Chitosan‐alginate PEC membrane as a wound dressing: Assessment of incisional wound healing

Wang, Lishan; Khor, Eugene; Wee, Aileen; Lim, Lee Yong

doi:10.1002/jbm.10382

Cited by 283 publications

(185 citation statements)

References 17 publications

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“…[50][51][52][53] Most uses of alginate have been in the form of beads, microbeads, block gels with other shapes, fibers, and freestanding films.…”

Section: 5-10mentioning

confidence: 99%

Nanoscale eluting coatings based on alginate/chitosan hydrogels

Peng¹,

Voelcker²,

Kumar³

et al. 2007

Biointerphases

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The localized availability of bioactive biomolecules directly at the implant/tissue interface presents a promising strategy for improved wound healing and thus biointegration. Bioactive molecules that cannot be incorporated into the bulk material of a device may be delivered from a compatible surface coating, while the reservoir capacity of thin surface coatings is limited, they offer localized delivery over the first few critical hours or days of wound healing. In this study an alginate/chitosan hydrogel has been utilized as the basis for nanoscale eluting coatings to provide a hydrophilic yet water insoluble surface delivery system. The release characteristics of these hydrogel coatings were measured by employing the model molecules-fluorescein isothiocyanate dextran ͓FD; molecular weights ͑MWs͒ 4, 70, and 2000 kDa͔, fluorescein isothiocyanate albumin, and rhodamine. Scanning electron microscopy and atomic force microscopy were used to study the morphology of the hydrogel coatings on model substrates, and ellipsometry was employed for measuring the coating thickness. On silicon wafers, the coatings were of good uniformity and conformal, with a thickness of ϳ120 nm and a rms roughness of 3.0 nm. A model porous substrate, paper, which afforded deep pore penetration of the hydrogel, was used to mimic hydroxyapatite. The release of FD was observed to be dependent on the MW, the release medium, charge, and surface roughness. Sustained release was recorded for FD 70 and FD 2000 with yields of about 90% and 75%, respectively, into simulated body fluid within 26 days. Concurrent elution of different molecules from one hydrogel coating was demonstrated. The observed elution profiles were fitted to release kinetics such as the Korsmeyer-Peppas model or first order release.

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“…[50][51][52][53] Most uses of alginate have been in the form of beads, microbeads, block gels with other shapes, fibers, and freestanding films.…”

Section: 5-10mentioning

confidence: 99%

Nanoscale eluting coatings based on alginate/chitosan hydrogels

Peng¹,

Voelcker²,

Kumar³

et al. 2007

Biointerphases

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show abstract

“…To each stage, many formulations, including ointments, creams, films and dressings, have been developed. [9][10][11][12][13][14] Ointments containing minocycline, which exhibited controlled release, were reported recently because minocycline is highly effective against pressure ulcer bacteria. 15) Many formulations applied to pressure ulcers possess an antibacterial function 6,7,11,12,14,15) or potential to enhance the proliferation of granulation or epidermis.…”

Section: 2)mentioning

confidence: 99%

mentioning

confidence: 99%

In Vivo Evaluation of Kumazasa Extract and Chitosan Films Containing the Extract against Deep Skin Ulcer Model in Rats

