Chinese herbal medicine Qinggongshoutao for the treatment of amnestic mild cognitive impairment: A 52‐week randomized controlled trial

Abstract

Introduction This randomized, double-blind trial aimed to test effect of a Chinese herbal medicine, Qinggongshoutao (QGST) pill, on the cognition and progression of amnestic mild cognitive impairment (aMCI). Methods Patients with aMCI were randomly assigned to receive QGST, Ginkgo biloba extract, or placebo for 52 weeks. The primary outcome measures were progression to possible or probable Alzheimer's disease (AD) and change in Alzheimer's Disease Assessment Scale–cognitive subscale scores; secondary outcome measures included assessments for cognition and function. Results Total 350 patients were enrolled, possible or probable AD developed in 10. There were significant differences in the probability of progression to AD in the QGST group (1.15%) compared with placebo group (10%). There was significant difference in Alzheimer's Disease Assessment Scale–cognitive subscale scores in favor of QGST over the placebo group. Secondary outcome measure (Mini-Mental State Examination) also showed benefit in QGST at end point. Discussion In patients with aMCI, QGST showed lower AD progression rate than placebo at 8.85%, and may have benefit on global cognition.

An Updated Review of Randomized Clinical Trials Testing the Improvement of Cognitive Function of Ginkgo biloba Extract in Healthy People and Alzheimer’s Patients

“…Alzheimer's disease (AD) is one of the age-related cognitive decline. It is a main challenge of mental health research (Tian et al, 2019), and is clinically characterized by cognitive dysfunction, neuronal injury, and synapse loss (Vanderstichele et al, 2019). Currently, there are approximately 50 million AD patients in the world (Bello-Medina et al, 2019).…”

Herbs’ Disease-matched Pharmacological Mechanisms of HuanglianJiedu Decoction in Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease

“…So, following our research is herbs' disease-matched combination of HLJDD in treating BPSD. The combination of herbs into a prescription to enhance their overall therapeutic effects or eliminate the adverse effects (Tian et al, 2019), is referred to as TCM combination. Although prescriptions have conventional combinations, it is essential to consider novel combinations for different diseases.…”

Novel Compatibility of Huanglianjiedu Decoction in Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease1

“…Kidney essence de ciency is a primary syndrome differentiation of AD in TCM theory. "Liver re" is the largest contributor to BPSD due to the imbalance between yin and yang of liver function [33,34] . PCC acts on the lower energizer can purge the liver re.…”