Chiral Semiconductor Nanoparticles for Protein Catalysis and Profiling

Abstract

In this study,v ia as imple one-step method, chiral copper sulfide quantum dots (d/l-QDs) were prepared using d-/l-penicillamine (d-/l-Pen). The anisotropyfactor of d/l-QDs was as high as 0.01. The d/l-QDs can be used as photocatalysts to cleave proteins.N otably,t he l-QDs displayed the highest catalytic performance under left-circularly polarized light irradiation. Mechanistic investigations indicate the generation of hydroxylr adicals as the reactive species that cause the cutting of proteins.Chirality,which is usually based on organic molecules, [1] has been extended to inorganic nanomaterials such as metal nanoparticles (NPs), [2] carbon NPs, [3] semiconductor NPs, [4] ZnO films, [5] metaphotonic nanostructures, [6] NP assemblies with chiral geometries, [7] and so on. [8] Chiral inorganic NPs have triggered great interest due to their easy synthesis and their tremendous applications including chiral sensing, [9] chiral separation, enantioselective catalysis,a nd advanced photonic devices. [10] Recently,c hiral metal oxides (Co 3 O 4 NPs, [11] MoO 3 NPs, [12] and WO 3Àx NPs [13] ), which exhibited intense optical activities in the visible range,h ave been synthesized using chiral ligands.S ome chiral metal sulfide nanomaterials such as HgS [14] and CdS [15] have also been prepared. These chiral NPs with deformations of the crystal lattices may be extended to other nanomaterials with tailorable chiroptical properties.Nanocrystalline copper sulfide (Cu 2Àx S) is ap -type semiconductor and am aterial of particular interest due to its promising applications in biomedicine, [16] and optoelectronic conversion (photovoltaics,p hotocatalysis,a nd thermoelectrics). [17] Endowing chirality to Cu 2Àx Sn anomaterials could enable aw ider range of potential applications for chiral Cu 2Àx Si nb iology,c hemistry,a nd physics.H owever, to date,n op ublications are available on the synthesis and application of chiral Cu 2Àx Snanomaterials.Circularly polarized light (CPL), one of the most attractive chiral sources,has been used to activate chiral assemblies to probe metal ions, [18] trigger photochemical reactions, [19] and fabricate chiral nanostructures. [20] Kotov et al. reported the use of right-(left-) handed CPL to assemble racemic CdTe

Light‐Induced Chiral Iron Copper Selenide Nanoparticles Prevent β‐Amyloidopathy In Vivo

“…Because of their specific photochemical properties, chiral nanomaterials have become increasingly popular objects of research . Over the last decade, chiral nanoparticles (NPs) have been widely used in chiral catalysis, enantiospecific separation, chiral sensing, optical devices, and many other applications . More recently, chiral metal nanomaterials prepared with chiral amino acids or peptides have attracted significant attention due to their intense optical activities and good biocompatibility .…”

Ligand-induced chirality and optical activity in semiconductor nanocrystals: theory and applications

“…Kuang et al [149] reported the cleavage of BSA using Cu 2−x S QDs capped by D-/L-penicillamine, with this cleavage associated with generation of hydroxyl radicals as the reactive species. L-pen QDs displayed the highest catalytic performance under left-CPL irradiation, while D-pen QDs worked better under the right CPL irradiation.…”

Chiral Separation of rac-Propylene Oxide on Penicillamine Coated Gold NPs

“…The same is true of other chiral bio-active chemicals such as agrochemicals, pesticides and flavors. In recent years, researchers have also focused on the role of chirality in other areas such as catalysis [ 1 ], chiroptical applications [ 2 , 3 ], chiral magnetism [ 4 ], chiral semiconductors [ 5 ], cellular imaging [ 6 ], sensing [ 7 ], biomedical applications [ 8 ], chiral molecular assembly on surface [ 9 ], supramolecular chirality [ 10 ] and synthesis of chiral nanoparticles (NPs) [ 11 ]. One emerging field is chiral luminescent nanomaterials which have potential applications in chiral sensing [ 7 ].…”