Chitosan/alginate hydrogels containing Alpha-tocopherol for wound healing in rat model

Ehterami, Arian; Salehi, Majid; Farzamfar, Saeed; Samadian, Hadi; Vaez, Ahmad; Ghorbani, Sadegh; Ai, Jafar; Sahrapeyma, Hamed

doi:10.1016/j.jddst.2019.02.032

Cited by 163 publications

(108 citation statements)

References 45 publications

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“…In recent decades, several natural and synthetic polymers have been used for wound healing such as CS [122,123], gelatin [124,125], hyaluronic acid [126], and poly vinyl alcohol [127]. Among these polymers, CSs are extensively being employed as skin regeneration components in dermal TE because of the property of hemostasis which improves tissue reproduction and induces collagen formation of fibroblasts and antibacterial activity [128][129][130][131][132][133][134][135][136]. CS in the shape of cotton fiber could improve wound healing by escalating the penetration rate of polymorphonuclear (PMN) cells at the wound site.…”

Section: Skin Regenerationmentioning

confidence: 99%

Three-Dimensional Printing Constructs Based on the Chitosan for Tissue Regeneration: State of the Art, Developing Directions and Prospect Trends

et al. 2020

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Chitosan (CS) has gained particular attention in biomedical applications due to its biocompatibility, antibacterial feature, and biodegradability. Hence, many studies have focused on the manufacturing of CS films, scaffolds, particulate, and inks via different production methods. Nowadays, with the possibility of the precise adjustment of porosity size and shape, fiber size, suitable interconnectivity of pores, and creation of patient-specific constructs, 3D printing has overcome the limitations of many traditional manufacturing methods. Therefore, the fabrication of 3D printed CS scaffolds can lead to promising advances in tissue engineering and regenerative medicine. A review of additive manufacturing types, CS-based printed constructs, their usages as biomaterials, advantages, and drawbacks can open doors to optimize CS-based constructions for biomedical applications. The latest technological issues and upcoming capabilities of 3D printing with CS-based biopolymers for different applications are also discussed. This review article will act as a roadmap aiming to investigate chitosan as a new feedstock concerning various 3D printing approaches which may be employed in biomedical fields. In fact, the combination of 3D printing and CS-based biopolymers is extremely appealing particularly with regard to certain clinical purposes. Complications of 3D printing coupled with the challenges associated with materials should be recognized to help make this method feasible for wider clinical requirements. This strategy is currently gaining substantial attention in terms of several industrial biomedical products. In this review, the key 3D printing approaches along with revealing historical background are initially presented, and ultimately, the applications of different 3D printing techniques for fabricating chitosan constructs will be discussed. The recognition of essential complications and technical problems related to numerous 3D printing techniques and CS-based biopolymer choices according to clinical requirements is crucial. A comprehensive investigation will be required to encounter those challenges and to completely understand the possibilities of 3D printing in the foreseeable future.

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Section: Skin Regenerationmentioning

confidence: 99%

Three-Dimensional Printing Constructs Based on the Chitosan for Tissue Regeneration: State of the Art, Developing Directions and Prospect Trends

et al. 2020

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“…Weight loos of the dressings was measured as the function of degradation based on our previous study [38]. Briefly, proper amount of dressings were weighted (W 0 ), incubated in PBS solution, extracted for the solution after 7 and 14 days, and precisely weighted (W 1 ).…”

Section: Weight Loss Measurementmentioning

confidence: 99%

“…The water uptake ability of the mats was measured based on our previous studies [38,39]. The dry dressing was weighted (W0), immersed in distilled water at room temperature for 24 h, and then the wet samples were weighted again (W1).…”

Section: Water Uptake Ratio Evaluationmentioning

confidence: 99%

Electrospun cellulose acetate/gelatin nanofibrous wound dressing containing berberine for diabetic foot ulcer healing: in vitro and in vivo studies

