Chiral recognition of Arg based on label-free PET nanochannel

Sun, Zhongyue; Zhang, Fan; Zhang, Xiaoyan; Tian, Demei; Jiang, Lei; Li, Haibing

doi:10.1039/c4cc09012h

Cited by 68 publications

(49 citation statements)

References 28 publications

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“…Such a great property is very useful for building a 4 highly sensitive and specific biosensor. Therefore, it is desirable to develop the nanochannel-based biosensor for high sensitive and specific detection of biomolecules (Sun et al, 2014;Liu et al, 2015;Sun et al, 2015;Gao et al, 2015;Wang et al, 2015;Sun et al, 2012;Xu et al, 2015;.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic nanochannels based biosensor for ultrasensitive and label-free detection of nucleic acids

Sun

Liao

Zhang

et al. 2016

Biosensors and Bioelectronics

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Section: Introductionmentioning

confidence: 99%

Biomimetic nanochannels based biosensor for ultrasensitive and label-free detection of nucleic acids

Sun

Liao

Zhang

et al. 2016

Biosensors and Bioelectronics

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“…When there were S‐Npxs in solution, the aggregated AuNPs blocked ion flux in the nanochannel with a narrow tip, which led to the decline of ionic current (presented in Figure c) . With the same principle, they also realized the chiral‐recognition by using BSA as the functional molecules in nanochannels . The chiral‐recognitions of the small biomolecules was also introduced into the selective transport for nanochannels/nanopores.…”

Section: Featuresmentioning

confidence: 97%

“…The response processes with the functional biomolecules are, thereby, confined in the nanochannels/nanopores. Sun et al added BSA as chiral probes for the recognition of analytes in the PET conical nanochannels with tip diameter of about 16 nm and base diameter of about 520 nm . In their system, the BSA just were injected in the solution shown in Figure b.…”

Section: Functionalization Techniques Of Solid‐state Ion Nanochannelsmentioning

confidence: 99%

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Biomolecule‐Functionalized Solid‐State Ion Nanochannels/Nanopores: Features and Techniques

Ding

Gao

et al. 2019

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Solid‐state ion nanochannels/nanopores, the biomimetic products of biological ion channels, are promising materials in real‐world applications due to their robust mechanical and controllable chemical properties. Functionalizations of solid‐state ion nanochannels/nanopores by biomolecules pave a wide way for the introduction of varied properties from biomolecules to solid‐state ion nanochannels/nanopores, making them smart in response to analytes or external stimuli and regulating the transport of ions/molecules. In this review, two features for nanochannels/nanopores functionalized by biomolecules are abstracted, i.e., specificity and signal amplification. Both of the two features are demonstrated from three kinds of nanochannels/nanopores: nucleic acid–functionalized nanochannels/nanopores, protein‐functionalized nanochannels/nanopores, and small biomolecule‐functionalized nanochannels/nanopores, respectively. Meanwhile, the fundamental mechanisms of these combinations between biomolecules and nanochannels/nanopores are explored, providing reasonable constructs for applications in sensing, transport, and energy conversion. And then, the techniques of functionalizations and the basic principle about biomolecules onto the solid‐state ion nanochannels/nanopores are summarized. Finally, some views about the future developments of the biomolecule‐functionalized nanochannels/nanopores are proposed.

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“…[27][28][29] Initially,f luorescence titration and infrared spectroscopy revealed that BSA has chiral selectivity toward cysteine enantiomers ( Figure S1-S3 in the Supporting Information). [27][28][29] Initially,f luorescence titration and infrared spectroscopy revealed that BSA has chiral selectivity toward cysteine enantiomers ( Figure S1-S3 in the Supporting Information).…”

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confidence: 99%

Chiral Selective Transport of Proteins by Cysteine‐Enantiomer‐Modified Nanopores

et al. 2017

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Chirality is an intriguing and intrinsic feature of life and is highly associated with many significant biological processes.H owever,w hether it influences the translocation behavior of proteins remains unclear.H erein, based on biomimetic strategies,w em ade chiral nanopores modified with cysteine enantiomers,a nd studied the chirality gating effects on protein transport. The results showt hat protein is preferentially transported through nanopores modified with lcysteine because of chiral interaction, indicating chirality strongly influences protein transport process.T his study presents an ew method for better understanding the role of chirality in selective protein transport processes and provides ac onvenient approach for studying protein chiral separation and targeted treatments.

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Chiral recognition of Arg based on label-free PET nanochannel

Abstract: Herein, we design a label-free PET nanochannel for enantioselective recognition of Arg by adding bovine serum albumin (BSA) as chiral selector. This method does not require modification on the channel surface and has applicability for fabricating other chiral sensors.

Cited by 68 publications

References 28 publications

Biomimetic nanochannels based biosensor for ultrasensitive and label-free detection of nucleic acids

Biomimetic nanochannels based biosensor for ultrasensitive and label-free detection of nucleic acids

Biomolecule‐Functionalized Solid‐State Ion Nanochannels/Nanopores: Features and Techniques

Chiral Selective Transport of Proteins by Cysteine‐Enantiomer‐Modified Nanopores

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