Children hospitalized with severe malaria in Kinshasa (Democratic Republic of the Congo): Household characteristics and factors associated with mortalitys

Ilunga-Ilunga, Félicien; Lévêque, Alain; Donnen, Philippe; Dramaix, Michèle

doi:10.1684/mst.2014.0416

Cited by 3 publications

(14 citation statements)

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“…Like in previous studies carried out [ 12 , 27 , 28 , 37 ], this research shows that severe acute malnutrition was significally and independently associated to death risk during malaria. This result confirms the idea sustaining that malnutrition stands as a base to pediatric tropical pathology.…”

Section: Discussionsupporting

confidence: 85%

“…This result confirms the idea sustaining that malnutrition stands as a base to pediatric tropical pathology. There often exist a risk cumulation since in these contries, malnutrition is frequently associted to anemia and digestive parasitolosis [ 27 , 37 ]. The reduction of malaria letalily requires a better health care management of the pathologies or the reduction of their transmission.…”

Section: Discussionmentioning

confidence: 99%

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Severe malaria and death risk factors among children under 5 years at Jason Sendwe Hospital in Democratic Republic of Congo

Mutombo¹,

Mukuku²,

Tshibanda³

et al. 2018

Pan Afr Med J

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IntroductionMalaria is still a major public health concern in the Democratic Republic of Congo. Its morbidity and mortality challenge the actual strategies of the fight agains malaria. This study was aimed to describe the epidemiology, the clinical caracteristics and the risk factors of death associated to severe malaria in the pediatric population under 5 years at Sendwe Hospital of Lubumbashi.MethodsThis analytical retrospective study was conducted in Lubumbashi, in the province of Haut-Katanga. All patients under 5 years hospitalized for severe malaria were registered from January 2014 to December 2016.ResultsAmong the 3,092 patients hospitalised during our study period, 452 (14.6%) were admitted for severe malaria. The average age was 27.04 months, the male sex was the most affected (53.54% with the sex-ratio 1.15). The most frequent forms of gravity noticed were cerebral malaria (48.23%) and severe anemia (46.90%). Death was noted in the evolution in 28.32%. Repeated convulsion (OR = 2.27; 95% CI: 1.47-3.48), coma (OR = 3.55; 95% CI: 2.19-5.74) and severe acute malnutrition (OR = 3.32; 95% CI: 1.56-7.06) were asscociated with a high risk of death.ConclusionThis research shows that severe malaria is still an important cause of morbidity and mortality among young children in Lubumbashi. Neurologic and anemic forms are the most frequent. The predictive signs of death are: repeated convulsions, coma and severe acute malnutrition.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Severe malaria and death risk factors among children under 5 years at Jason Sendwe Hospital in Democratic Republic of Congo

Mutombo¹,

Mukuku²,

Tshibanda³

et al. 2018

Pan Afr Med J

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“…People are at risk of acquiring malaria infection due to factors related to environment, demographics, socioeconomic status, and exposure to prevention interventions [6,[11][12][13][14][15][16][17][18].…”

Section: Malaria Risk Factors and Those Most-at-risk For Malariamentioning

confidence: 99%

“…Some studies have analyzed trends in the prevalence of malaria infection among under-five children at the national and sub-national (province, district, and health zone) levels [11,12]. Others have described socioeconomic factors associated with malaria morbidity and mortality among patients attending health facilities [13][14][15]. Some other studies have analyzed individual and community socioeconomic factors associated with malaria infection [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

“…The most-at-risk groups for malaria infection could be a result of different interactions between malaria risk factors. For instance, existing literature revealed that children living in poorest households, children of less-educated mothers, children living in rural areas, and children aged above 23 months had greater risk of malaria infection [13][14][15][16][17][18]. However, a child could belong to all these risk categories, or could belong to the least risk groups and high risk groups at the same time [8].…”

Section: Introductionmentioning

confidence: 99%

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Profiling malaria infection among under-five children in the Democratic Republic of Congo

