Childhood thyroid autoimmunity and relation to islet autoantibodies in children at risk for type 1 diabetes in the diabetes prediction in skåne (DiPiS) study

Jonsdottir, Berglind; Larsson, Christer; Lundgren, Markus; Ramelius, Anita; Jönsson, Ida; Larsson, Helena Elding

doi:10.1080/08916934.2018.1519027

Cited by 18 publications

(16 citation statements)

References 48 publications

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“…In our study, we found vital correspondence between the presence of GADA antibodies and both clinically manifested thyroid AD and asymptomatic thyroid autoimmunity. Our results are consistent with previously published data (39,43). Glutamic acid decarboxylase antibodies are found in ∼70-80% of patients who suffer from T1DM, long before the onset of clinical symptoms, and they remain positive over a long time after.…”

Section: Discussionsupporting

confidence: 93%

“…Our results are consistent with existing studies that notice thyroid autoimmunity more often in girls (33,39) and increase by 4.6% in prevalence of hypothyroidism (including subclinical cases) for every 10-year increase of age in T1D and with diabetes duration (15). These findings correlate with overall trends of thyroid autoimmunity incidence in other countries (39,40) and also in Poland (41). Contrary to our findings, the meta-analysis based on 14 studies shows that the risk of thyroid dysfunction is much higher in children in comparison to adults (42).…”

Section: Discussionsupporting

confidence: 93%

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Increasing Co-occurrence of Additional Autoimmune Disorders at Diabetes Type 1 Onset Among Children and Adolescents Diagnosed in Years 2010–2018—Single-Center Study

et al. 2020

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Objectives: The prevalence of type 1 diabetes mellitus (T1D) in children is growing, but its relation to other autoimmune disorders that coexist since the onset of diabetes is not recognized. The objective of this study was to assess the incidence of T1D and the prevalence of autoimmune illnesses additionally coexisting since the diabetes mellitus onset in children during a period of 9 years' observation. Methods: In this retrospective study, the incidence rate (IR) of the T1D was calculated as the total number of all cases that were newly diagnosed per 100,000 population people between 0 and 18 years of age. The selected age groups (0-4, 5-9, 10-14, and 15-18 years) were examined, respectively. The studied group included 493 children (264 [53.55%] boys) between 0 and 18 years old newly diagnosed with T1D in one of the Polish centers in the years 2010-2018. Other autoimmune illnesses diagnoses were obtained from medical records taken from the first hospital treatment, when T1D was recognized. Results: The annual standardized IR of T1D increased from 19.2/100,000 in year 2010 to 31.7/100,000 in 2018 (1.7-fold over 9 years' observation), with an increase in the incidence rate ratio (IRR) by 4% per year. The highest growth in IR was recorded in 5-to 9-year-olds (from 19.61 in 2010 to 43.45 in 2018). In 61 (12.4%) of the studied group, at least one additional autoimmune disease was diagnosed. The prevalence doubled from 10.4% in the year 2010 to 20.8% in the year 2018. Autoimmune thyroid illnesses were found in 37 children (7.5%); their incidence increased from 6.3% to almost 2-fold, 12.5%, in 2018. In 26 children (5.3%), celiac disease was recognized; the prevalence increased from 4.2 to 9.8% in the study period. The prevalence of additional autoimmune thyroid disease was higher in glutamic acid decarboxylase-positive antibodies (χ 2 = 3.4, p = 0.04) patients, the oldest age group (15-18 years) (χ 2 =7.1, p = 0.06), and in girls (χ 2 =7.1, p = 0.007). Głowińska-Olszewska et al. Autoimmune Comorbidities in T1D Children Conclusions: The standardized IR of T1D in children increased 1.7-fold over the 9-year observation period, and IRR increased 4% per year. Additional autoimmunity represents a significant comorbidity in patients with new-onset T1D. The number of children diagnosed with additional autoimmune diseases that accompany T1D is rapidly growing in all age groups throughout recent years.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Increasing Co-occurrence of Additional Autoimmune Disorders at Diabetes Type 1 Onset Among Children and Adolescents Diagnosed in Years 2010–2018—Single-Center Study

et al. 2020

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“… 20 Furthermore, a higher proportion of patients with T1DM positive for pancreatic islet beta-cell antibodies, insulin antibodies, and antiglutamic acid decarboxylase antibodies (GADAbs), which are often used for the diagnosis of T1DM, have been found to be positive for TPOAb. 5 , 21 – 27 Therefore, it is considered that AITD is the most prevalent T1DM-related autoimmune disease, whereas LADA is an independent risk factor for the development of AITD. 5 , 6 , 8 , 18 , 28 – 32 …”

Section: Introductionmentioning

confidence: 99%

Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective?

