Chiral zinc complexes with terpene derivatives of ethylenediamine: synthesis and biological activity

Gur’eva, Ya. A.; Zalevskaya, O. A.; Николаева, Н. С.; Aleksandrova, Yulia; Yandulova, Ekaterina; Neganova, Margarita E.; Слепухин, П. А.; Kutchin, A. V.

doi:10.1007/s11172-022-3690-0

Cited by 4 publications

(1 citation statement)

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“…Terpenoids isolated from plant sources remain the starting material for various chemical transformations in terms of obtaining compounds with useful properties [1][2][3][4][5][6][7][8]. Terpenoid derivatives with cytotoxic, anti-inflammatory, analgesic, et al activity have been synthesized by chemical transformation [9][10][11][12][13][14][15][16]. The chemical transformation of triterpenoids makes it possible to solve various theoretical issues and search for promising ways of new biologically active compounds.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Investigation of Biological Activity of a Number of New Betulonic Acid Derivatives Containing 1,2,3-Triazole Fragments

Jalmakhanbetova,

Mukusheva,

Abdugalimov

et al. 2024

Preprint

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A number of chemical modifications were carried out in order to synthesize new compounds based on the triterpenoid betulonic acid. Triazolation reactions were carried out for the synthesis of new 1,2,3-triazole derivatives based on betulonic acid. Chemical changes were made on the carbonyl group at the C-3 position of the initial molecule and on the carboxyl and hydroxyl groups at the C-28 position. Chromatographic methods were used to separate and purify the formed products. Spectroscopic (NMR-, mass-) methods were used to establish the structure of synthesized compounds. As a result of the chemical transformations carried out, a number of new derivatives of betulonic acid were obtained. All synthesized compounds were tested for antimicrobial and cytotoxic activity. As a result, compounds with pronounced antimicrobial activity were identified.

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