Childhood stress impairs social function through AVP-dependent mechanisms

Brydges, Nichola M.; Hall, Jeremy Peter; Best, Caroline; Rule, Lowenna; Watkin, Holly; Drake, Amanda J.; Lewis, Catrin; Thomas, Kerrie L.; Hall, Jérémy

doi:10.1038/s41398-019-0678-0

Cited by 13 publications

(16 citation statements)

References 104 publications

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“…Looking in adulthood, early‐life stress is associated with an increased risk of anti‐social behaviour and borderline personality disorder in humans 171 . Early‐life stress has been linked to social deficits and borderline personality disorder via up‐regulation of AVP in humans and rats 278 …”

Section: Comparing Early‐life Stress and Delivery By Caesarean Sectionmentioning

confidence: 99%

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Birth signalling hormones and the developmental consequences of caesarean delivery

Kenkel

2020

J Neuroendocrinology

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Rates of delivery by caesarean section (CS) are increasing around the globe and, although several epidemiological associations have already been observed between CS and health outcomes in later life, more are sure to be discovered as this practice continues to gain popularity. The components of vaginal delivery that protect offspring from the negative consequences of CS delivery in later life are currently unknown, although much attention to date has focused on differences in microbial colonisation. Here, we present the case that differing hormonal experiences at birth may also contribute to the neurodevelopmental consequences of CS delivery. Levels of each of the ‘birth signalling hormones’ (oxytocin, arginine vasopressin, epinephrine, norepinephrine and the glucocorticoids) are lower following CS compared to vaginal delivery, and there is substantial evidence for each that manipulations in early life results in long‐term neurodevelopmental consequences. We draw from the research traditions of neuroendocrinology and developmental psychobiology to suggest that the perinatal period is a sensitive period, during which hormones achieve organisational effects. Furthermore, there is much to be learned from research on developmental programming by early‐life stress that may inform research on CS, as a result of shared neuroendocrine mechanisms at work. We compare and contrast the effects of early‐life stress with those of CS delivery and propose new avenues of research based on the links between the two bodies of literature. The research conducted to date suggests that the differences in hormone signalling seen in CS neonates may produce long‐term neurodevelopmental consequences.

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Section: Comparing Early‐life Stress and Delivery By Caesarean Sectionmentioning

confidence: 99%

“…171 Early-life stress has been linked to social deficits and borderline personality disorder via up-regulation of AVP in humans and rats. 278 Early life is a sensitive period for the development of social behaviour. Both pre- [279][280][281][282] and postnatal stress 283,284 lead to later life social impairments in rodents and other species.…”

Section: Lowmentioning

confidence: 99%

Birth signalling hormones and the developmental consequences of caesarean delivery

Kenkel

2020

J Neuroendocrinology

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“…Experiences in early life have shown the potential to change social recognition and may lead to neuropsychiatric disorders, including ASD ( Tabbaa et al, 2017 ; Brydges et al, 2019 ). As we found earlier, long-term repetitive NMS could cause impairments in social recognition and autistic-like behaviors.…”

Section: Resultsmentioning

confidence: 99%

Involvement of Oxytocin Receptor/Erk/MAPK Signaling in the mPFC in Early Life Stress-Induced Autistic-Like Behaviors

Wei

et al. 2020

Front. Cell Dev. Biol.

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The neonatal or infant period is a critical stage for the development of brain neuroplasticity. Early life stresses in the neonatal period, including neonatal maternal separation (NMS), have adverse effects on an increased risk of psychiatric disorders in juveniles and adults. However, the underlying molecular mechanisms are not largely understood. Here, we found that juvenile rats subjected to 4 h daily NMS during postnatal days 1 to 20 exhibited autistic-like behavioral deficits without impairments in learning and memory functions. Molecular mechanism studies showed that oxytocin receptor (OXTR) in the medial prefrontal cortex of NMS rats was evidently downregulated when compared with control pups, especially in neurons. Erk/MAPK signaling, the downstream coupling signaling of OTXR, was also inhibited in NMS juvenile rats. Treatment with oxytocin could relieve NMS-induced social deficit behaviors and activated phosphorylation of Erk/MAPK signaling. Furthermore, medication with the inhibitor of H3K4 demethylase alleviated the abnormal behaviors in NMS rats and increased the expression of OXTR in the medial prefrontal cortex, which showed an epigenetic mechanism underlying social deficits induced by NMS. Taken together, these findings identified a molecular mechanism by which disruptions of mother–infant interactions influenced later displays of typical social behaviors and suggested the potential for NMS-driven epigenetic tuning of OXTR expression.

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“…Depression, impulsivity, and violence seem causally linked to AVP regardless of other factors, e.g., sex, stressors [ 274 , 275 , 276 , 277 ]. Childhood stress appears to affect sociality through AVP [ 278 ]. Underscoring the complexity of the AVP neural network, the AVP system was found to respond to both gonadal steroids and genetic background (more below), and life history influences the individual responses to specific contexts [ 67 ].…”

Section: Avp and Brain Functionmentioning

confidence: 99%

The Biology of Vasopressin

et al. 2021

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Vasopressins are evolutionarily conserved peptide hormones. Mammalian vasopressin functions systemically as an antidiuretic and regulator of blood and cardiac flow essential for adapting to terrestrial environments. Moreover, vasopressin acts centrally as a neurohormone involved in social and parental behavior and stress response. Vasopressin synthesis in several cell types, storage in intracellular vesicles, and release in response to physiological stimuli are highly regulated and mediated by three distinct G protein coupled receptors. Other receptors may bind or cross-bind vasopressin. Vasopressin is regulated spatially and temporally through transcriptional and post-transcriptional mechanisms, sex, tissue, and cell-specific receptor expression. Anomalies of vasopressin signaling have been observed in polycystic kidney disease, chronic heart failure, and neuropsychiatric conditions. Growing knowledge of the central biological roles of vasopressin has enabled pharmacological advances to treat these conditions by targeting defective systemic or central pathways utilizing specific agonists and antagonists.

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Childhood stress impairs social function through AVP-dependent mechanisms

Cited by 13 publications

References 104 publications

Birth signalling hormones and the developmental consequences of caesarean delivery

Birth signalling hormones and the developmental consequences of caesarean delivery

Involvement of Oxytocin Receptor/Erk/MAPK Signaling in the mPFC in Early Life Stress-Induced Autistic-Like Behaviors

The Biology of Vasopressin

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