Chinese expert consensus on the clinical applications of aminolevulinic acid-based photodynamic therapy in female lower genital tract diseases (2022)

Qiu, Lihua; Li, Jingran; Chen, Fei; Wang, Yifeng; Wang, Yue; Wang, Xinyu; Lv, Qiubo; Li, Changzhong; Li, Mingzhu; Yang, Qixiang; Wu, Dan; Zhang, Youzhong; Zhang, Yuquan; Zhang, Mengzhen; Qie, Mingrong; Zhou, Huaijun; Zhou, Jianli; Zhao, Weidong; Xia, Bairong; Liang, Xuefang; Cai, Yefeng; Teng, Yincheng; Huang, Zheng; Sui, Long; Wei, Lihui; Di, Wen

doi:10.1016/j.pdpdt.2022.102993

Cited by 30 publications

(20 citation statements)

References 17 publications

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“…5‐ALA can be applied directly to the lesion inside the endocervical canal, and followed by phototherapy with inserted luminescent laser fiber. As the results, 5‐ALA PDT can be an effective treatment for endocervical canal LSIL 8,9 …”

Section: Introductionmentioning

confidence: 80%

“…As the results, 5-ALA PDT can be an effective treatment for endocervical canal LSIL. 8,9 Within the framework of our study, our objective is to assess the clinical efficacy and the practical utility of 5-ALA PDT in managing endocervical canal LSIL in the presence of hrHPV infection, with the goal of enhancing the early intervention for endocervical precancerous lesions.…”

Section: Introductionmentioning

confidence: 99%

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Rational of topical photodynamic therapy (PDT) with 5‐aminolevulinic acid (5‐ALA) for treatment of endocervical canal low‐grade squamous intraepithelial lesion with high‐risk human papillomavirus infection

Yuan,

He,

Zhu

et al. 2023

Lasers Surg Med

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BackgroundThe detection and continuous monitoring of low‐grade squamous intraepithelial lesions (LSIL) within the endocervical canal pose considerable challenges, and the effectiveness of ablation treatment is also constrained. In this context, the potential efficacy of 5‐aminolevulinic acid photodynamic therapy (5‐ALA PDT) in targeting these concealed lesions merits exploration. The present study undertakes a comprehensive analysis of the clinical effectiveness and safety aspects associated with the utilization of 5‐ALA PDT.MethodsA retrospective analysis was conducted on a cohort of 13 patients who were diagnosed with LSIL within the endocervical canal, concomitant with high‐risk human papillomavirus (hrHPV) infection. These patients were subjected to treatment with 5‐ALA PDT and subsequently monitored over a period of 3−6 months following the intervention.ResultsThe study cohort comprised 13 patients, among whom 4 presented with isolated lesions within the endocervical canal, 5 exhibited LSIL involving both the endocervical canal and the cervix vaginal portion, 3 displayed LSIL within the endocervical canal in conjunction with vaginal involvement, and 1 patient demonstrated lesions across all three of these anatomical sites. All identified lesions underwent therapeutic intervention via 5‐ALA PDT. Before treatment initiation, 9 patients returned positive results in the liquid‐based cytologic test (LBC), 4 displayed concurrent multiple hrHPV infections, and 5 manifested infections specifically with HPV 16/18. Subsequent to the application of 5‐ALA PDT, regression was observed in the LBC results of all patients, with only 3 individuals retaining a singular type of hrHPV infection. Adverse reactions following treatment encompassed mild aberrant vaginal secretions and mild to moderately pronounced distending abdominal discomfort, all of which were remitted within a span of 7 days.ConclusionsWithin the context of LSIL within the endocervical canal in association with hrHPV infection, the findings affirm the efficacy and safety of 5‐ALA PDT as a viable therapeutic modality.

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Section: Introductionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Rational of topical photodynamic therapy (PDT) with 5‐aminolevulinic acid (5‐ALA) for treatment of endocervical canal low‐grade squamous intraepithelial lesion with high‐risk human papillomavirus infection

Yuan,

He,

Zhu

et al. 2023

Lasers Surg Med

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“…15 Utiliza-se três componentes na terapia fotodinâmica com a finalidade de destruir as células infectadas, que são uma fonte de luz (lâmpada, laser, diodo emissor de luz -LED), fotossensibilizador (OS) e oxigênio, juntos realizam reações para a destruição das células anormais. 3,11,20,22 A finalidade da TFD é a destruição seletiva de um tecido, que é dividida em duas partes, uma que usa droga sensibilizante sistêmica ou tópica e outra por irradiação com luz visível. Os fotossensibilizantes podem ser exógenos ou endógenos, possuem sua ativação através da luz e transferem a energia para o oxigênio molecular, a partir disso estimulando a morte celular.…”

Section: Terapia Fotodinâmicaunclassified

“…Nos últimos anos seu uso foi estendido para outras doenças do trato genital feminino como escamosas lesões intraepiteliais, líquen escleroso vulvar e condiloma acuminatum. 16,22 Efeitos adversos como dor, queimação, prurido na área tratada, sensação de ardência são comuns durante a exposição à terapia e melhoram depois de algumas horas. Desconforto local, corrimento vaginal também são encontrados.…”

