Chinese herbal compounds against SARS-CoV-2: Puerarin and quercetin impair the binding of viral S-protein to ACE2 receptor

Pan, Bo; Fang, Shumin; Zhang, Ju; Pan, Ya; Liu, Han; Wang, Yun; Li, Min; Liu, Liren

doi:10.1016/j.csbj.2020.11.010

Cited by 95 publications

(75 citation statements)

References 31 publications

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“…The above observations and inference suggest that the diterpenoid forskolin may be a good inhibitor of RBD-ACE2 binding and may prevent the entrance of SARS-CoV-2 into human cells for infection. Some related studies in literature which conceptualize on the inhibition of protein-protein binding reported compounds which binds to the region of RBD residues and thus, further impede the binding of RBD to ACE-2 26 where as another study involves the effect of two Chinese herbal compounds puerarin and quercetine which impair the binding of viral S protein to ACE2 receptor when docked with Human receptor for receptor binding domain of viral protein 27 . Only one cell line-based study involving colforsin (forskolin) where colforsin and 5 other compounds were tested and found to be broad spectrum inhibitors for spike-mediated entry of SARS-CoV-2 28 .…”

Section: Resultsmentioning

confidence: 99%

In Silico Analysis of Forskolin as a Potential Inhibitor of SARS-CoV-2

Kumari¹,

Kumar²,

Kumar³

et al. 2021

J Pure Appl Microbiol

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Coronavirus disease 2019 (COVID–19) has spread rapidly as global pandemic affecting 187 countries/ regions and emerged as worldwide health crisis. Potential antiviral drugs used for the SARS -CoV-2 in clinical treatments have side effects. However, emergency vaccines are in use but despite that increase in the coronavirus cases are alarming. Thus, it is utmost need of safer antiviral agent to treat or inhibit the viral infection. Forskolin has been reported as a possible antiviral-agent. This molecule was docked with ACE2 receptor of human which is the target for the binding of S1 unit of viral S protein of SARS-CoV- 2. In silico docking was carried out on SwissDock, PatchDock and FireDock servers. The docked ACE2 structure was further docked with the RBD of the spike protein. Forskolin is able to H-bond with the hACE2 and ACE2-forskolin fails to interact with the receptor-binding domain (RBD) of the Spike protein of SARS-CoV-2. Instead, viral RBD is repulsed by the diterpene molecule through obliteration and reciprocated binding. We report first that forskolin plays a crucial role in the inhibition of protein-protein interaction of RBD and ACE2 when docked with either of the protein.

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Section: Resultsmentioning

confidence: 99%

In Silico Analysis of Forskolin as a Potential Inhibitor of SARS-CoV-2

Kumari¹,

Kumar²,

Kumar³

et al. 2021

J Pure Appl Microbiol

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“…Boyu Pan et, al. reported that quercetin not only has a receptor blocking effect, but also has a virus-neutralizing effect on SARS-CoV-2, suggesting a promising candidate against COVID-19 [ 113 ]. Additionally, the top ten targets such as COX-2, CASP3, IL-6, MAPK1, EGFR, IL-2, TNF and CCL-2 are closely linked to the top ten signaling pathway of IL-17, HIF-1, NF-κB, Ras, TNF, MAPK, PI3K-Akt, Toll-like receptor and Th17 cell differentiation [ 4 ].…”

Section: Role Of Tcm In Covid-19 Treatmentmentioning

confidence: 99%

Research progress of traditional Chinese medicine against COVID-19

Ren

Liang

et al. 2021

Biomedicine & Pharmacotherapy

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“…Baicalein and quercetin are the top two compounds of HD, with high affinity for ACE2 ( Tao et al, 2020 ). Another study has suggested that quercetin not only impairs the binding of viral S-protein to ACE2 receptor, but also has virus neutralizing effect of quercetin on SARS-CoV-2 ( Pan et al, 2020 ). As mentioned, ACE2 is a key component of the bradykinin storm in addition to serving as a receptor of SAR-CoV-2.…”

Section: For Treatment Of Severe Stage Of Covid-19—huashibaidu Decoctmentioning

confidence: 99%

Prospective: Evolution of Chinese Medicine to Treat COVID-19 Patients in China

Sun

Hou

et al. 2021

Front. Pharmacol.

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During the outbreak of the novel coronavirus disease (COVID-19), the Chinese government took a series of public health measures to tackle the outbreak and recommended six traditional Chinese medicine (TCM) evolved formulas, collectively referred to as “3-drugs-3-formulas”, for the treatment. In this prospective article, we will discuss how these six formulas evolved from TCM and what their underlying mechanisms of actions may be by evaluating the historical usage of the component formulas, the potential targeted pathways for the individual herbs used by STAR (signal transduction activity response) database from our laboratory, and the pathogenesis of COVID-19. Five of the six recommended formulas are administered orally, while the sixth is taken as an injection. Five classic categories of herbs in the six formulas including “Qing-Re”, “Qu-Shi”, “Huo-Xue”, “Bu-Yi” and “Xing-Qi” herbs are used based on different stages of disease. All five oral formulas build upon the core formula Maxingshigan Decoction (MD) which has anti-inflammatory and perhaps antiviral actions. While MD can have some desired effects, it may not be sufficient to treat COVID-19 on its own; consequently, complementary classic formulas and/or herbs have been added to potentiate each recommended formula’s anti-inflammatory, and perhaps anti-renin-angiotensin system (RAS)-mediated bradykinin storm (RBS) and antiviral effects to address the unique medical needs for different stages of COVID-19. The key actions of these formulas are likely to control systemic inflammation and/or RBS. The usage of Chinese medicine in the six formulas is consistent with the pathogenesis of COVID-19. Thus, an integrative systems biology approach—combining botanical treatments of conventional antiviral, anti-inflammatory or anti-RBS drugs to treat COVID-19 and its complications – should be explored.

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Chinese herbal compounds against SARS-CoV-2: Puerarin and quercetin impair the binding of viral S-protein to ACE2 receptor

Cited by 95 publications

References 31 publications

In Silico Analysis of Forskolin as a Potential Inhibitor of SARS-CoV-2

In Silico Analysis of Forskolin as a Potential Inhibitor of SARS-CoV-2

Research progress of traditional Chinese medicine against COVID-19

Prospective: Evolution of Chinese Medicine to Treat COVID-19 Patients in China

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