Samadian

Ehterami

Farzamfar

et al. 2019

Preprint

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Functional dressing with tailored physicochemical and biological properties is vital for diabetic foot ulcer (DFU) treatment. Our main objective in the current study was to fabricate Cellulose Acetate/Gelatin (CA/Gel) electrospun nanofibrous mat loaded with berberine (Beri) as the DFU dressing. The results demonstrated that the diameter of the nanofibers was around 502 nm, the tensile strength, contact angle, porosity, water vapor permeability, and water uptake ratio of CA/Gel nanofibers were around 2.83 MPa, 58.07, 78.17 %, 11.23 mg/cm2 hr, and 12.78 respectively, while these values for CA/Gel/Beri nanofibers were 2.69 ± 0.05 MPa, 56.93 ± 1, 76.17 ± 0.76 %, 10.17 ± 0.21 mg/cm2 hr, 14.37 ± 0.42 respectively. The bacterial evaluations demonstrated that the dressings are an excellent barrier against bacterial penetration with potent antibacterial activity. The animal studies depicted that the collagen density and angiogenesis score in the CA/Gel/Beri treated group were 88.8±6.7 % and 19.8±3.8, respectively. These findings implied that the incorporation of berberine did not compromise the physical properties of dressing, while improving the biological activates. In conclusion, our findings implied that the prepared mat is a proper wound dressing for DFU management and treatment.

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“…The treatment by using natural polymers comprising chitosan (CS), propolis and starch have been exclusively considered for the wide variety of illnesses [24][25][26][27]. Chitosan, (1-4)-2-amino-2-deoxy-β-dglucan (Scheme 1b), is a polysaccharide gained from alkaline hydrolysis of chitin with that possesses plentiful proper features for wound dressing applications [25,26,28]. Moreover, the non-toxic products of CS, after degradation, are oligosaccharides which can be then extruded or combined to glycosaminoglycans and glycoproteins [26].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the non-toxic products of CS, after degradation, are oligosaccharides which can be then extruded or combined to glycosaminoglycans and glycoproteins [26]. CS is a natural water-insoluble polymer that extensively applied for wound healing owing to several advantages including, excellent water absorption capacity, biodegradability, biocompatibility and antibacterial activity [28,29]. Thanks to mentioned-properties, chitosan can be exclusively used for the preparation of new products for wound dressing applications [26].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial wound dressing nanofibrous mats composed of cellulose acetate loaded with chitosan/erythromycin nanoparticles

Doostan

Maleki

Doostan

et al. 2020

Preprint

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This study attempts to fabricate the antibacterial nanofibrous mats composed of cellulose acetate (CA) nanofibers loaded with erythromycin-chitosan nanoparticles (Ery-CS NPs) intended for infected wound dressing. The Ery-loaded CS NPs were prepared by ionic gelation process and then incorporated into the CA electrospun nanofibers (NFs). The characterization of the NPs and mats were investigated by using dynamic light scattering (DLS), scanning electron microscopy (SEM), Attenuated Total Reflection Fourier transform infrared (ATR-FTIR) to show the size distribution, morphology and surface chemistry along with other physiochemical properties including hydrophilicity property, porosity, and water absorption capacity. The antimicrobial activity and cell viability of fibroblast cells were also evaluated. The results indicated that Ery was loaded into CS NPs with high encapsulation efficiency (95%). The CA NFs (17%) incorporated with the Ery-CS NPs (12 wt%) displayed smooth homogenous morphology with 141.7 ± 91.7 nm average diameter. The relevant analyses revealed that the NPs incorporated in NFs and provided high water holding capacity with high porosity. Finally, Ery-CS NPs/CA mats were able to inhibit the growth of both Gram-positive and Gram-negative bacteria as well as showed no cytotoxic effect on the human dermal fibroblast cells. Overall, our findings concluded that the proposed system could be potentially applied as the proper antibacterial mats for infected wound dressing applications.

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Chitosan/alginate hydrogels containing Alpha-tocopherol for wound healing in rat model

Cited by 163 publications

References 45 publications

Three-Dimensional Printing Constructs Based on the Chitosan for Tissue Regeneration: State of the Art, Developing Directions and Prospect Trends

Three-Dimensional Printing Constructs Based on the Chitosan for Tissue Regeneration: State of the Art, Developing Directions and Prospect Trends

Electrospun cellulose acetate/gelatin nanofibrous wound dressing containing berberine for diabetic foot ulcer healing: in vitro and in vivo studies

Antibacterial wound dressing nanofibrous mats composed of cellulose acetate loaded with chitosan/erythromycin nanoparticles

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