Chitosan: A Potential Therapeutic Dressing Material for Wound Healing

Abstract

A wide variety of polymers have been used over decades for the preparation of dressing materials for wound healing applications. But the dressing materials based on polysaccharides such as chitosan (CS) have received tremendous attention of the worldwide researchers as a consequence of its important properties like anti-infectional activity, biocompatibility, biodegradability, nontoxicity to mention a few. CS helps in every phase of wound healing such as acting as barrier against microbes, absorbing exudates, accelerates the infiltration of inflammatory cells like neutrophils and helps in healing without scar formation. A reason behind the popularity of CS is that not only it can easily be processed as gels, films, fibers, and scaffolds but also can be blended with natural as well as synthetic polymers to reduce price and improve properties like mechanical, wettability, gas permeability, and handling. Apart from natural and synthetic polymers, CS is also blended with nanoparticles and growth factors to which it shows better antibacterial activity and reduce time span for wound healing. The present chapter aims to focus on feasibility of combining natural polymers, synthetic polymers, nanoparticles, and growth factors with CS for the preparation of wound dressings as basic healthcare materials for regenerative medicine.

A Novel Wound Dressing Based on Ag/Graphene Polymer Hydrogel: Effectively Kill Bacteria and Accelerate Wound Healing

“…As illustrated in Figure d, Ag5G1 hydrogel has a higher reduction degree of graphene than Ag1G1 hydrogel, therefore the former exhibits lower water absorbing capacity than the latter. Even so, the swelling ratio of Ag5G1 hydrogel containing partially reductive graphene and hydrophilic polyacrylic acid (1456%) is larger than that reported elsewhere (400% of the dressing based on polyvinyl alcohol and chitosan, 900% of the dressing composed of chitosan and pectin, and 959% of the dressing made of poly(glutamic acid) and chitosan) . In this sense, Ag5G1 hydrogel with a high enough swelling ratio meets with the requirement for effective absorption of exudates.…”

Chitosan-PVP-nano silver oxide wound dressing: In vitro and in vivo evaluation

“…Chitosan has many advantageous biological properties in the application as a wound dressing, namely biocompatibility, biodegradability, hemostatic activity, anti-infectional activity and property to accelerate wound-healing [1][2][3][4][5][6][7]. Chitosan influence positively in to various steps of complex wound healing process.…”

“…The blends of chitosan and PVP have already studied for antibacterial activity [14], biocompatibility [15] and biomedical applications [16]. NMR and FTIR analyses proved that hydrogen bonding was present between the chitosan and PVP [17][18][19][20].…”

Hemostasis mechanism and applications of N-alkylated chitosan sponge

“…Chitosan (CHI) is a natural polymer. It has been widely used for hemostatic applications due to its excellent biocompatibility and biodegradable properties, along with its antimicrobial and hemostatic activities . However, pure CHI is typically modified for applications because pure CHI has poor water solubility.…”