Section: 1619unclassified

“…3 , 1 1 , 1 6 , 1 9 , 2 0 Esse método possui as vantagens de diminuir os traumas, causa menores reações adversas, repetibilidade, seletividade, uma recuperação funcional rápida, além de não ser um fator predisponente para infertilidade. 22 Os efeitos adversos encontrados são dor, queimação, prurido na área tratada, sensação de ardência, desconforto local, corrimento vaginal, náuseas, vômitos, eritema e Brazilian Journal of Health Review, Curitiba, v. 6, n. 4, p. 14087-14105, jul./aug., 2023 edema. 1 0 , 1 6 , 1 9 Essa terapia se mostra como uma técnica muito atrativa para tratar lesões malignas no estágio inicial.…”

Section: Introductionunclassified

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Terapia fotodinâmica no tratamento das Neoplasias Intraepiteliais Cervicais: uma longa revisão bibliográfica

Lombardi,

Lustri,

Lombardi

et al. 2023

Braz. J. Hea. Rev.

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Introdução: O papilomavírus humano (HPV), é um vírus sexualmente transmissível cuja infecção predispõe a neoplasia intraepitelial cervical (NIC) a qual pode evoluir para um câncer do colo do útero. Os principais tratamentos utilizados atualmente para HPV e NIC, apesar de serem eficazes, são invasivos, ocorrendo efeitos adversos. A terapia fotodinâmica (TFD) é uma novidade terapêutica alternativa para essas terapias convencionais e trata o paciente de forma minimamente invasiva erradicando células-alvo, preservando regiões saudáveis e evitando toxicidade sistêmica. Objetivo: Esta revisão teve como objetivo ampliar e atualizar as informações sobre a TFD, a respeito do seu mecanismo de ação, dificuldades, os benefícios para a qualidade de vida das pacientes e suas vantagens em relação a outros tratamentos utilizados atualmente. Metodologia: Foi feito um levantamento eletrônico de artigos nacionais e internacionais, entre os anos de 2002 a 2022, disponibilizados nas bases de dados Scielo, Google Acadêmico e Pubmed. Revisão: As neoplasias intraepiteliais cervicais em sua grande maioria têm como precursor o HPV, as quais podem evoluir para um carcinoma cervical. Existem diversas formas de tratamento tradicionais que possuem menores benefícios em relação a um método alternativo como a terapia fotodinâmica. Conclusão: A Terapia Fotodinâmica vem se mostrando segura e eficaz para eliminar seletivamente células tumorais, evitando efeitos sistêmicos de toxicidade e preservando o tecido saudável. Sendo assim, a TFD apresenta vantagens claras em relação a outras modalidades de tratamento: não apresenta efeitos colaterais a longo prazo, menos invasiva que métodos cirúrgicos e pode ser direcionada a um tecido alvo com muita precisão.

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Clinical Effect Analysis and Prognostic Factors of Photodynamic Therapy for Cervical Precancerous Lesions

Zhu,

Guo,

et al. 2024

Journal of Biophotonics

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ObjectiveTo evaluate the therapeutic effect of photodynamic therapy (PDT) on cervical precancerous lesions and prognostic factors.Methods173 patients diagnosed with cervical precancerous lesions and treated with PDT were included. Univariate analysis was performed on human papillomavirus (HPV) infection, patient age, number of treatments and number of medications before and after treatment, to evaluate the efficacy, adverse reactions and patient satisfaction.Results112 patients (64.5%) showed HPV clearance afrer PDT. Age ≥ 40 years was positively correlated with poor prognosis and number of treatments ≥ 6 was negatively correlated with poor prognosis. The satisfaction rate reached 94.79%, with 6 patients experiencing tolerable pain and no treatment discontinuations due to adverse reactions.ConclusionPDT is effective and safe for treating cervical precancerous lesions, with patient age and treatment frequency impacting outcomes. High patient satisfaction and tolerable adverse reactions support the application of PDT in clinical practice.

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Chinese expert consensus on the clinical applications of aminolevulinic acid-based photodynamic therapy in female lower genital tract diseases (2022)

Cited by 30 publications

References 17 publications

Rational of topical photodynamic therapy (PDT) with 5‐aminolevulinic acid (5‐ALA) for treatment of endocervical canal low‐grade squamous intraepithelial lesion with high‐risk human papillomavirus infection

Rational of topical photodynamic therapy (PDT) with 5‐aminolevulinic acid (5‐ALA) for treatment of endocervical canal low‐grade squamous intraepithelial lesion with high‐risk human papillomavirus infection

Terapia fotodinâmica no tratamento das Neoplasias Intraepiteliais Cervicais: uma longa revisão bibliográfica

Clinical Effect Analysis and Prognostic Factors of Photodynamic Therapy for Cervical Precancerous Lesions

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