Chiral discrimination using a quartz crystal microbalance and comparison with gas chromatographic retention data

May, Iain P.; Byfield, M. P.; Lindström, Mikael; Wünsche, Laurent

doi:10.1002/(sici)1520-636x(1997)9:3<225::aid-chir4>3.0.co;2-e

Cited by 7 publications

(6 citation statements)

References 24 publications

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“…Other terpenes such as pinene and pinane have been studied using enantioselecive QCM sensors and compared with gas chromatographic retention data [67]. It is demonstrated that enantiomeric separation was carried out using capillary columns coated with heptakis(6-O-methyl-2,3-di-O-pentyl)-β-CD, octakis(6-Omethyl-2,3-di-O-pentyl)-γ−CD, and heptakis(2,3,6-tri-Omethyl)-β-cyclodextrin.…”

Section: Cyclodextrins For Chiral Sensingmentioning

confidence: 99%

Cyclodextrin Derivatives as Chiral Supramolecular Receptors for Enantioselective Sensing

Shahgaldian

Pieles

2006

Sensors

123

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Abstract:In view of the chiral nature of many bio-molecules (and all bio-macromolecules), most of therapeutically active compounds which target these molecules need to be chiral and "good handed" to be effective. In addition to asymmetric synthetic and separation methodologies, enantioselective chemical sensors, able to distinguish between two enantiomers of the same molecule, are of relevance. In order to design these sensing tools, two major classes of enantioselective layers have been developed. The first is based on molecularly imprinted polymers which are produced (polymerized) in the presence of their target, thus the polymeric material keep in "memory" the size and the shape of this molecule and the system could be used for sensing (not reviewed here). The second approach makes use of sensitive layers containing chiral macrocyclic receptors able of stereoselective molecular recognition; these receptors are mainly based on cyclodextrins. In this contribution, are reviewed achievements in the use of native or chemically modified cyclodextrins for chiral sensing purposes (at interfaces). Potentialities of other chiral macrocycles based on calixarenes, calix-resorcinarenes or crown-ethers as supramolecular receptors for enantioselective sensing are discussed.

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Section: Cyclodextrins For Chiral Sensingmentioning

confidence: 99%

Cyclodextrin Derivatives as Chiral Supramolecular Receptors for Enantioselective Sensing

Shahgaldian

Pieles

2006

Sensors

123

View full text Add to dashboard Cite

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“…However, other platforms, such as emissive cadmium selenide [16], TSR [17,18], optical [19][20][21][22][23], field effect [24], immunological [25], and electrochemical [26][27][28][29] sensors, have been investigated. In terms of moving chromatographic chiral analysis to routine chemical sensing, the quartz crystal microbalance platform looks to be the most promising [30][31][32][33][34][35][36][37][38][39][40]. Like earlier attempts at developing chiral sensors, initial applications for the quartz crystal microbalance began with gas-phase detection [30][31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

“…In terms of moving chromatographic chiral analysis to routine chemical sensing, the quartz crystal microbalance platform looks to be the most promising [30][31][32][33][34][35][36][37][38][39][40]. Like earlier attempts at developing chiral sensors, initial applications for the quartz crystal microbalance began with gas-phase detection [30][31][32][33][34][35]. This work used cyclodextrins [30,31,34,35], and molecularly imprinted polymer (MIP) films [32,33].…”

Section: Introductionmentioning

confidence: 99%

“…Like earlier attempts at developing chiral sensors, initial applications for the quartz crystal microbalance began with gas-phase detection [30][31][32][33][34][35]. This work used cyclodextrins [30,31,34,35], and molecularly imprinted polymer (MIP) films [32,33]. Chiral selectivity based on sensor technology was compared to traditional gas chromatography [31].…”

Section: Introductionmentioning

confidence: 99%

“…This work used cyclodextrins [30,31,34,35], and molecularly imprinted polymer (MIP) films [32,33]. Chiral selectivity based on sensor technology was compared to traditional gas chromatography [31].…”

Section: Introductionmentioning

confidence: 99%

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