Chiral separation principles in capillary electrophoresis

Gübitz, Gerald; Schmid, Martin G.

doi:10.1016/s0021-9673(97)00871-6

Cited by 231 publications

(120 citation statements)

References 284 publications

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“…Finally, enantioseparation of chiral compounds by EKC can also be achieved using neutral (dextrins and dextrans [28,29]) or charged (heparin and chondroitin sulfates [30]) polysaccharides, forming ligand-exchange complexes [31,32], or with chiral calixarenes or ergot alkaloids [32].…”

Section: Ekcmentioning

confidence: 99%

Sensitive chiral analysis by capillary electrophoresis

García-Ruiz

Marina

2006

Electrophoresis

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Sensitive chiral analysis by capillary electrophoresisIn this review, an updated view of the different strategies used up to now to enhance the sensitivity of detection in chiral analysis by CE will be provided to the readers. With this aim, it will include a brief description of the fundamentals and most of the recent applications performed in sensitive chiral analysis by CE using offline and online sample treatment techniques (SPE, liquid-liquid extraction, microdialysis, etc.), on-column preconcentration techniques based on electrophoretic principles (ITP, stacking, and sweeping), and alternative detection systems (spectroscopic, spectrometric, and electrochemical) to the widely used UV-Vis absorption detection.

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Section: Ekcmentioning

confidence: 99%

Sensitive chiral analysis by capillary electrophoresis

García-Ruiz

Marina

2006

Electrophoresis

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“…In capillary electrochromatography (CEC), which represents a recent technique, similarly to HPLC chiral stationary phases or chiral mobile phase additives can be applied. Several comprehensive reviews give a survey of chiral separation principles used in CE and applications to various compound classes [10][11][12][13][14][15][16][17].…”

Section: Capillary Electrophoresis (Ce)mentioning

confidence: 99%

“…The reader will be referred to specialized review articles for details. Several recent comprehensive reviews and book articles summarize chromatographic [3][4][5][6][7][8][9] and electrophoretic methods [10][11][12][13][14][15][16][17] for chiral separation in general.…”

Section: Introductionmentioning

confidence: 99%

Chiral separation by chromatographic and electromigration techniques. A Review

Gübitz

Schmid

2001

Biopharm & Drug Disp

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225

135

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This review gives a survey of different chiral separation principles and their use in high-performance liquid chromatography (HPLC), gas chromatography (GC), supercritical fluid chromatography (SFC), thin-layer chromatography (TLC), capillary electrophoresis (CE) and capillary electrochromatography (CEC) highlighting new developments and innovative techniques. The mechanisms of the different separation principles are briefly discussed and some selected applications are shown.

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“…Although chiral separations by CE have been recently reviewed in food analysis [7], drugs [4,5], peptides [8], in nonaqueous media [9,10], etc., few articles have reviewed the chiral separation of pollutants [11][12][13]. The most recent of these articles [13] reports the chiral resolution of some environmental pollutants, mainly pesticides, without compiling the published articles concerning this topic (in that paper, special emphasis was put on the influence of different parameters as type of chiral selector, pH of BGE, applied voltage, temperature, etc., on the chiral resolution).…”

Section: Introductionmentioning

confidence: 99%

Chiral analysis of pollutants and their metabolites by capillary electromigration methods

et al. 2005

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Chiral analysis of pollutants and their metabolites by capillary electromigration methodsChiral separation of enantiomers is one of the most challenging tasks for any analytical technique including CE. Since the first report in 1985 showing the great possibilities of CE for the separation of chiral compounds, the amount of publications concerning this topic has quickly increased. Although chiral electromigration methods have mainly been used for enantioseparation of drugs and pharmaceuticals, they have also been applied to analyze chiral pollutants. This article intends to provide an updated overview, including works published till January 2005, on the principal applications of CE to the chiral analysis of pollutants and their metabolites, with especial emphasis on articles published in the last 10 years. The main advantages and drawbacks regarding the use of CE for chiral separation of pollutants are addressed including some discussion on the foreseen trends of electromigration procedures applied to chiral analysis of contaminants. IntroductionSeparation of chiral compounds is an interesting and challenging topic of research in many analytical chemistry areas, especially in the biomedical, pharmaceutical, and environmental fields where pure enantiomeric forms are widely required. It is already well-known that enantiomers, in spite of their very similar structure, when exposed to an identical biological environment can show very different biological activity. Furthermore, as a general rule, when the toxicological effect of an active substance is directly related to its desired biological activity, the most active isomer is usually the most toxic one Abbreviations: Allyl-TER, 1-allylterguride; ANDSA, 7-aminonaphthalene-1,3-disulfonic acid; ANSA, 5-aminonaphthalene-1-sulfonic acid; ANTS, 8-aminonaphthalene-1,3,6-trisulfonic acid; CA, chrysanthemic acid; CM-ª-CD, carboxymethylated-g-CD; CMBA, 2-(4-chlorophenyl)-3-methylbutanoic acid; 2,2-CPPA, 2-(2-chlorophenoxy)-propionic acid; 2,3-CPPA, 2-(3-chlorophenoxy)-propionic acid; 2,4-CPPA, 2-(4-chlorophenoxy)-propionic acid; â-CD-NH 2 , 6-monodeoxy-6-monoamino-b-CD; â-CD- (NH 3 )

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Chiral separation principles in capillary electrophoresis

Cited by 231 publications

References 284 publications

Sensitive chiral analysis by capillary electrophoresis

Sensitive chiral analysis by capillary electrophoresis

Chiral separation by chromatographic and electromigration techniques. A Review

Chiral analysis of pollutants and their metabolites by capillary electromigration methods

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