Chinese expert consensus on assessment of cognitive impairment in the elderly

Ni, Xiushi; Wu, Fang; Song, Juan; An, Li-Na; Jiang, Qianwen; Bai, Tingting; Wang, Qianqian; Yu, Pulin; Zhang, Cuntai; Wu, Jiarui

doi:10.1002/agm2.12222

Cited by 15 publications

(7 citation statements)

References 49 publications

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“…We relied on expert consensus and clinical guidelines that considered the safe and feasible approach when acupuncture therapy started within 72 hours after injury. [30,31] In this study, the acupuncture points were selected based on traditional Chinese medicine theory, our previous pilot study, and summaries of the medical experts' experiences. For example, the acupuncture points of GV26, PC6, and SP6 were selected on the basis of Shi's Xingnaokaiqiao theory, which has achieved significant effects in the treatment of acute and critical cerebrovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

Early complementary acupuncture improves the clinical prognosis of traumatic brain edema

Guo

Jiang²,

Huang

et al. 2022

Medicine

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Background: Traumatic brain edema occurs commonly brain injury, and most manifests as pericontusional edema of brain contusions. On the basis of evidence-based medicine, apart from recommending craniotomy and mannitol, there are few particularly effective measures to prevent and treat traumatic brain edema. It is uncertain whether an early complementary acupuncture treatment would improve long-term outcomes of patients with traumatic brain edema. The aim of this study is to assess the efficacy and the safety of early complementary acupuncture for patients with traumatic brain edema.Methods: This study is an actively accruing, single-center, single-blinded, 2-arm, randomized controlled trial. Patients with traumatic brain injury, a Glasgow Coma Scale score of 6∼12, and brain edema on computed tomography scan will be divided into 2 groups on the basis of stratified block randomization. All patients will receive conventional treatment, and the study group will undergo additional acupuncture therapy (start within 72 hours after the injury) once a day for 28 days. The primary outcome is the dichotomized Glasgow Outcome Score at 6 months and 12 months after injury, and the secondary outcomes are the Glasgow Coma Scale, the volume of traumatic brain edema, the serum levels of C-reactive protein and interleukin-6, and the Modified Barthel Index.Discussion: This study will provide data regarding the efficacy of early complementary acupuncture for traumatic brain edema. If the study yields positive results, its findings may offer insights into a valuable complementary option of acupuncture for traumatic brain edema that could provide pilot evidence for large, randomized, controlled trials.Trial registration: This trial has been published in the Chinese Clinical Trial Register, http://www.chictr.org.cn/edit.aspx?pid= 141208&htm=4 (Identifier: ChiCTR2100053794, registered on December 3, 2021).Abbreviations: CRFs = case report forms, CRP = C-reactive protein, CT = computed tomography, GCS = Glasgow Coma Scale, GOS = Glasgow Outcome Score, ICP = intracranial pressure, IL-6 = interleukin-6, MBI = Modified Barthel Index, RCT = randomized clinical trial, TBE = traumatic brain edema, TBI = traumatic brain injury.

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Section: Discussionmentioning

confidence: 99%

Early complementary acupuncture improves the clinical prognosis of traumatic brain edema

Guo

Jiang²,

Huang

et al. 2022

Medicine

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“…Hypertension has been identified as a risk factor associated with cognitive impairment. 1,2 Previous studies have demonstrated an inverse correlation between blood pressure and the prevalence of cognitive impairment. 3 Furthermore, strict blood pressure management programs have been proposed to mitigate cardiovascular and cerebrovascular events in the oldest old population.…”

Section: Introductionmentioning

confidence: 99%

Association of blood pressure with cognitive impairment in elderly hypertensive patients in China: A cross-sectional study

