Chiral selectors in CE: Recent developments and applications (2012‐mid 2014)

Stavrou, Ioannis J.; Mavroudi, Maria; Kapnissi‐Christodoulou, Constantina P.

doi:10.1002/elps.201400310

Cited by 70 publications

(47 citation statements)

References 136 publications

(156 reference statements)

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“…Thus, it is critical to choose a suitable chiral selector (CS) to create a chiral environment. Many compounds with chiral center can be used as chiral selectors (CSs), such as cyclodextrins (CDs) [17][18][19], crown ether [20], copper-amino acid complexes [21], antibiotics [22][23][24], chiral micelles [25], and proteins [26,27]. Among these chiral selectors, natural CDs and their derivatives have been used extensively in chiral separations.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and applications of sulfopropyl ether γ-cyclodextrin polymer as chiral selector in capillary electrophoresis

Bao

Jia

et al. 2016

Anal Bioanal Chem

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A novel sulfopropyl ether γ-cyclodextrin polymer (SPE-γ-CDP) through polycondensating sulfated cyclodextrins (SCDs) was synthesized. This synthesis approach also has the potential of preparing other derived cyclodextrins (CDs) polymers. The polymerized SCDs took on both the properties of SCDs and certain characteristics of polymers, such as chiral selectivity and high viscosity. Synthesis parameters, including reactions sequence, sulfation, and polycondensation conditions were investigated systematically. The product was characterized by elemental analysis, infrared spectroscopy (IR), and indirect UV detections prior to use as background electrolytes additive. The separation conditions, including the concentration of SPE-γ-CDP, the concentration and pH of running buffer, separation voltage, as well as the additional organic solution were optimized during chiral separation of neutral, acidic, and basic enantiomers in capillary electrophoresis (CE). SPE-γ-CDP was proven to be an effective chiral resolving agent in CE with the advantages of simple synthesis process, low cost, similar ratio of charge-to-mass, low current, great reproducibility, and reusability. Graphical Abstract Synthesis and applications of sulfopropyl ether γ-cyclodextrin polymer.

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Section: Introductionmentioning

confidence: 99%

Synthesis and applications of sulfopropyl ether γ-cyclodextrin polymer as chiral selector in capillary electrophoresis

Bao

Jia

et al. 2016

Anal Bioanal Chem

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“…HPLC, SFC and CE play an irreplaceable role in separation of chiral compounds . Although numbers of various chiral selectors (CSs) for CE and chiral stationary phases (CSPs) for HPLC and SFC have been prepared and described , the synthesis and the study of the enantiorecognition mechanisms of new CSs and CSPs is still necessary.…”

Section: Introductionmentioning

confidence: 99%

The empirical comparison of cyclofructans and cyclodextrins as chiral selectors in capillary electrophoretic separation of atropisomers of R,S‐1,1’‐binaphthalene‐2,2’‐diyl hydrogen phosphate

Přibylka

Švidrnoch

Tesařová

et al. 2016

J of Separation Science

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Native cyclofructans and their isopropyl derivatives were studied as chiral selectors in capillary electrophoresis and compared with α- and β-cyclodextrin. R,S-1,1'-Binaphthalene-2,2'-diyl hydrogen phosphate was used as a model chiral compound. The empirical observation of the enantioselectivity of native cyclofructans and isopropyl derivatives of cyclofructans was described and compared with the cyclodextrins. The influence of methanol and acetonitrile, as the most commonly used organic solvents, and sodium dodecyl sulfate as a micelle forming additive on the separation of R,S-1,1'-binaphthalene-2,2'-diyl hydrogen phosphate atropisomers was achieved. The different enantiorecognition abilities resulting from unlike interaction mechanism with R,S-1,1'-binaphthalene-2,2'-diyl hydrogen phosphate were observed for the studied cyclodextrins and cyclofructans, especially when methanol or sodium dodecyl sulfate were used as modifiers of the separation conditions.

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“…CZE, with a BGE that contains CD as a CS, is the most frequently used operating mode of chiral CE . However, in some cases, utility of one single CS in a chiral separation system is not effective to achieve satisfactory separation results.…”

Section: Introductionmentioning

confidence: 99%

Combined use of l‐alanine tert butyl ester lactate and trimethyl‐β‐cyclodextrin for the enantiomeric separations of 2‐arylpropionic acids nonsteroidal anti‐inflammatory drugs

Mavroudi

Kapnissi‐Christodoulou

2015

Electrophoresis

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In this study, a new CE method, employing a binary system of trimethyl-β-CD (TM-β-CD) and a chiral amino acid ester-based ionic liquid (AAIL), was developed for the chiral separation of seven 2-arylpropionic acid nonsteroidal anti-inflammatory drugs (NSAIDs). In particular, the enantioseparation of ibuprofen, ketoprofen, carprofen, indoprofen, flurbiprofen, naproxen, and fenoprofen was improved significantly by supporting the BGE with the chiral AAIL l-alanine tert butyl ester lactate (l-AlaC4 Lac). Parameters, such as concentrations of TM-β-CD and l-AlaC4 Lac, and buffer pH, were systematically examined in order to optimize the chiral separation of each NSAID. It was observed that the addition of the AAIL into the BGE improved both resolution and efficiency significantly. After optimization of separation conditions, baseline separation (Rs >1.5) of five of the analytes was achieved in less than 11 min, while the resolution of ibuprofen and flurbiprofen was approximately 1.2. The optimized enantioseparation conditions for all analytes involve a BGE of 5 mM sodium acetate/acetic acid (pH 5.0), an applied voltage of 30 kV, and a temperature of 20°C. In addition, the results obtained by computing the %-RSD values of the EOF and the two enantiomer peaks, demonstrated excellent run-to-run, batch-to-batch, and day-to-day reproducibilities.

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Chiral selectors in CE: Recent developments and applications (2012‐mid 2014)

Cited by 70 publications

References 136 publications

Synthesis and applications of sulfopropyl ether γ-cyclodextrin polymer as chiral selector in capillary electrophoresis

Synthesis and applications of sulfopropyl ether γ-cyclodextrin polymer as chiral selector in capillary electrophoresis

The empirical comparison of cyclofructans and cyclodextrins as chiral selectors in capillary electrophoretic separation of atropisomers of R,S‐1,1’‐binaphthalene‐2,2’‐diyl hydrogen phosphate

Combined use of l‐alanine tert butyl ester lactate and trimethyl‐β‐cyclodextrin for the enantiomeric separations of 2‐arylpropionic acids nonsteroidal anti‐inflammatory drugs

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