Chiral CQD-based PL and CD sensors for high sensitive and selective detection of heavy metal ions

Fan, Xingang; Jiang, Li; Liu, Yan; Sun, Wei; Qin, Yingxi; Liao, Lei; Qin, Aimiao

doi:10.1016/j.optmat.2023.113620

Cited by 14 publications

(9 citation statements)

References 49 publications

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“…Biosensors can detect ions such as Ag, Hg, Cu, and Sn, among many others, ,, which are essential for physiological processes and medical diagnostics. Gao et al prepared l -aspartic acid ( l -Asp) modified Ch-CDs by a one-step hydrothermal method using citric acid as the carbon source with good stability at different concentrations of ionic intensity, temperature, and pH conditions, as shown in Figure A–D.…”

Section: Application Of Ch-cds In Biomedical Engineeringmentioning

confidence: 99%

“…However, this study can only detect one metal ion, whereas often qualitative and quantitative detection of multiple ions is required in biomedical applications. Fan et al conferred chirality to CQDs synthesized from sugar cane molasses with l / d -cysteine, and both fluorescence intensity and fluorescence quantum yields were enhanced nearly 3-fold compared to CQDs. The recognition assays for various ions showed that Ag + , Hg 2+ , and Cu 2+ undergo a fluorescence quenching mechanism with the chiral CQDs, and all show peak signals at specific wavelengths, especially for Ag ions with high sensitivity.…”

Section: Application Of Ch-cds In Biomedical Engineeringmentioning

confidence: 99%

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Recent Progress on Chiral Carbon Dots: Synthetic Strategies and Biomedical Applications

Chen,

Yu,

et al. 2023

ACS Biomater. Sci. Eng.

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The discovery of chiral carbon dots (Ch-CDs) has opened up an exciting new research direction in the field of carbon dots. It not only retains the chirality of the precursor and exhibits highly symmetric chiral optical properties but also has properties such as chemical stability, antibacterial and antitumor properties, and good biocompatibility of carbon dots. Based on these advantages, the application of Ch-CDs in the biomedical field has attracted significant interest among researchers. However, a comprehensive review of the selection of precursors for Ch-CDs, preparation methods, and applications in biomedical fields is still lacking. Here, we summarize their precursor selection and preparation methods based on recent reports on Ch-CDs and provide the first comprehensive review for specific applications in biomedical engineering, such as biosensing, bioimaging, drug carriers, antibacterial and antibiofilm, and enzyme activity modulation. Finally, we discuss application prospects and challenges that need to be overcome. We hope this review will provide valuable guidance for researchers to prepare novel Ch-CDs and facilitate their application in biomedical engineering.

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Section: Application Of Ch-cds In Biomedical Engineeringmentioning

confidence: 99%

Section: Application Of Ch-cds In Biomedical Engineeringmentioning

confidence: 99%

Recent Progress on Chiral Carbon Dots: Synthetic Strategies and Biomedical Applications

Chen,

Yu,

et al. 2023

ACS Biomater. Sci. Eng.

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“…Chiral CDs obtained by a twostep method demonstrated PL with maximum observed in the 420−490 nm spectral region. 33,34 Since the optical properties of initial CDs are preserved under treatment with chiral molecules, this method has potential for the formation of redemissive chiral CDs using achiral red-emissive CDs with chiral molecules covalently bonded to their surface. Herein, we developed bright green-and red-emissive chiral CDs based on previously reported synthesis from citric acid and urea in dimethylformamide (DMF) 35 which were then treated with chiral molecules (L-cysteine) to induce chirality in CDs.…”

