Chiral covalent triazine framework CC-DMP CCTF@SiO<sub>2</sub> core–shell microspheres used for HPLC enantioseparation

Zhu, Yu-Lan; Guo, Ping; Yang, Yu-Ping; Ran, Xiao-Yan; Liu, Cheng; Wang, Bang-Jin; Zhang, Junhui; Xie, Sheng‐Ming; Yuan, Liming

doi:10.1039/d2nj06097c

Cited by 8 publications

(6 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to the use of chiral PCMs (MOFs, COFs, MOCs, and POCs) as chromatographic CSPs. Other chiral porous materials include homochiral metallacycle [129], CPM [130,131], chiral porous organic polymers [132], chiral covalent triazine frameworks [133,134], chiral multi-shelled mesoporous carbon nanospheres [135], chiral hydrogen-bonded organic frameworks [136] are also being developed as CSPs for chromatographic chiral separations and showed good separation performance for many racemates. With the continuous research of new chiral porous materials, we believe that it will have good potential for practical application as an emerging CSP.…”

Section: Chiral Mocs-based Cspsmentioning

confidence: 99%

Recent progress for chiral stationary phases based on chiral porous materials in high‐performance liquid chromatography and gas chromatography separation

Wang,

Luo

et al. 2024

J of Separation Science

View full text Add to dashboard Cite

Chirality is a fundamental property of nature. Separation and analysis of racemates are of great importance in the fields of medicine and the production of chiral biopharmaceutical intermediates. Chiral chromatography has the characteristics of a wide separation range, fast separation speed, and high efficiency. The development and preparation of novel chiral stationary phases with good chiral recognition and separation capacity is the core and key of chiral chromatographic separation and analysis. In this work, the representative research progress of novel chiral porous crystal materials including chiral covalent organic frameworks, chiral porous organic cages, chiral metal‐organic frameworks, and chiral metal‐organic cages used as chiral stationary phases of capillary gas chromatography and high‐performance liquid chromatography over the last 4 years is reviewed in detail. The chiral recognition and separation properties of the representative studies in this review are also introduced and discussed.

show abstract

Section: Chiral Mocs-based Cspsmentioning

confidence: 99%

Recent progress for chiral stationary phases based on chiral porous materials in high‐performance liquid chromatography and gas chromatography separation

Wang,

Luo

et al. 2024

J of Separation Science

View full text Add to dashboard Cite

show abstract

“…Zhu et al synthesized chiral covalent triazine framework CCTFs (Figure 7d) and fabricated a composite microspherical CC-DMPCCTF@SiO 2 with a uniform core−shell structure using an in situ growth method. 67 They used this composite material as the stationary phase in HPLC for the separation of chiral compounds such as alcohols, amines, ketones, etc. Compared with traditional commercial chirality and previously synthesized CCOF@SiO 2 , this new composite was found to be complementary and showed superior reproducibility and stability.…”

Section: Chromatographic Separation By Hplcmentioning

confidence: 99%

Section: Racemate Resolutionmentioning

confidence: 99%

Chiral Covalent Organic Frameworks as Promising Materials for Racemate Resolution

Wang,

Zhang,

et al. 2024

ACS Appl. Polym. Mater.

View full text Add to dashboard Cite

Enantiomeric excess and purity play pivotal roles across various fields, foremost among them the pharmaceutical industry. Chiral resolution is a crucial technique, enabling the analysis of enantiomeric excess and the procurement of purified enantiomers. Despite their widespread utilization, chiral materials still encounter numerous challenges. Recently, covalent organic frameworks (COFs), as emerging porous organic materials, stand out as promising platforms for various applications due to their high porosity, ordered crystallinity, and exceptional thermal and chemical stability. In particular, the chiral COFs (CCOFs) have emerged as promising candidates for racemate resolution. However, systematic reviews on chiral resolution utilizing CCOFs are scant, likely due to their nascent application. This review delves into the synthesis of CCOFs, summarizing three primary methods: direct synthesis, postsynthesis, and chiral induction. Additionally, it offers an insightful exploration of CCOFs' applications in racemate resolution. Lastly, this review highlights the current challenges and future prospects for their further development and utilization.

show abstract

“…Homochiral organic frameworks have been prepared from metalated tetrakis(4-bromophenyl)porphyrin and S-(+)-2-methylpiperazine through Pd coupling (Scheme 4A) [60]. A similar synthesis strategy was used to obtain chiral frameworks from cyanuric chloride and (2S,5S)-2,5-dimethylpiperazine (Scheme 4B) [61].…”

Section: Post-synthetic Modification With Chiral Moietiesmentioning

confidence: 99%

Chiral Porous Organic Frameworks: Synthesis, Chiroptical Properties, and Asymmetric Organocatalytic Applications

et al. 2023

View full text Add to dashboard Cite

Chiral porous organic frameworks have emerged in the last decade as candidates for heterogeneous asymmetric organocatalysis. This review aims to provide a summary of the synthetic strategies towards the design of chiral organic materials, the characterization techniques used to evaluate their chirality, and their applications in asymmetric organocatalysis. We briefly describe the types of porous organic frameworks, including crystalline (covalent organic frameworks, COFs) and amorphous (conjugated microporous polymers, CMPs; covalent triazine frameworks, CTFs and porous aromatic frameworks, PAFs) materials. Furthermore, the strategies reported to incorporate chirality in porous organic materials are presented. We finally focus on the applications of chiral porous organic frameworks in asymmetric organocatalytic reactions, summarizing and categorizing all the available literature in the field.

show abstract

Chiral covalent triazine framework CC-DMP CCTF@SiO₂ core–shell microspheres used for HPLC enantioseparation

Abstract: Chiral covalent triazine frameworks(CCTFs), as an emerging chiral organic porous polymer materials, have many special properties, such as rich in nitrogen, large surface area, adjustable porosity, and high chemical stability,...

Cited by 8 publications

References 43 publications

Recent progress for chiral stationary phases based on chiral porous materials in high‐performance liquid chromatography and gas chromatography separation

Recent progress for chiral stationary phases based on chiral porous materials in high‐performance liquid chromatography and gas chromatography separation

Chiral Covalent Organic Frameworks as Promising Materials for Racemate Resolution

Chiral Porous Organic Frameworks: Synthesis, Chiroptical Properties, and Asymmetric Organocatalytic Applications

Contact Info

Product

Resources

About

Chiral covalent triazine framework CC-DMP CCTF@SiO2 core–shell microspheres used for HPLC enantioseparation

Abstract: Chiral covalent triazine frameworks(CCTFs), as an emerging chiral organic porous polymer materials, have many special properties, such as rich in nitrogen, large surface area, adjustable porosity, and high chemical stability,...

Cited by 8 publications

References 43 publications

Recent progress for chiral stationary phases based on chiral porous materials in high‐performance liquid chromatography and gas chromatography separation

Recent progress for chiral stationary phases based on chiral porous materials in high‐performance liquid chromatography and gas chromatography separation

Chiral Covalent Organic Frameworks as Promising Materials for Racemate Resolution

Chiral Porous Organic Frameworks: Synthesis, Chiroptical Properties, and Asymmetric Organocatalytic Applications

Contact Info

Product

Resources

About

Chiral covalent triazine framework CC-DMP CCTF@SiO₂ core–shell microspheres used for HPLC enantioseparation