediatr

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Background: The present study was conducted to study the clinical and laboratory parameters of acute glomerulonephritis in children admitted in the department of Pediatrics, Katuri Medical College and Hospital, Guntur.Methods: A prospective study was done at Katuri Medical College and Hospital in all children who are clinically diagnosed edema, oliguria, Cola coloured urine and hypertension. Children presenting with Oliguria, Oedema, Haematuria, Hypertension, Pharyngitis or skin lesions were included, both genders male and female. 50 cases of post-streptococcal glomerulonephritis were evaluated by taking detailed history, thorough clinical examination and appropriate investigation were done for establishment of diagnosis. Lab investigations, CUE, RFT, ASO titres, Serum Complement were done. All the statistical analysis was performed by using EPI INFO 3.5-1. The results were expressed as percentages. Test of significance was done by chi square test. P<0.05 was considered significant.Results: 4156 cases were admitted, out of which 50 cases were having acute glomerulonephritis comprising of 1.2%. The incidence of glomerulonephritis was more from July to December. The sex ratio from male to female is 1.17:1. The incidence of glomerulonephritis was more in children coming from low socio-economic families. Signs wise analysis of glomerulonephritis, it was observed that puffiness of face, edema feet and hypertension were the common features. Incidence of hyper tension were more in male children than female children. The incidence of edema and proteinuria are the commonest clinical presentation. The comparison between incidence of oliguria and blood urea is statistically significant. 1/4th of patients of oliguria are associated with increase serum creatinine level.Conclusions: Acute glomerulonephritis is completely a preventable and completely curable disease if proper precaution is like personal hygiene is observed. Proper knowledge of pathophysiology of glomerulonephritis is important for proper management, institution on appropriate treatment and careful follow up of cases are the corner stones for successful outcome of patients.

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A Theoretical and Practical Course on Urine Microscopy in Nigeria: A Model for Nephrological Skill Transfer

et al. 2010

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Background: In the developing world, the diagnostic power of nephrologists is heavily limited by financial, technical and human resource constraints. Urine microscopy (UM) is a basic, inexpensive and relatively simple diagnostic tool, which supplies irreplaceable information. Recently, a theoretical and practical course on UM was organized during the 22nd annual meeting of the Nigerian Society of Nephrology. Methods: The 2-day course was based on power point presentations and on examination of true urine samples by means of a microscope equipped with phase contrast, polarized light and a video camera for projection of the findings. Results: The presentations described were the methodology, the particles of the urine sediment and their clinical interpretation, the urine sediment in different clinical conditions, and 12 clinical cases, which demonstrated the value of UM in clinical practice. Practical sessions showed the most important urine particles, and how they could be identified and combined into urine profiles. More than 97% of the participants found the course to be useful and practicable and a UM program was actually started in 1 Nigerian center a few days after the course. Conclusion: This course demonstrated that nephrological skills can be transferred from the developed to the developing world without large financial investments.

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Childhood acute glomerulonephritis in Port Harcourt, Rivers State, Nigeria

Cited by 7 publications

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Childhood acute glomerulonephritis in Ibadan Nigeria

Childhood acute glomerulonephritis in Ibadan Nigeria

Correlation of clinical and laboratory parameters of acute glomerulonephritis in children

A Theoretical and Practical Course on Urine Microscopy in Nigeria: A Model for Nephrological Skill Transfer

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