Childhood trauma interacted with BDNF Val66Met influence schizophrenic symptoms

Abstract

The gene – environment (G × E) interaction effect is involved in severe mental disorders. However, whether the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism participates in the childhood-abuse influenced schizophrenic symptoms remains unclear. We examined the interaction between BDNF Val66Met, and childhood trauma (ChT) on psychotic symptoms in a Chinese Han population.To estimate the G × E interaction, psychiatric interviews, self-report questionnaires for ChT, and genotyping for BDNF Val66Met were carried out on 201 schizophrenic patients. G × E interactions were analyzed by generalized multifactor dimensionality reduction (GMDR).Among all patients, 11.9%, 19.4%, 23.4%, 26.4%, and 73.6% reported emotional abuses, physical abuses (PA), sexual abuses (SA), emotional neglects (EN), and physical neglects (PN), respectively. Significant negative correlations were observed between anxiety/depression factors, and ChT total scores. Patients with 3 different BDNF genotypes showed significant differences in anxiety/depression scores. Significant 2-way interactions were found for Val66Met × PN, 3-way interactions were found for Val66Met × PN × PA, and four-way interactions were found for Val66Met × PN × PA × EN with regard to the excitement scores.Our findings suggested an involvement of BDNF Val66Met polymorphism after ChT in terms of risk for schizophrenia symptoms.

The Role of Childhood Trauma in Psychosis and Schizophrenia: A Systematic Review

“…ChT is probably the most important environmental factor associated with SCZ [ 20 ]. There is evidence of multiple paths between traumatic experiences and psychosis.…”

“…Research has also shown that the genetic factor brain-derived neurotrophic factor (BDNF) Val66Met polymorphism directly connects to SCZ symptoms, in addition to the interplay of genes and environmental factors, especially ChT. When exposed to ChT, BDNF Met carriers have increased positive psychotic experiences compared to their counterparts [ 20 ].…”

Novel biomarkers to assess in utero effects of maternal opioid use: First steps toward understanding short‐ and long‐term neurodevelopmental sequelae

“…56 Although we do not wish to over interpret our results, we will have not yet been validated in the literature also show involvement in the pathogenesis of neurodevelopmental disorders (SLC9A6, 84,85 PPP1R15B 86 are associated with intellectual disability 87 ). 95 Overall, our findings indicate that changes in miRNA expression driven by in utero opioid exposure could play an important role in regulating the expression of genes associated with developmental disorders and psychiatric diseases during critical stages of embryonic development. BDNF is a validated target of miR 10b-5p 88 and miR10a-5p 89,90 that is involved in the pathogenesis of alcohol abuse, 89,91 opioid use 92,93 and cocaine use, 94 Huntington's disease 88 and schizophrenia.…”

“…BDNF is a validated target of miR 10b-5p 88 and miR10a-5p 89,90 that is involved in the pathogenesis of alcohol abuse, 89,91 opioid use 92,93 and cocaine use, 94 Huntington's disease 88 and schizophrenia. 95 Overall, our findings indicate that changes in miRNA expression driven by in utero opioid exposure could play an important role in regulating the expression of genes associated with developmental disorders and psychiatric diseases during critical stages of embryonic development.…”

rs1344706 polymorphism of zinc finger protein 804a (ZNF804a) gene related to the integrity of white matter fiber bundle in schizophrenics

“…The onset age of SZ is early and the disease has a chronic progression (3). Progressive aggravation or deterioration, accompanied by social dysfunction along with high disability rate and death rate can create a great burden to the society (4). At present, the pathogenesis of SZ is unclear, however results obtained from prior studies have revealed that genetic factors play an important role in the pathogenesis of SZ (5,6).…”