Children of the 90s: Coming of age

Pearson, Helen

doi:10.1038/484155a

Cited by 38 publications

(16 citation statements)

References 13 publications

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“…These are essentially the reasons why 'genomics is not enough': the base sequence of the DNA is necessary, but not sufficient to describe the function of any stretch of DNA. The study of identical twins provides evidence that this accumulation of divergent changes is most probably what occurs during the growth of the 2 different members of twin pairs , in general discordant for several pathological traits [Roberts et al, 2012]: the question whether this happens also within single organisms seems theoretically legitimate and experimentally approachable [Pearson, 2012]. In addition, the cellular distribution of DNAmodifying-repairing enzymes has been found abundant, even if unevenly distributed in cell lineages and develop- 219 mental stages.…”

Section: From Genomes To Hypergenomesmentioning

confidence: 98%

The Hypergenome in Inheritance and Development

Sgaramella¹

2013

Cytogenet Genome Res

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Both theory and experimentation suggest that during development, the DNA of multicellular organisms, recognized as graced with a lifelong intrinsic stability, is instead target of several modifications (point mutations, larger structural variations, epigenetic marks) and partner of complex interactions with non-DNA moieties (RNAs and proteins). Some of these modifications probably affect a fraction of the genome larger than standard point mutations and are more likely to respond to environmental cues. Thus, the traditional concepts of gene and genome need revision: the structure serving as depository of the overall bioinformation of the cell is more dynamic and less homogeneous than allowed for by the Central Dogma, since in addition to DNA, it includes also RNA and proteins. Each of the individual contributors as well as their stoichiometry undergo modifications. Compared to the traditional unidimensional and static genome, the resulting dynamic aggregate could be more competent to cope with different regulatory requirements: its structural variations may respond to unscheduled macro- and microenvironmental stresses as well as to scheduled genetic programs. A detailed assessment of these variations in time and space should provide a basis for a deeper comprehension of the phenotypic changes punctuating the organism's physio-pathological development, aging and transgenerational transmission. The variations of such information storage-delivery system may interest also the germ cells: the inheritance of parental traits and hence their evolutionary transmission would be affected. For the structure featuring all these properties, we propose the term ‘hypergenome' to underscore the dynamic composition of a complex nucleoprotein responsive to both unpredictable environmental stimuli and internal built-in programs.

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Section: From Genomes To Hypergenomesmentioning

confidence: 98%

The Hypergenome in Inheritance and Development

Sgaramella¹

2013

Cytogenet Genome Res

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“…For example, longitudinal cohort studies have been a cornerstone of observational epidemiology for many years. Long-term follow-up of adult cohorts has identified important risk factors for cardiovascular disease, chronic bronchitis, and cancers, and follow-up of cohorts from birth or childhood has been equally successful at identifying the importance of early exposures (especially the childhood social environment) and developmental characteristics for adult health (for example, [6-10]). Longitudinal studies, particularly those that start in early life, can contribute to our understanding of how the epigenome changes over time, as a result of varying environmental exposures, and how disease phenotypes evolve.…”

Section: Introductionmentioning

confidence: 99%

The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities

Barrett

Wong

et al. 2012

Genome Biol

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“…The radio of the nRF51822 supports 7 transmission power levels ranging from −20 dBm to 4 dBm. SPW-1 has been extensively used by the participants of research studies, conducted by SPHERE [27] and ALSPAC [22] in free-living conditions. Moreover, it has been used in research on energy harvesting solutions for wearable sensors [11].…”

Section: System Designmentioning

confidence: 99%

“…During the first stage of the study in the early 90s, thousands of pregnant women were monitored. More recently, the study continues; monitoring the grandchildren of the originally monitored subjects [22] and the researchers adopt wearable technologies to replace diaries. SPHERE (a Sensor Platform for Healthcare in a Residential Environment) is an interdisciplinary minimum maintenance requirements.…”

Section: Introductionmentioning

confidence: 99%

Designing Wearable Sensing Platforms for Healthcare in a Residential Environment

Fafoutis¹,

Vafeas²,

Janko

et al. 2017

EAI Endorsed Trans Perv Health Tech

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Wearable technologies are valuable tools that can encourage people to monitor their own well-being and facilitate timely health interventions. In this paper, we present SPW-2; a low-profile versatile wearable sensor that employs two ultra low power accelerometers and an optional gyroscope. Designed for minimum maintenance and a long-term operation outside the laboratory, SPW-2 is able to offer a battery lifetime of multiple months. Measurements on its wireless performance in a real residential environment with thick brick walls, demonstrate that SPW-2 can fully cover a room and -in most cases -the adjacent room, as well.

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Children of the 90s: Coming of age

Cited by 38 publications

References 13 publications

The Hypergenome in Inheritance and Development

The Hypergenome in Inheritance and Development

The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities

Designing Wearable Sensing Platforms for Healthcare in a Residential Environment

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