mentioning

confidence: 99%

“…Similar behavior was reported for chiral CDs obtained by a two-step method with L/D-cysteine: the PL was monitored for a set of ions added (Cr 3+ , Ca 2+ , Al 3+ , Cu 2+ , Pb 2+ , Mn 2+ , Ag + , Ba 2+ , Co 2+ , Cd 2+ , Zn 2+ , Hg 2+ , Fe 3+ , Mg 2+ , and Ni 2+ ), and it was quenched only by the presence of Ag + ions. 53 These observations suggest that even with the optical response changes the developed chiral CDs are stable under metal ion addition (chiral molecules cannot be detached from their surface) and thus can be used as luminescent labels even in solutions with heavy metal ions and in a wide range of pH values.…”

mentioning

confidence: 99%

“…For this application, orange and red emissive chiral CDs were synthesized by a one-step method with PL centered at 601, 620, and 630 nm with PL quantum yield (QY) of 10.76, 6.8, and 16.2%, respectively. Chiral CDs obtained by a two-step method demonstrated PL with maximum observed in the 420–490 nm spectral region. , Since the optical properties of initial CDs are preserved under treatment with chiral molecules, this method has potential for the formation of red-emissive chiral CDs using achiral red-emissive CDs with chiral molecules covalently bonded to their surface.…”

mentioning

confidence: 99%

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Green and Red Emissive N,O-Doped Chiral Carbon Dots Functionalized with l-Cysteine

Vedernikova,

Miruschenko,

Arefina

et al. 2023

J. Phys. Chem. Lett.

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Although chirality plays an important role in the natural world, it has also attracted much scientific attention in nanotechnology, in particular, spintronics and bioapplications. Chiral carbon dots (CDs) are promising nanoparticles for sensing and bioimaging since they are biocompatible, ecofriendly, and free from toxic elements. Herein, green and red emissive chiral CDs are fabricated via surface modification treatment of achiral CDs at room temperature. After modification with L-cysteine molecules, the treated CDs demonstrate an intense chiral signal in the region of 200−300 nm with a dissymmetry factor up to 2.3 × 10 −4 and high photoluminescence quantum yields of 19% and 15% for green and red emission bands, respectively. These CDs preserve their chiral signal in different ion systems, such as those with pH changes or in the presence of metal ions, along with remarkably low cytotoxicity, making them potential candidates for use as photoluminescent labels for biological objects.

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Colloidal Chiral Carbon Dots: An Emerging System for Chiroptical Applications

Zhao,

Xie,

Tian

et al. 2024

Advanced Science

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Chiral CDots (c‐CDots) not only inherit those merits from CDots but also exhibit chiral effects in optical, electric, and bio‐properties. Therefore, c‐CDots have received significant interest from a wide range of research communities including chemistry, physics, biology, and device engineers. They have already made decent progress in terms of synthesis, together with the exploration of their optical properties and applications. In this review, the chiroptical properties and chirality origin in extinction circular dichroism (ECD) and circularly polarized luminescence (CPL) of c‐CDots is briefly discussed. Then, the synthetic strategies of c‐CDots is summarized, including one‐pot synthesis, post‐functionalization of CDots with chiral ligands, and assembly of CDots into chiral architectures with soft chiral templates. Afterward, the chiral effects on the applications of c‐CDots are elaborated. Research domains such as drug delivery, bio‐ or chemical sensing, regulation of enzyme‐like catalysis, and others are covered. Finally, the perspective on the challenges associated with the synthetic strategies, understanding the origin of chirality, and potential applications is provided. This review not only discusses the latest developments of c‐CDots but also helps toward a better understanding of the structure‐property relationship along with their respective applications.

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Chiral CQD-based PL and CD sensors for high sensitive and selective detection of heavy metal ions

Cited by 14 publications

References 49 publications

Recent Progress on Chiral Carbon Dots: Synthetic Strategies and Biomedical Applications

Recent Progress on Chiral Carbon Dots: Synthetic Strategies and Biomedical Applications

Green and Red Emissive N,O-Doped Chiral Carbon Dots Functionalized with l-Cysteine

Colloidal Chiral Carbon Dots: An Emerging System for Chiroptical Applications

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