Childhood Adversity and the Association Between Stress Sensitivity and Problematic Alcohol Use in Adults

Hall, O.; Phan, K. Luan; Gorka, Stephanie M.

doi:10.1002/jts.22709

Cited by 7 publications

(1 citation statement)

References 83 publications

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“…NPU-threattest ( Wolitzky-Taylor et al, 2014 ; Kreutzer and Gorka, 2021 ; Hall et al, 2022 ; Radoman et al, 2019 )…”

Section: Methodsmentioning

confidence: 99%

How adverse childhood experiences get under the skin: A systematic review, integration and methodological discussion on threat and reward learning mechanisms

Ruge,

Ehlers,

Kastrinogiannis

et al. 2024

eLife

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Adverse childhood experiences (ACEs) are a major risk factor for the development of multiple psychopathological conditions, but the mechanisms underlying this link are poorly understood. Associative learning encompasses key mechanisms through which individuals learn to link important environmental inputs to emotional and behavioral responses. ACEs may impact the normative maturation of associative learning processes, resulting in their enduring maladaptive expression manifesting in psychopathology. In this review, we lay out a systematic and methodological overview and integration of the available evidence of the proposed association between ACEs and threat and reward learning processes. We summarize results from a systematic literature search (following PRISMA guidelines) which yielded a total of 81 articles (threat: n=38, reward: n=43). Across the threat and reward learning fields, behaviorally, we observed a converging pattern of aberrant learning in individuals with a history of ACEs, independent of other sample characteristics, specific ACE types, and outcome measures. Specifically, blunted threat learning was reflected in reduced discrimination between threat and safety cues, primarily driven by diminished responding to conditioned threat cues. Furthermore, attenuated reward learning manifested in reduced accuracy and learning rate in tasks involving acquisition of reward contingencies. Importantly, this pattern emerged despite substantial heterogeneity in ACE assessment and operationalization across both fields. We conclude that blunted threat and reward learning may represent a mechanistic route by which ACEs may become physiologically and neurobiologically embedded and ultimately confer greater risk for psychopathology. In closing, we discuss potentially fruitful future directions for the research field, including methodological and ACE assessment considerations.

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“…NPU-threattest ( Wolitzky-Taylor et al, 2014 ; Kreutzer and Gorka, 2021 ; Hall et al, 2022 ; Radoman et al, 2019 )…”

Section: Methodsmentioning

confidence: 99%

How adverse childhood experiences get under the skin: A systematic review, integration and methodological discussion on threat and reward learning mechanisms

Ruge,

Ehlers,

Kastrinogiannis

et al. 2024

eLife

View full text Add to dashboard Cite

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Emotional Processing and Maltreatment During Childhood as Factors of Vulnerability to Alcohol Abuse in Young Adults

Rubio

Gasparyan

Duque

et al. 2023

Int J Ment Health Addiction

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Different studies suggest a strong association between childhood abuse and alcohol use disorders (AUDs). The modulation of the startle response has been used to assess emotional processing in AUDs. The main objective of the study was to investigate the startle reflex responses to different stimuli in young adults with varying types of childhood abuse in comparison with a control group according to their current alcohol consumption and the presence of a parent with alcohol dependence or not. A clinical sample of 606 adolescents, divided into five groups: no abuse, physical neglect, emotional neglect, emotional abuse, physical abuse, and sexual abuse, were assessed on their pattern of alcohol consumption and their family history of alcoholism. The proportion of participants with at least one alcohol-dependent parent was higher in all types of abuse. The proportion of heavy drinkers and alcohol-dependent participants was higher in the groups with physical neglect and sexual abuse. Heavy drinkers and alcohol dependents showed a lower startle reflex response to emotional pictures, especially alcohol-related ones. Adolescents exposed to physical and sexual abuse during childhood showed a mitigated startle response to appetitive and alcohol-related pictures. The results of this exploratory study reveal that childhood maltreatment modulates emotional processing to alcohol-related stimuli during adolescence. The evaluation of these patients’ startle response could be considered a prognostic biomarker for establishing personalized preventive strategies during the adolescent stage to avoid, to a large extent, future problems derived from alcohol consumption.

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Years of Life Lost to Unintentional Drug Overdose Rapidly Rising in the Adolescent Population, 2016–2020

Hermans

Samiec

Golec

et al. 2023

Journal of Adolescent Health

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Childhood Adversity and the Association Between Stress Sensitivity and Problematic Alcohol Use in Adults

Cited by 7 publications

References 83 publications

How adverse childhood experiences get under the skin: A systematic review, integration and methodological discussion on threat and reward learning mechanisms

How adverse childhood experiences get under the skin: A systematic review, integration and methodological discussion on threat and reward learning mechanisms

Emotional Processing and Maltreatment During Childhood as Factors of Vulnerability to Alcohol Abuse in Young Adults

Years of Life Lost to Unintentional Drug Overdose Rapidly Rising in the Adolescent Population, 2016–2020

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