Jia,

Qi,

Yin

et al. 2023

Preprint

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Aims: To investigate the prevalence of cognitive impairment among elderly Chinese patients with hypertension and explore the relationship between blood pressure and cognitive impairment. Additionally, the study examined the characteristics of cognitive impairment in hypertensive patients and its impact on blood pressure control. Methods: A cross-sectional study was conducted involving 23,271 subjects. Data collection involved questionnaires, physical examinations, and blood tests. AD8 questionnaire, MMSE questionnaire, and neurologist interview, was used to screen patients for cognitive disabilities. Risk factors and prevalence of cognitive impairment were compared between hypertensive and non-hypertensive groups. The prevalence of cognitive impairment at different blood pressure levels was analyzed within the hypertension group. Differences in MMSE scores across dimensions were compared between hypertensive and non-hypertensive groups. Results: The hypertensive group exhibited additional risk factors for cognitive impairment and a higher prevalence of cognitive impairment. The prevalence of cognitive impairment among hypertensive patients followed a U-shaped curve with increasing blood pressure, with the lowest rate observed among patients with blood pressure in the range of 120-139/80-89 mmHg. Several dimensions of cognitive function were significantly diminished in individuals with hypertension. Patients with cognitive impairment demonstrated lower compliance with hypertension treatment and poorer blood pressure control. Conclusion: Cognitive decline across multiple dimensions is typical among older Chinese patients with hypertension, and cognitive impairment has detrimental effects on blood pressure management. Maintaining blood pressure in the 120-139/80-89 mmHg range appears to be more favorable for preserving cognitive function in hypertensive patients.

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“…This includes cognitive decline, which, in severe cases, can develop into cognitive impairment, and subsequently dementia. Cognitive impairment generally refers to varying degrees of cognitive function decline caused by several factors (including memory, computation, temporal and spatial orientation, structural ability, executive ability, language understanding, expression and application, etc.,) ( Ni et al, 2022 ). It is now established that cognitive impairment is associated with various adverse outcomes such as falls, prolonged hospitalization and readmission ( Buslovich and Kennedy, 2012 ; Callahan et al, 2015 ; Ma et al, 2021b ).…”

Section: Introductionmentioning

confidence: 99%

The association of cognitive function and its changes with all-cause mortality among community-dwelling older adults

Li,

He,

et al. 2024

Front. Aging Neurosci.

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BackgroundThe association of cognitive function, its changes, and all-cause mortality has not reached a consensus, and the independence of the association between changes in cognitive function and mortality remains unclear. The purpose of this study was to evaluate the longitudinal association between baseline cognitive function and cognitive changes over 1 year with subsequent all-cause mortality among the older adults aged 60 and above.MethodsA prospective cohort study utilizing the Community Older Adults Health Survey data. Initiated in 2018, the study annually assessed all individuals aged 60+ in Dalang Town, Dongguan City. Cognitive function was assessed using the Chinese version of the Mini-Mental State Examination (MMSE). A total of 6,042 older adults individuals were included, and multivariate Cox proportional hazard models were used to examine cognitive function’s impact on mortality.ResultsParticipants’ median age was 70 years, with 39% men. Over a median 3.08-year follow-up, 525 died. Mortality risk increased by 6% per MMSE score decrease (adjusted HR = 1.06, 95%CI: 1.05–1.08). Compared to those with normal cognitive function at baseline, participants with mild cognitive impairment and moderate to severe cognitive impairment had significantly higher mortality risks (adjusted HR = 1.40, 95%CI: 1.07–1.82; HR = 2.49, 95%CI: 1.91–3.24, respectively). The risk of death was 5% higher for each one-point per year decrease in cognitive function change rate (HR = 1.05, 95%CI: 1.02–1.08). Compared with participants with stable cognitive function, those with rapid cognitive decline had a 79% increased risk of death (adjusted HR = 1.79, 95% CI: 1.11–2.87), with baseline cognitive function influencing this relationship significantly (P for interaction = 0.002).ConclusionBaseline cognitive impairment and rapid cognitive decline are associated with higher all-cause mortality risks in Chinese older adults. Baseline function influences the mortality impact of cognitive changes.

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Chinese expert consensus on assessment of cognitive impairment in the elderly

Cited by 15 publications

References 49 publications

Early complementary acupuncture improves the clinical prognosis of traumatic brain edema

Early complementary acupuncture improves the clinical prognosis of traumatic brain edema

Association of blood pressure with cognitive impairment in elderly hypertensive patients in China: A cross-sectional study

The association of cognitive function and its changes with all-cause mortality among community-dwelling older adults

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