Chiral lanthanide NMR shift reagents and equilibria with substrate enantiomers: Rationale for the observed signals

Abstract

An analogy illustrating the two chemical equations that describe the simple view of the dynamic equilibria in which two enantiomers of substrate rapidly and reversibly bind to an optically pure lanthanide shift reagent to form two different bound complexes.

Overview of Chirality and Chiral Drugs

“…1 Chromatography with chiral stationary columns, for example, chiral highpressure liquid chromatography (HPLC) or chiral gas chromatography (GC), has also been utilized extensively for analyzing and determining enantiomeric composition of a chiral compound. Nuclear magnetic resonance (NMR) spectroscopy can also be used to evaluate the enantiomeric purity in the presence of chiral shift reagents [6,11] or through its diastereomer derivatives (e.g., Mosher's esters) [8].…”