Chiral separation of optically active 2,3-benzodiazepine derivatives by high performance liquid chromatography

HPLC quantitation of the four stereoisomers of benzoxathiepin derivatives with cellulose phenyl type chiral stationary phase and circular dichroism detection

“…Oxazepam was resolved on Chiralcel OJ with a mixture of n-hexane and isopropanol [22]. Baseline separation of some benzodiazepin derivatives was also obtained on the latter column with n-hexane-isoprapanol mobile phases [23].…”