Chip calorimeter for thermal characterization of bio-chemical solutions

Adrega, T.; Herwaarden, A.W. van

doi:10.1016/j.sna.2011.03.027

Cited by 14 publications

(9 citation statements)

References 16 publications

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“…42 However, this method requires calibration of the device with various samples of known thermal diffusivity to fit the two unknown parameters. In this paper, the non-steady-state (transient) method is used to measure the thermal diffusivity of liquid samples.…”

Section: A Thermal Diffusivity Measurementmentioning

confidence: 99%

A novel on-chip three-dimensional micromachined calorimeter with fully enclosed and suspended thin-film chamber for thermal characterization of liquid samples

et al. 2014

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A microfabricated calorimeter (l-calorimeter) with an enclosed reaction chamber is presented. The 3D micromachined reaction chamber is capable of analyzing liquid samples with volume of 200 nl. The thin film low-stress silicon nitride membrane is used to reduce thermal mass of the calorimeter and increase the sensitivity of system. The l-calorimeter has been designed to perform DC and AC calorimetry, thermal wave analysis, and differential scanning calorimetry. The l-calorimeter fabricated with an integrated heater and a temperature sensor on opposite sides of the reaction chamber allows to perform thermal diffusivity and specific heat measurements on liquid samples with same device. Measurement results for diffusivity and heat capacitance using time delay method and thermal wave analysis are presented. V C 2014 AIP Publishing LLC. [http://dx

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Section: A Thermal Diffusivity Measurementmentioning

confidence: 99%

A novel on-chip three-dimensional micromachined calorimeter with fully enclosed and suspended thin-film chamber for thermal characterization of liquid samples

et al. 2014

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“…Usually, microcalorimeters include a reaction chamber, a temperature sensor to measure the heat released or absorbed by the chemical reaction of the samples in the reaction chamber [4] and also include heaters for device calibration; moreover, differential microcalorimeters use an additional chamber as a reference chamber [5]. Some calorimeters use thermistors [6,7] or thermopiles [5,[8][9] as thermal sensors, however, thermopiles have higher sensitivity than thermistors due to the absence of an electrical current [4]. Since thermopiles convert thermal energy into electrical, they have zero offset and the flicker noise could not affect static detection [10].…”

Section: Introductionmentioning

confidence: 99%

Thermoelectrical characterization and comparative analysis of three finite element models of a MEMS thermal sensor

Franco

Treviño

Figueras

et al. 2018

Superficies y Vacio

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This document presents the finite element modeling using ANSYS to obtain the thermal resistance of a MEMS thermal sensor. Additionally, the document describes a thermoelectrical characterization to find the sensor performance parameters. For modeling purposes, we divided the thermal sensor into four different thickness zones. We analyzed three different models, the first includes all materials layers, the second involves an equivalent thermal conductivity and an equivalent thickness for each zone, and the proposed model besides using an equivalent thermal conductivity by zone also considers the same thickness for all zones to reduce simulation time and to optimize thermal sensor design parameters. The first model evaluates three different boundary conditions, while the second and third models consider two different thermopile wide strips. The thermal resistance of the proposed model has a relative error of 11% in relation to the experimental value. The model, considering all layers and heat power applied to the surface as boundary conditions, has the lowest error (9%), while models considering the thermopile strips width have shown a higher error, 67%. As a result, the proposed model for heat transfer analysis simplifies complex geometries and reduces simulation time.

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“…The microfabricated chip calorimeter uses a thermocouple array (thermopile) to detect the heat involved in a chemical or biological process, such as the development of bacterial biofilms on surfaces [ 3 , 4 ], the response of biofilms to various antibiotics and predation agents [ 5 – 7 ], thermal transition and heat of mixing of substances [ 8 ], growth of single zebra fish embryos [ 9 ], DNA hybridization [ 10 ], heat transfer from the activity of enzymes [ 11 ], heat flow from single or a few fat cells [ 12 ]. A commercially available chip calorimeter were also designed and marketed [ 3 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of a Multichannel 3D Thermopile for Chip Calorimeter Applications

Huynh

Zhang

Cohen

2015

Sensors

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Thermal sensors based on thermopiles are some of the most robust and popular temperature sensing technologies across industries and research disciplines. A chip calorimeter with a 3D thermopile layout with a large sensing area and multichannel capacity has been developed, which is highly desired for many applications requiring large reaction chambers or high throughputs, such as biofilm research, drug screening, etc. The performance of the device, including temperature sensitivity and heat power sensitivity, was evaluated. The capability to split the chip calorimeter to multiple channels was also demonstrated, which makes the chip calorimeter very flexible and powerful in many applications.

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Chip calorimeter for thermal characterization of bio-chemical solutions

Cited by 14 publications

References 16 publications

A novel on-chip three-dimensional micromachined calorimeter with fully enclosed and suspended thin-film chamber for thermal characterization of liquid samples

A novel on-chip three-dimensional micromachined calorimeter with fully enclosed and suspended thin-film chamber for thermal characterization of liquid samples

Thermoelectrical characterization and comparative analysis of three finite element models of a MEMS thermal sensor

Fabrication and Characterization of a Multichannel 3D Thermopile for Chip Calorimeter Applications

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