Li¹,

Liu

2020

Therapeutic Advances in Endocrinology

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Autoimmune thyroid disease (AITD) and type 1 diabetes mellitus (T1DM) are two common autoimmune diseases that can occur concomitantly. In general, patients with diabetes have a high risk of AITD. It has been proposed that a complex genetic basis together with multiple nongenetic factors make a variable contribution to the pathogenesis of T1DM and AITD. In this paper, we summarize current knowledge in the field regarding potential pathogenic factors of T1DM and AITD, including human leukocyte antigen, autoimmune regulator, lymphoid protein tyrosine phosphatase, forkhead box protein P3, cytotoxic T lymphocyte-associated antigen, infection, vitamin D deficiency, and chemokine (C-X-C motif) ligand. These findings offer an insight into future immunotherapy for autoimmune diseases.

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“…Collectively, these findings indicate that Chinese T1DM patients are also prone to other organ-specific autoimmune diseases, presumably related to the expansion of antibody recognition epitopes among different antigen molecules. Although previous studies have found that patients positive for IA-2A are at higher risk of thyroid dysfunction [26], there have been no reports that IA-2A-positive T1DM patients are more likely to be positive for thyroid antibodies. We found that patients positive for GADA or IA-2A were more likely to exhibit positivity for TPOA or TGA, suggesting that those patients are prone to develop comorbid thyroid autoimmune diseases.…”

Section: Discussionmentioning

confidence: 90%

Organ-specific autoantibodies in Chinese patients newly diagnosed with type 1 diabetes mellitus

Pan

Shi

et al. 2020

Endocr J

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This study aims to investigate the prevalence of islet autoantibodies and other organ-specific autoantibodies in type 1 diabetes mellitus (T1DM) patients and characterize their clinical features. Glutamic acid decarboxylase antibody (GADA), insulinoma antigen 2 antibody (IA-2A), zinc transporter 8 antibody (ZnT8A) and tetraspanin7 antibody (TSPAN7A) were assayed by radioligand or luciferase immunoprecipitation system assays in 205 newly diagnosed acute-onset T1DM patients and 170 healthy controls. Other organ-specific autoantibodies, including thyroid peroxidase antibody (TPOA), thyroglobulin antibody (TGA), tissue transglutaminase antibody (tTGA) and 21-hydroxylase antibody (21-OHA), were also measured. The prevalence of GADA, IA-2A, ZnT8A, TSPAN7A, TPOA, TGA and 21-OHA was higher in T1DM patients than in healthy controls. The combinational assay of various islet autoantibodies could increase the frequency of autoantibody positivity in T1DM to 85.4%. GADA+ IA-2A+ T1DM patients preferentially had TPOA and TGA, while IA-2A+ patients often had tTGA. Patients positive for two or more islet autoantibodies often had TPOA and TGA. BMI of multiple islet autoantibodypositive patients was lower than that of patients with single or no islet autoantibodies, and there were no significant differences in C-peptide and glycated hemoglobin between patients positive for islet autoantibodies combined with other organ-specific antibodies and noncombined patients. Younger female patients who were islet autoantibody positive were more likely to have TPOA and TGA. The frequency of Graves' disease was much higher in T1DM patients than in healthy controls. T1DM usually occurs together with other organ-specific autoantibodies. Measuring of other organ-specific autoantibodies will be beneficial for T1DM patients.

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Childhood thyroid autoimmunity and relation to islet autoantibodies in children at risk for type 1 diabetes in the diabetes prediction in skåne (DiPiS) study

Abstract: Larsson & the DiPiS study Group (2018) Childhood thyroid autoimmunity and relation to islet autoantibodies in children at risk for type 1 diabetes in the diabetes prediction in

Cited by 18 publications

References 48 publications

Increasing Co-occurrence of Additional Autoimmune Disorders at Diabetes Type 1 Onset Among Children and Adolescents Diagnosed in Years 2010–2018—Single-Center Study

Increasing Co-occurrence of Additional Autoimmune Disorders at Diabetes Type 1 Onset Among Children and Adolescents Diagnosed in Years 2010–2018—Single-Center Study

Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective?

Organ-specific autoantibodies in Chinese patients newly diagnosed with type 1 diabetes mellitus

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