Hirose

Onishi

Sasatsu

et al. 2007

Biological & Pharmaceutical Bulletin

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In the modern era of the aging society, the number of bedridden elderly patients is increasing gradually, and many of them are troubled by pressure ulcers (decubitus ulcers), which are often serious, resulting in refractory skin ulcers. 1,2) Various dosage forms have been developed to treat skin ulcers such as pressure ulcers. [3][4][5][6] We also prepared a patch with a tamarind gum-sucrose hydrogel containing silver sulfadiazine, and demonstrated that the formulation displayed a better effect than Geben ® cream. 7,8) Generally, a pressure ulcer goes through the stages of an period of infection and necrosis, an agglutination period, and a proliferation period of granulation and epidermis in that order until cure. To each stage, many formulations, including ointments, creams, films and dressings, have been developed. [9][10][11][12][13][14] Ointments containing minocycline, which exhibited controlled release, were reported recently because minocycline is highly effective against pressure ulcer bacteria.15) Many formulations applied to pressure ulcers possess an antibacterial function 6,7,11,12,14,15) or potential to enhance the proliferation of granulation or epidermis. 4,[16][17][18] Namely, substances with such abilities and high safety can be candidates as agents for the treatment of pressure ulcers.We focused on the liquid obtained by hydrothermal extraction of Sasa veitchii (CARR.), named Kumazasa extract (KE), because the extract has been reported to exhibit various biological functions such as antibacterial action, anti-ulcer property, cell repair function and anti-tumor action. [19][20][21][22][23] It was reported that the active ingredients associated with antiinflammatory, anti-ulcer and anti-tumor functions might be polysaccharides, which are the major components of KE. 23,24) In this study, a deep skin ulcer model was induced by skin removal and subsequent frostbite as a pressure ulcer-like model in rats, 8) and used in the in vivo studies. For the formulations, chitosan (CS) was adopted as the polymer support for solid components in KE, named EXT, because CS has been found useful to protect other types of wound, 25,26) probably due to its antibacterial, immune-enhancing function etc.27-31) Naturally dried and freeze-dried chitosan films containing KE were developed as different types of dosage forms. The film types of formulations are considered to be excellent for usability. In the present studies, KE alone, the films and other clinically used formulations were examined for in vivo efficacy using the deep skin ulcer model, and histological analyses were performed for some formulations. MATERIALS AND METHODS MaterialsLiquid obtained by hydrothermal extraction of Sasa veitchii (CARR.), named Kumazasa extract (KE), which was composed of water (50%, w/w) and residual components, named EXT (50%, w/w), was supplied by Hoshi Pharmaceutical Co., Ltd. (Japan). Chitosan 1000 (deacetylation degree of 80%; viscosity grade 1200 cP at 0.5% at 20°C) was purchased from Wako Pure Chemicals Industries, Ltd., and use...

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“…Natural biopolymers, derived from naturally existent materials (e.g., chitin and chitosan from crustacean shells; cellulose from wood, etc. ), are renewable resources and possess better inherent biodegradability, biocompatibility, biofunctional motifs, and lower immunogenicity than synthetic polymers [104][105][106][107][108][109][110]. They have thus been widely used in many biomedical applications.…”

Section: Biodegradable Polymersmentioning

confidence: 99%

Biodegradable Cell-Seeded Nanofiber Scaffolds for Neural Repair

Han

Cheung

2011

Polymers

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Central and peripheral neural injuries are traumatic and can lead to loss of motor and sensory function, chronic pain, and permanent disability. Strategies that bridge the site of injury and allow axonal regeneration promise to have a large impact on restoring quality of life for these patients. Engineered materials can be used to guide axonal growth. Specifically, nanofiber structures can mimic the natural extracellular matrix, and aligned nanofibers have been shown to direct neurite outgrowth and support axon regeneration. In addition, cell-seeded scaffolds can assist in the remyelination of the regenerating axons. The electrospinning process allows control over fiber diameter, alignment, porosity, and morphology. Biodegradable polymers have been electrospun and their use in tissue engineering has been demonstrated. This paper discusses aspects of electrospun biodegradable nanofibers for neural regeneration, how fiber alignment affects cell alignment, and how cell-seeded scaffolds can increase the effectiveness of such implants.

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Chitosan‐alginate PEC membrane as a wound dressing: Assessment of incisional wound healing

Cited by 283 publications

References 17 publications

Nanoscale eluting coatings based on alginate/chitosan hydrogels

Nanoscale eluting coatings based on alginate/chitosan hydrogels

In Vivo Evaluation of Kumazasa Extract and Chitosan Films Containing the Extract against Deep Skin Ulcer Model in Rats

Biodegradable Cell-Seeded Nanofiber Scaffolds for Neural Repair

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