Chiral and achiral platinum(II) complexes for potential use as chemotherapeutic agents: crystal and molecular structures of cis-[Pt(L1)2] and [Pt(L1)Cl(MPSO)] [HL1 = N,N-diethyl-N ′-benzoylthiourea]

Abstract

Chiral and achiral platinum(II) complexes for potential use as chemotherapeutic agents: crystal and molecular structures of cis-[Pt(L 1 ) 2 ] and [Pt(L 1 )Cl(MPSO)] [HL 1 ‫؍‬ N,N-diethyl-NЈbenzoylthiourea]

On the cytotoxic activity of Pd(II) complexes of N,N-disubstituted-N′-acyl thioureas

“…Some of them are employed as fungicidal, antiviral, antimicrobial [10], parasiticidal [11], antitumoral [12] and pesticidal agent [13][14][15]. Indeed cytotoxicity studies using HeLa cancer cell lines have demonstrated that some of these platinum acyl thioureas show cytotoxic behavior, with the antiproliferative effects being dependent on the nature/type of the substituent in the acyl thiourea ligand [16][17][18]. Having this in mind our research group has been interested in developing new thiosemicarbazones or similar ligands, including polydentate ones such as acyl thioureas, containing N, S and O atoms with the capacity to form transition metal complexes.…”

Chiral and Achiral Macrocyclic Copper(II) Complexes: Synthesis, Characterization, and Comparative Binding Studies with Calf-Thymus DNA

“…Single enantiomeric drugs used in recent years constitutes > 30% of total therapeutic drugs [5] [6]. The structure -function relationship in nature is so powerful that, when a functional disorder is manifested in the form of a disease, it can be handled in many cases only by using a molecule of specific chiral structure [7]. Thus, the introduction of chirality enhances selective binding of the complexes to molecular targets.…”

Structure/Activity of PtII/N,N-Disubstituted-N’-acylthiourea Complexes: Anti-Tumor and Anti-Mycobacterium tuberculosis Activities

“…In the complexes (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) there are two coordinated triphenylphosphine ligands, in cis position, according to the 31 P{ 1 H} NMR data, and their molar conductivities show that the complexes are cationic species. 39 The NMR ( 1 H and 13 C{ 1 H}) spectroscopy was used to speculate about the molecular structures of the complexes, and a comparative analysis on the basis of the spectroscopic data corresponding to both, free and coordinated ligands with the metallic ion, was performed.…”

“…The N,N-disubstituted-N'-acylthiourea ligands L (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) used in this work were synthesized by the procedure previously reported, and the identity of the products was confirmed by comparing their 1 H and 13 C{ 1 H} NMR data with those reported in the literature. 21 The groups R1 and R2 of the ligands are shown in Figure 1.…”

“…[2][3][4][5][6][7][8][9] Thus, in an attempt to overcome the drawbacks of cisplatin and derivatives (severe toxicity, drug resistance and poor oral bioavailability), the development of platinum-based drugs have progressed to the newest generation of drugs, such as satraplatin, picoplatin and the multinuclear platinum complex BBR3464 (triplatin). In this context, platinum(II) complexes of the type [Pt(L)Cl(DMSO)] (L = acylthiourea ligand, R1-C(O)NHC(S)NR2; R' = aryl, NR2 = amine; DMSO = dimethylsulfoxide) were prepared by Sacht et al [10][11][12] for their biological and chemical evaluation. The acylthiourea group, after deprotonation of the amide moiety (NHCO), can act as a bidentate chelating ligand, coordinating to platinum through the oxygen and sulfur donor atoms.…”