Chitin/PLGA blend microspheres as a biodegradable drug delivery system: a new delivery system for protein

Mi, Fwu Long; Shyu, Shin Shing; Lin, Yi Mei; Wu, Yu Bey; Peng, Chih Kang; Tsai, Yi-Cheng

doi:10.1016/s0142-9612(03)00413-7

Cited by 137 publications

(79 citation statements)

References 32 publications

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“…Mostly natural polysaccharides have been investigated as biomaterials, such as chitosan [5,7,31], cellulose [32], collagen [33,34], and hyaluronic acid [35][36][37]. Chitin/poly(lactic acid-co-glycolic acid) (PGLA) blends [38] and starch-based blends [39,40] have been reported for protein drug delivery and tissue engineering scaffolds, respectively. A crosslinked hyaluronic acid hydrogel has been loaded with bioactive cytokines and successfully induced angiogenesis [36].…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Polysaccharide Gels for Skin Scaffolds

Juris¹,

Mueller²,

Smith³

et al. 2011

JBNB

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Section: Introductionmentioning

confidence: 99%

Biodegradable Polysaccharide Gels for Skin Scaffolds

Juris¹,

Mueller²,

Smith³

et al. 2011

JBNB

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“…They provide a moist environment at the wound bed, achieve haemostasis and absorb exudate [64]. They also reduce wound pain, lower the bio-burden of the wound, absorb proteinases and reduce odour [65,66]. Alginatebased wound dressings such as, hydrogels, electrospun mats and sponges offer many advantages including gelforming ability upon absorption of wound exudates and haemostatic capability [67,68].…”

Section: Chitosanmentioning

confidence: 99%

Biomedical Biopolymers, their Origin and Evolution in Biomedical Sciences: A Systematic Review

Yadav

Yadav²,

Shah

et al. 2015

JCDR

116

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“…This technique is frequently used with 10,[23][24][25] or without agitation 26,27 of media. From the in vitro release study (Figure 6), the sample and separate method without agitation showed an initial burst of about 7% followed by slow but nearly linear release reaching 35% in 35 days.…”

Section: E325mentioning

confidence: 99%

Development of a dialysis in vitro release method for biodegradable microspheres

2005

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The purpose of this research was to develop a simple and convenient in vitro release method for biodegradable microspheres using a commercially available dialyzer. A 25 KD MWCO Float-a-Lyzer was used to evaluate peptide diffusion at 37°C and 55°C in different buffers and assess the effect of peptide concentration. In vitro release of Leuprolide from PLGA microspheres, having a 1-month duration of action, was assessed using the dialyzer and compared with the commonly used ''sample and separate'' method with and without agitation. Peptide diffusion through the dialysis membrane was rapid at 37°C and 55°C in all buffers and was independent of peptide concentration. There was no detectable binding to the membrane under the conditions of the study. In vitro release of Leuprolide from PLGA microspheres was tri-phasic and was complete in 28 days with the dialysis technique. With the sample and separate technique, linear release profiles were obtained with complete release occurring under conditions of agitation. Diffusion through the dialysis membrane was sufficiently rapid to qualify the Float-a-Lyzer for an in vitro release system for microparticulate dosage forms. Membrane characteristics render it useful to study drug release under real-time and accelerated conditions.

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Chitin/PLGA blend microspheres as a biodegradable drug delivery system: a new delivery system for protein

Cited by 137 publications

References 32 publications

Biodegradable Polysaccharide Gels for Skin Scaffolds

Biodegradable Polysaccharide Gels for Skin Scaffolds

Biomedical Biopolymers, their Origin and Evolution in Biomedical Sciences: A Systematic Review

Development of a dialysis in vitro release method for biodegradable microspheres

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