Chitosan‐Alginate Sponge: Preparation and Application in Curcumin Delivery for Dermal Wound Healing in Rat

Dai, Mingzhi; Zheng, XiuLing; Xu, Xu; Kong, Xianggang; Li, Xingyi; Guo, Gang; Luo, Feng; Zhao, Xia; Wei, Yu Quan; Zhang, Qian

doi:10.1155/2009/595126

Cited by 152 publications

(100 citation statements)

References 31 publications

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“…An immatured granulation tissue with many inflammatory cells and congested vessels were observed in gauze treated groups, granulation tissue and collagen alignment were more advanced in C2A2, C2A2-curcumin sponge treated wounds. Arrangement of collagen is loose in control wounds and compact in C2A2 treated wounds [60]. In the previous reported in vitro and in vivo studies, curcumin was exposed as a potential anti-inflammatory, antimicrobial, antioxidant, and accelerated wound healing activities [61][62][63].…”

Section: Wound Dressings With Chitosan and Natural Polymersmentioning

confidence: 98%

Chitosan: A Potential Therapeutic Dressing Material for Wound Healing

Archana

Dutta

2015

Springer Series on Polymer and Composite Materials

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A wide variety of polymers have been used over decades for the preparation of dressing materials for wound healing applications. But the dressing materials based on polysaccharides such as chitosan (CS) have received tremendous attention of the worldwide researchers as a consequence of its important properties like anti-infectional activity, biocompatibility, biodegradability, nontoxicity to mention a few. CS helps in every phase of wound healing such as acting as barrier against microbes, absorbing exudates, accelerates the infiltration of inflammatory cells like neutrophils and helps in healing without scar formation. A reason behind the popularity of CS is that not only it can easily be processed as gels, films, fibers, and scaffolds but also can be blended with natural as well as synthetic polymers to reduce price and improve properties like mechanical, wettability, gas permeability, and handling. Apart from natural and synthetic polymers, CS is also blended with nanoparticles and growth factors to which it shows better antibacterial activity and reduce time span for wound healing. The present chapter aims to focus on feasibility of combining natural polymers, synthetic polymers, nanoparticles, and growth factors with CS for the preparation of wound dressings as basic healthcare materials for regenerative medicine.

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Section: Wound Dressings With Chitosan and Natural Polymersmentioning

confidence: 98%

Chitosan: A Potential Therapeutic Dressing Material for Wound Healing

Archana

Dutta

2015

Springer Series on Polymer and Composite Materials

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“…The chitosan was responsible for the swelling reduction and wound healing, at the same time as the curcumin influenced the increasing growth of collagen and other connecting tissues 17,18 .…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Bamboo Based Wound Dressing Coated With Natural Extracts of Curcumin, Aloe Vera and Chitosan Enhanced With Recombinant Human Epidermal Growth Factor and in Vivo Evaluation for Wistar Albino Wounded Rats

Ramesh¹,

Prakash²,

Palaniswamy³

et al. 2017

Int. Res. J. Pharm.

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Development of natural fibres based wound dressing material coated with different compositions of aloe vera, curcumin and Chitosan enhanced with rhEGF for wound healing applications was explicate in this research work. The coated fabrics were subjected to mechanical properties, anti-bacterial test and Scanning Electron Microscopy. Justifying more on these findings, the coated fabric samples were tested for its wound healing efficacy was studied by in vivo method of wound healing using Wister Albino rats. The dorsal surface of the rat's skin was removed and created a full -thickness wound. Then the developed fabric samples loaded with rhEGF were applied over the wound surface and the wound closure was studied in equal interval of days. The formation of zone of inhibition in antibacterial test and wound closure rate in In Vivo evaluation reveals that a specified composition of natural extracts of Aloe vera, curcumin and solution of Chitosan enhanced with rhEGF reveals that coated fabric samples exhibits good antibacterial property and higher rate of wound healing nature. Hence therefore these coated fabrics can be suitable for faster wound healing process.

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“…Previous research stresses the importance of biochemical modification of biomaterial in tissue repair and regeneration [1]. Recent studies have shown that physical factors played important role in regulating cellular behavior [2].…”

mentioning

confidence: 99%

Biomaterial Surface Can Modify HUVEC Morphology and Inflammatory Response by Regulating MicroRNA Expression

Gu¹,

Tian²,

Chen³

et al. 2017

JBM

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Vascular inflammation is an important process which contributes to the pathogenesis of many cardiovascular diseases, such as atherosclerosis. MicroRNAs (miRNAs) have been revealed as novel regulators of vascular inflammation. Prior researches had shown that alterations in gene expression of human umbilical vein endothelial cells (HUVECs) associated with topographic cues. Here, we showed that poly (dimethyl siloxane) (PDMS) substrate of 10 μm width and 3 μm depth parallel microgrooves on the surface could significantly upregulate the expression of anti-inflammatory microRNAs, miR-146a and miR-181b. In addition, the results also showed that TRAF6 and importin-α3, target of miR-146a and miR-181b, respectively, were both down-regulated (P < 0.05 and P < 0.001, respectively). The expression levels of the inflammation related proteins were all significantly decreased, including VCAM-1 (P < 0.05), ICAM-1 (P < 0.001), E-selectin (P < 0.001), and MCP-1 (P < 0.05). The adhesion of the mononuclear cell line, THP-1, was significantly decreased (P < 0.05). The results revealed that morphology modified HUVEC can modulate miR-146a and miR-181b and their downstream biological functions such as decreasing inflammation, suggesting that surface microtopology may affect vascular inflammation in the setting of cardiovascular disease. These interesting findings will facilitate the optimal design of microstructured materials in tissue engineering.

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Chitosan‐Alginate Sponge: Preparation and Application in Curcumin Delivery for Dermal Wound Healing in Rat

Cited by 152 publications

References 31 publications

Chitosan: A Potential Therapeutic Dressing Material for Wound Healing

Chitosan: A Potential Therapeutic Dressing Material for Wound Healing

Development and Characterization of Bamboo Based Wound Dressing Coated With Natural Extracts of Curcumin, Aloe Vera and Chitosan Enhanced With Recombinant Human Epidermal Growth Factor and in Vivo Evaluation for Wistar Albino Wounded Rats

Biomaterial Surface Can Modify HUVEC Morphology and Inflammatory Response by Regulating MicroRNA Expression

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