Chiral polypeptide nanoparticles as nanoadjuvants of nanovaccines for efficient cancer prevention and therapy

Su, Yuanzhen; Xu, Weiguo; Wei, Qi; Ma, Yang; Ding, Jianxun; Chen, Xuesi

doi:10.1016/j.scib.2023.01.024

Cited by 31 publications

(17 citation statements)

References 40 publications

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“…Recently, a self‐assembled nanoadjuvant, poly( L ‐phenylalanine)‐ block ‐poly( D ‐lysine), was synthesised based on the immunogenicity of D ‐amino acids. After being complexed with ovalbumin, the nanovaccine effectively induced DC maturation and antigen presentation process 70 . Albeit highly dependent on targeted delivery systems, repurposed drugs have also been demonstrated to enhance the function of DCs and are summarised in Table 1.…”

Section: Antigen Generation Presentation Release and Capturementioning

confidence: 99%

Enhancing the anticancer immune response with the assistance of drug repurposing and delivery systems

Zhang

Gao

et al. 2023

Clinical & Translational Med

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Background The immune system plays a pivotal role in the initiation, evolution, invasion and metastasis of cancer. Therapeutics aiming at modulating or boosting anticancer immune responses have experienced immense advances during the past decades, for example, anti‐PD‐1/PD‐L1 monoclonal antibodies. Main body Concomitant with advancements in the understanding of novel mechanisms of action, conventional or emerging drugs bearing the potential to be repurposed for enhancing anticancer immunity have been identified. Meanwhile, ongoing advances in drug delivery systems enable us to utilise novel therapeutic strategies and impart drugs with fresh modes of action in tumour immunology. Conclusion Herein, we systemically review these kinds of drugs and delivery systems that can unleash the anticancer response through various aspects, including immune recognition, activation, infiltration and tumour killing. We also discuss the current caveats and future directions of these emerging strategies.

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Section: Antigen Generation Presentation Release and Capturementioning

confidence: 99%

Enhancing the anticancer immune response with the assistance of drug repurposing and delivery systems

Zhang

Gao

et al. 2023

Clinical & Translational Med

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“…[ 80 ] Moreover, chiral molecules can influence various biological behaviors, and the resulting chiral nanomaterials can serve as potent vaccine adjuvants. [ 81 ]…”

Section: Nanomaterials For Antigen‐specific Immunotherapy In Autoimmu...mentioning

confidence: 99%

“…[80] Moreover, chiral molecules can influence various biological behaviors, and the resulting chiral nanomaterials can serve as potent vaccine adjuvants. [81] With the rapid development of biologically-derived nanomaterials, antigen peptide-based cancer vaccines have gradually overcome the problems of easy degradation in the body and low targeted delivery efficiency. [82] Gao et al recently developed a nanovaccine targeting tumor-associated macrophages (TAM) and DCs, wherein MnO 2 nanoparticles were coated with the OVA antigen and mannose, which enabled the targeting of mannose receptors expressed on TAM and DC (Figure 6a).…”

Section: Cancermentioning

confidence: 99%

Regulation of Antigen‐Specific Immunotherapy with Nanomaterials

Ye,

Jia,

Ren

et al. 2023

Advanced NanoBiomed Research

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Nonspecific immunotherapies often induce general immune activation or suppression. Conversely, antigen‐specific immunotherapy, which refers to dampening or augmenting adaptive immunity against a disease‐specific antigen, increases T‐cell target specificity to pathological tissues, thereby reducing side effects on the rest of the immune system. Advances in engineering strategies for nanomaterials have enabled the feasible modulation of their physicochemical features to incorporate antigens and inherently interact with innate immune cells, which remarkably amplifies the orchestration of antigen‐specific immune responses against cancer and autoimmune diseases. From this contemporary perspective, the basic principles of antigen‐specific immunotherapy are briefly introduced and we elucidate how the latest nanoengineering paradigms regulate the functions of heterogeneous subsets of immune cells, such as antigen‐presenting cells, B cells, and regulatory or cytotoxic T cells, promoting antigen‐specific immunotherapy to treat autoimmune diseases and cancer. An outlook on prospects and remaining challenges have been discussed for, translating scientific discoveries of powerful nanomaterials into medical advances in antigen‐specific immunotherapy, thus offering new treatment modalities for patients with unmet needs.

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“…10,11 For instance, once systematically administrated, the micelles will face protein adsorption, flow and shear forces, sequestration by the mononuclear phagocytic system (MPS), and renal clearance. [12][13][14][15][16] For positively charged micelles, protein adsorption and immune cells phagocytosis are remarkably enhanced, which in turn can result in a significant loss of micelles during circulation, thus reducing the actual delivery efficiency. 17,18 Therefore, it is critical to regulate these interactions so as to address the limitations and improve the therapeutic efficacy of the micelles.…”

Section: Introductionmentioning

confidence: 99%

Effect of zwitterionic sulfobetaine incorporation on blood behaviours, phagocytosis, and in vivo biodistribution of pH-responsive micelles with positive charges

Wang,

Liu,

Lin

et al. 2024

J. Mater. Chem. B

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Chiral polypeptide nanoparticles as nanoadjuvants of nanovaccines for efficient cancer prevention and therapy

Cited by 31 publications

References 40 publications

Enhancing the anticancer immune response with the assistance of drug repurposing and delivery systems

Enhancing the anticancer immune response with the assistance of drug repurposing and delivery systems

Regulation of Antigen‐Specific Immunotherapy with Nanomaterials

Effect of zwitterionic sulfobetaine incorporation on blood behaviours, phagocytosis, and in vivo biodistribution of pH-responsive micelles with positive charges

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