Children’s Multisystem inflammatory syndrome with myopathy

Azevedo, Zina Maria Almeida de; Camacho, Karla Gonçalves; Caixeta, Daniella Mancino da Luz; Lima‐Setta, Fernanda; Salles, Tania Regina Dias Saad; Góes, Fernanda Veiga de; Nehab, Marcio Fernandes; Figueiredo, Carlos; Leite, Maria de Fátima Monteiro Pereira; Vasconcelos, Zilton Farias Meira de; Melgaço, Juliana Gil; Bom, Ana Paula Dinis Ano; Moore, Daniella Campelo Batalha Cox

doi:10.1590/0037-8682-0865-2020

Cited by 3 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From the full‐text reading, 29 more studies were excluded because they did not fit the eligibility criteria. Thus, 50 studies were selected for review, 8–57 and 30 were included in the meta‐analysis (Figure 1). 8–37 …”

Section: Resultsmentioning

confidence: 99%

Cardiac manifestations in children with the multisystem inflammatory syndrome (MIS‐C) associated with SARS‐CoV‐2 infection: Systematic review and meta‐analysis

Arantes

Conegundes

Miranda

et al. 2023

Reviews in Medical Virology

View full text Add to dashboard Cite

According to the World Health Organisation, as of October 2022, there have been 55,560,329 reported cases of SARS‐COV‐2 in patients under 19 years old. It is estimated that about 0.06% of these patients may develop MIS‐C, representing more than 2 million children worldwide. This systematic review and meta‐analysis examined the pooled prevalence of cardiovascular manifestation and cardiac complications in children hospitalised with MIS‐C. The PROSPERO register number is CRD42022327212. We included case‐report studies, case‐control studies, cohort studies, and cross‐sectional studies, as well as clinical trials or studies describing cardiac manifestations of MIS‐C and its sequelae in a paediatric population. Initially, 285 studies were selected, but there were 154 duplicates, and 81 were excluded because they did not fit the eligibility criteria. Thus, 50 studies were selected for review, and 30 were included in the meta‐analysis. A total sample size of 1445 children was included. The combined prevalence of myocarditis or pericarditis was 34.3% (95% CI: 25.0%–44.2%). The combined prevalence for echocardiogram anomalies was 40.8% (95% CI: 30.5%–51.5%), that of Kawasaki disease presentation was 14.8% (95% CI: 7.5%–23.7%), and that of coronary dilation was 15.2% (95% CI: 11.0%–19.8%). The rate of electrocardiogram anomalies was 5.3% (95% CI: 0.8%–12.3%), and the mortality rate was 0.5% (CI 95%: 0%–1.2%). Furthermore, 186 children still had complications at discharge, with a combined prevalence of such long‐lasting manifestations of 9.3% (95% CI: 5.6%–13.7%). Studies that assess whether these children will have an increased cardiovascular risk with a greater chance of acute myocardial infarction, arrhythmias, or thrombosis will be essential for healthcare planning.

show abstract