Childhood Guillain-Barré Syndrome: Clinical and Electrophysiologic Features Predictive of Outcome

Ammache, Zakaria; Afifi, Adel K.; Brown, Charles E.; Kimura, Junko

doi:10.2310/7010.2001.17076

Cited by 3 publications

(4 citation statements)

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“…21 In our population, 47 (11.9%) patients died in the 11-year period; this is higher than reported in previous studies. These two factors, along with a high disability score on presentation, have been described as predictors of poor prognosis.…”

Section: Discussioncontrasting

confidence: 60%

“…18 The incidence of Guillain-Barré syndrome in adults from other countries is much higher, with several studies reporting peaks between 50 and 74 years of age, with an annual incidence of 3.2 cases per 100,000. 8,21 In our patient population, there was no evidence of a statistically significant association with the onset of Guillain-Barré syndrome and the time of year. 19,20 Although the difference in the male-to-female ratio of 1.2:1.0 was statistically significant, this ratio was similar to that found in other studies of childhood Guillain-Barré syndrome.…”

Section: Discussionmentioning

confidence: 53%

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Epidemiology of Childhood Guillain-Barré Syndrome as a Cause of Acute Flaccid Paralysis in Honduras: 1989—1999

et al. 2003

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The objective of this study was to investigate the incidence of acute flaccid paralysis in the pediatric population of Honduras over an 11-year period, determine what percentage of acute flaccid paralysis was Guillain-Barré syndrome, and identify the epidemiologic features of Guillain-Barré syndrome. There were 546 childhood cases of acute flaccid paralysis seen between January 1989 and December 1999 at the Hospital Escuela Materno-Infantil in Tegucigalpa, Honduras. Of these cases with acute flaccid paralysis, 394 (72.2%) were diagnosed with Guillain-Barré syndrome. Our incidence of Guillain-Barré syndrome in the Honduran pediatric population (1.37/100,000 per year) is higher than that shown in other studies. There was a significantly higher incidence of Guillain-Barré syndrome in younger children (ages 1-4 years), a significant preponderance of cases from rural areas, and a mild predominance in boys but a typical clinical presentation. The Honduran pediatric Guillain-Barré syndrome population had an increased mortality rate. Guillain-Barré syndrome has become the leading cause of childhood paralysis in Honduras. A better understanding of the population at highest risk and opportunities for earlier intervention with more effective therapeutic modalities may permit reducing the mortality among Honduran children who develop Guillain-Barré syndrome.

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Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 53%

Epidemiology of Childhood Guillain-Barré Syndrome as a Cause of Acute Flaccid Paralysis in Honduras: 1989—1999

et al. 2003

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“…The AMAN pattern was found in 65%–86% in China,11, 18, 19 30% in Argentina,21 and 35% in Turkey 24. In contrast, a number of reports showed that in North America, most GBS children appear to have AIDP, although these reports did not employ the same electrodiagnostic criteria for AIDP or AMAN as used in this study 1, 3. These findings suggest that the incidence of AMAN in childhood GBS varies considerably among countries, as it does in the adult population.…”

Section: Discussionmentioning

confidence: 53%

Electrophysiological subtypes and prognosis of childhood Guillain–Barré syndrome in Japan

et al. 2006

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Guillain-Barré syndrome (GBS) is classified into acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor axonal neuropathy (AMAN), but little is known about the incidence of the subtypes and the prognosis of childhood GBS. To elucidate the features and long-term prognosis, clinical and electrophysiological data for 31 Japanese GBS children were reviewed. By electrodiagnostic criteria, children were classified as having AIDP (35%) or AMAN (48%), or were unclassified (16%). The AMAN children invariably had normal sensory nerve potentials. Between the two groups, age, sex, and clinical disability did not differ significantly, but the AIDP children more frequently had cranial and sensory nerve involvement, and the AMAN children more frequently had preceding gastroenteritis. By 6 months after onset, all the AIDP and 80% of the AMAN children had regained the ability to walk; by 2 years, all but one of the AMAN children could walk. In Japanese childhood GBS, the proportion of AIDP and AMAN appears to be similar. Recovery is generally favorable in both subtypes, but some of the AMAN children experienced delayed recovery.

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“…The amplitude of the compound muscle action potential (CMAP) assessed by nerve conduction studies provides a prognostic guide in facial nerve lesions7, 10, 25 and Guillain–Barré syndrome,6 although this is not well established in children 1. In patients with facial nerve lesions, an interside asymmetry of CMAP amplitude indicates a poor outcome.…”

mentioning

confidence: 99%

Motor conduction studies for prognostic assessment of obstetrical plexopathy

et al. 2004

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Early prognostic assessment of obstetrical brachial plexopathies (OBP) would facilitate rational selection of infants for brachial plexus surgery. We performed bilateral motor nerve conduction studies (MNCS) of axillary, musculocutaneous, radial, median, and ulnar nerves in 33 babies (age 10-60 days) with OBP in order to compare the amplitude of compound muscle action potentials (CMAPs). All babies were followed up until 6 months of age and the outcome was classified according to muscle strength and arm function. A CMAP amplitude reduction of more than 90%, compared to the unaffected side, predicted severe weakness of the corresponding root level (p < 0.01). Our results indicate that MNCS are a useful tool for very early prognostic assessment of OBP.

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Childhood Guillain-Barré Syndrome: Clinical and Electrophysiologic Features Predictive of Outcome

Cited by 3 publications

References 0 publications

Epidemiology of Childhood Guillain-Barré Syndrome as a Cause of Acute Flaccid Paralysis in Honduras: 1989—1999

Epidemiology of Childhood Guillain-Barré Syndrome as a Cause of Acute Flaccid Paralysis in Honduras: 1989—1999

Electrophysiological subtypes and prognosis of childhood Guillain–Barré syndrome in Japan

Motor conduction studies for prognostic assessment of obstetrical plexopathy

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