2021

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Introduction In 2018, Malaria accounted for 38% of the overall morbidity and 36% of the overall mortality in the Democratic Republic of Congo (DRC). This study aimed to identify malaria socioeconomic predictors among children aged 6–59 months in DRC and to describe a socioeconomic profile of the most-at-risk children aged 6–59 months for malaria infection. Materials and methods This study used data from the 2013 DRC Demographic and Health Survey. The sample included 8,547 children aged 6–59 months who were tested for malaria by microscopy. Malaria infection status, the dependent variable, is a dummy variable characterized as a positive or negative test. The independent variables were child’s sex, age, and living arrangement; mother’s education; household’s socioeconomic variables; province of residence; and type of place of residence. Statistical analyses used the chi-square automatic interaction detector (CHAID) model and logistic regression. Results Of the 8,547 children included in the sample, 25% had malaria infection. Four variables—child’s age, mother’s education, province, and wealth index—were statistically associated with the prevalence of malaria infection in bivariate analysis and multivariate analysis (CHAID and logistic regression). The prevalence of malaria infection increases with child’s age and decreases significantly with mother’s education and the household wealth index. These findings suggest that the prevalence of malaria infection is driven by interactions among environmental factors, socioeconomic characteristics, and probably differences in the implementation of malaria programs across the country. The effect of mother’s education on malaria infection was only significant among under-five children living in Ituri, Kasaï-Central, Haut-Uele, Lomami, Nord-Ubangi, and Maniema provinces, and the effect of wealth index was significant in Mai-Ndombe, Tshopo, and Haut-Katanga provinces. Conclusion Findings from this study could be used for targeting malaria interventions in DRC. Although malaria infection is common across the country, the prevalence of children at high risk for malaria infection varies by province and other background characteristics, including age, mother’s education, wealth index, and place of residence. In light of these findings, designing provincial and multisectoral interventions could be an effective strategy to achieve zero malaria infection in DRC.

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Malaria Lethality in Children under 5 Years of Age and Study of Risk Factors in MbujiMayi Paediatric Environment, a Neglected Deadly Epidemic in the Democratic of Republic of Congo

Ilunga-Ilunga¹,

Lévêque²,

Kanyinda³

et al. 2021

Current Topics and Emerging Issues in Malaria Elimination

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The objective of this study was to determine the risk factors for malaria lethality in the MbujiMayi paediatric environment, a follow-up study of hospitalised cases over 5 years was conducted between January 2016 and December 2020 in the four hospitals. The case rate was 6.9% for the total (139 cases of death for 2017 cases of severe malaria for 5 years,) and varied from year to year (10.7% in 2016 to 4.6% in 2020). Cox Proportional Risk Model results including significant covariates in multivariate analysis [HR (IC95%)]. In multivariate analysis, two models were considered. The case-fatality rate was independently associated with late arrival after 48 hours [3.1 (1.9–5.1); p < 0.001], types of pre-hospital recourse such as recourse to the church [1.4 (1.1–2.1),; p = 0.042) and tradipractor [3.2 (1.8–6.1); p < 0.001] for severe malaria, children under 12 months of age [1.8 (1.2–2.8); p < 0.001], those with circulatory collapse [2.6 (1.1–6.1); p < 0.001] and those in deep coma [1.9 (1.1–3.4); p = 0.016]. The second model with the number of associated syndromes, showed that the risk was 1.7 plus for children with a complex clinical picture, made up of the combination of several signs [1.7 (1.1–2.6); p < 0.001]. These results highlight the need for more information campaigns to encourage people to seek institutional care for malaria. Our results also suggest that prophylactic treatment may be advisable for children under 5 years of age.

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Children hospitalized with severe malaria in Kinshasa (Democratic Republic of the Congo): Household characteristics and factors associated with mortalitys

Cited by 3 publications

References 14 publications

Severe malaria and death risk factors among children under 5 years at Jason Sendwe Hospital in Democratic Republic of Congo

Severe malaria and death risk factors among children under 5 years at Jason Sendwe Hospital in Democratic Republic of Congo

Profiling malaria infection among under-five children in the Democratic Republic of Congo

Malaria Lethality in Children under 5 Years of Age and Study of Risk Factors in MbujiMayi Paediatric Environment, a Neglected Deadly Epidemic in the Democratic of Republic of Congo

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