Chiral Supramolecular Hydrogel Enhanced Transdermal Delivery of Sodium Aescinate to Modulate M1 Macrophage Polarization Against Lymphedema
Xueqian Wang,
Chunxiao Cui,
Xinxian Meng
et al.
Abstract:Sodium aescinate (SA) shows great potential for treating lymphedema since it can regulate the expression of cytokines in M1 macrophages, however, it is commonly administered intravenously in clinical practice and often accompanied by severe toxic side effects and short metabolic cycles. Herein, SA‐loaded chiral supramolecular hydrogels are prepared to prove the curative effects of SA on lymphedema and enhance its safety and transdermal transmission efficiency. In vitro studies demonstrate that SA‐ loaded chira… Show more
This tutorial review presents the development of advanced immunomodulatory hydrogels strategically designed to address chronic inflammation through their intrinsic properties.
This tutorial review presents the development of advanced immunomodulatory hydrogels strategically designed to address chronic inflammation through their intrinsic properties.
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