Chiral Resolution of Naptalam Using D-tartaric acid and Functionalized Multi-walled Carbon Nanotubes

Abstract

Chiral resolution of naptalam using various functionalized multi-walled carbon nanotubes (MWCNTs) mediated thin-lay chromatography was studied. D-tartaric acid was used as chiral selectors and cyclohexane-alcohol solvent mixture was used as developers. The results indicated that under the condition of V(cyclohexane):V(n-butanol)=30:70, the sizes of spots were even, and there is no phenomenon of tail and the effect of resolution was the best. The results indicated that chiral naptalam can be resoluted well by thin-lay chromatography impregnated with various functionalized multi-walled carbon nanotubes such as MWCNTs, aligned MWCNTs, amino functionalized MWCNTs and carboxylated MWCNTs. And the relative RF value of amino functionalized multi-walled carbon nanotubes impregnated thin-lay chromatography was significantly higher than that of other types of multi-walled carbon nanotubes impregnated thin-lay chromatography. The relative RF value of amino multi-walled carbon nanotubes mediated thin-lay chromatography was 4.32.

Semi-continuous and continuous processes for enantiomeric separation

“…An enantiomeric excess of 40% was obtained. Huang et al 116 reported the resolution of racemic α-cyclohexyl mandelic acid across microemulsion liquid membranes system using tartaric acid benzyl ester as chiral selector, sodium dodecyl sulfate as the surfactant, and mixture n -butyl alcohol and n -heptane as the organic solvents. The effect of several variables such as chiral selector concentration, pH value in the external aqueous phase, and volume ratio of the external aqueous phase to membrane phase was studied.…”