Childhood urticaria

Abstract

Urticaria is a common disease that affects children and adults. However, paediatric urticaria has specific features and remains poorly understood. Acute spontaneous urticaria is the most common clinical presentation in childhood. It is caused by viral infection in most cases with an identifiable trigger. By contrast, chronic spontaneous urticaria in children may be autoimmune, but more studies are needed to understand the clinical significance of functional autoantibodies in this subgroup of patients. Investigations should always be guided by history. Treatment remains largely symptomatic. H1-antihistamines are the mainstay of therapy but are insufficient to control symptoms in all patients. There is an urgent need for more efficacious therapies.

Controversies and challenges in the management of chronic urticaria

“…Studies of improvement with dietary intervention are not available. Few studies have been carried out in children suffering from urticaria and as a result the impact of urticaria on quality of life in children remains unknown . As such, there is considerable unmet need for treating/managing childhood urticaria.…”

Current status of therapy with omalizumab in children

“…Chronic urticaria in children may be autoimmune in its origin, and clinical significance of autoantibodies in this subgroup of patients deserves further elucidation [26]. Chronic urticaria in children may be autoimmune in its origin, and clinical significance of autoantibodies in this subgroup of patients deserves further elucidation [26].…”

Chronic Urticarial in Childhood. Immune Pathology of Chronic Urticarial in Children (Part I)

“…В детском возрасте установлена более частая хронизация крапивницы при на-личии сопутствующих инфекций, которые так-же рассматриваются и как триггеры обострений [59]. Их выявляемость достигает 35% среди детей с данной патологией [76] Наиболее часто выявляемыми инфекциями у детей, страдающих хронической крапивницей, являются инфекции урогенитального тракта, вы-званные Е. соli [15], дыхательных путей, обуслов-ленные С. pneumoniae, Streptococcus pyogenes [25], вирусные заболевания, такие как инфекционный мононуклеоз ВЭБ-этиологии и цитомегалови-русная инфекция [61], хеликобактерная инфек-ция [7], паразитарные инвазии [1].…”