Chinese Herbal Medicine for Improving Quality of Life Among Nonsmall Cell Lung Cancer Patients

Wu, Xinyin; Chung, Vincent C.H.; Lü, Ping; Poon, Simon K.; Hui, Edwin P.; Lau, Alexander; Balneaves, Lynda G.; Wong, Samuel Yeung Shan; Wu, Justin C. Y.

doi:10.1097/md.0000000000002410

Cited by 39 publications

(38 citation statements)

References 37 publications

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“…Even after clinical treatment, five-year survival rate is still low [ 23 – 25 ]. Current clinical evidence has indicated that in comparison to patients with non-small cell lung cancer (NSCLC) receiving chemotherapy, the patients using traditional Chinese medicine (TCM) had longer lifespan and higher quality of life [ 26 ]. Thus, the component formula with definite and effective components provided new opportunity to treatment lung cancer.…”

Section: Discussionmentioning

confidence: 99%

The component formula of Salvia miltiorrhiza and Panax ginseng induces apoptosis and inhibits cell invasion and migration through targeting PTEN in lung cancer cells

Yan

Yang

et al. 2017

Oncotarget

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Lung cancer still remains the leading cause of cancer-related death worldwide. It is an urgent need for development of novel therapeutic agents to improve current treatment of this disease. Here we investigate whether the effective component formula of traditional Chinese Medicine could serve as new potential therapeutic drugs to treat lung cancer. We optimize the most effective component formula of Salvia miltiorrhiza and Panax Ginseng (FMG), which is composed of Salvianolic acid A, 20(S)-Ginsenoside and Ginseng polysaccharide. We discovered that FMG selectively inhibited lung cancer cell proliferation and induced apoptosis but had no any cytotoxic effects on normal lung epithelial BEAS-2B cells. Moreover, FMG inhibited lung cancer cell migration and invasion. Mechanistically, we found that FMG significantly promoted p-PTEN expression and subsequently inhibited PI3K/AKT signaling pathway. The phosphatase activity of PTEN protein was increased after FMG bound to PTEN protein, indicating that PTEN is one of the FMG targeted proteins. In addition, FMG regulated expression of some marker proteins relevant to cell apoptosis, migration and invasion. Collectively, these results provide mechanistic insight into the anti-NSCLC of FMG by enhancing the phosphatase activity of PTEN, and suggest that FMG could be as a potential option for lung cancer treatment.

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Section: Discussionmentioning

confidence: 99%

The component formula of Salvia miltiorrhiza and Panax ginseng induces apoptosis and inhibits cell invasion and migration through targeting PTEN in lung cancer cells

Yan

Yang

et al. 2017

Oncotarget

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“…These adverse effects include cardiotoxicity, nephrotoxicity, hepatotoxicity, and peripheral neuropathy (Duwe et al, ; Ma, Kavelaars, Dougherty, & Heijnen, ; Santoni et al, ; Sharbaf et al, ). Sometimes, the adverse effects severely affect the daily quality of life for patients (X. Wu et al, ). Many of the adverse effect of chemotherapeutic drugs are caused by the drug itself and its metabolites, usually by inducing ROS formation (Varricchi et al, ).…”

Section: Herbal Compounds With the Potential To Synergize With Antitumentioning

confidence: 99%

Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence

Lin

Hsu

Tsai

et al. 2019

British J Pharmacology

289

175

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Traditional chemotherapy is being considered due to hindrances caused by systemic toxicity. Currently, the administration of multiple chemotherapeutic drugs with different biochemical/molecular targets, known as combination chemotherapy, has attained numerous benefits like efficacy enhancement and amelioration of adverse effects that has been broadly applied to various cancer types. Additionally, seeking natural‐based alternatives with less toxicity has become more important. Experimental evidence suggests that herbal extracts such as Solanum nigrum and Claviceps purpurea and isolated herbal compounds (e.g., curcumin, resveratrol, and matairesinol) combined with antitumoral drugs have the potential to attenuate resistance against cancer therapy and to exert chemoprotective actions. Plant products are not free of risks: Herb adverse effects, including herb–drug interactions, should be carefully considered. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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“…In addition, previous studies confirmed that CKI had the effect of heat-clearing, dampness-expelling, blood cooling, detoxification, and sanjie analgesic effect [ 20 ]. It is extensively used for the treatment of pain and bleeding with malignant tumor such as liver cancer [ 21 ], lung cancer [ 22 ], and gastrointestinal cancer [ 18 ]. The suggested mechanisms of action are increasing protein expression, inhibiting vascular endothelial growth factor expression in neoplastic tissues, killing cell activity, inducing tumor cells to normal cell differentiation, and promoting cell apoptosis and so on [ 23 – 26 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Compound Kushen Injection on Patients with Advanced Colon Cancer: A Meta‐Analysis of Randomized Controlled Trials

Zhou

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Objective The efficacy and safety of Compound Kushen Injection (CKI) on advanced colon cancer remain controversial. We undertook a systematic meta-analysis of randomized controlled clinical studies on this issue. Methods A comprehensive literature search was conducted by searching the following electronic databases: PubMed, Cochrane, Chinese Biological Medical disc, Chinese National Knowledge Infrastructure, and Wan-Fang Database in China by the end of January 31, 2017, without language restriction. Meta-analysis was performed by using the random effects model to estimate the summary odd ratio (OR) with 95% confidence interval (CI) according to the study design. Stata 12.0 software was used for data analysis. The heterogeneity, sensitivity, and publication bias were assessed, respectively. Results A total of 14 trials met the inclusion criteria in present meta-analysis. The results suggested that CKI combined with chemotherapeutic drugs was favorable for the treatment of advanced colon cancer and could improve the patients' life quality. Funnel plot analysis and Egger's test suggested that there was not significant publication bias, and the sensitivity analysis indicated stable results. Conclusion The current evidence suggested that CKI is favorable to improve the efficacy of chemotherapeutic drugs in patients with advanced colon cancer.

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Chinese Herbal Medicine for Improving Quality of Life Among Nonsmall Cell Lung Cancer Patients

Abstract: Supplemental Digital Content is available in the text

Cited by 39 publications

References 37 publications

The component formula of Salvia miltiorrhiza and Panax ginseng induces apoptosis and inhibits cell invasion and migration through targeting PTEN in lung cancer cells

The component formula of Salvia miltiorrhiza and Panax ginseng induces apoptosis and inhibits cell invasion and migration through targeting PTEN in lung cancer cells

Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence

Efficacy and Safety of Compound Kushen Injection on Patients with Advanced Colon Cancer: A Meta‐Analysis of Randomized Controlled Trials

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