Chitosan and crosslinked chitosan nanoparticles: Synthesis, characterization and their role as Pickering emulsifiers

Ribeiro, Elisa Franco; Barros-Alexandrino, Taís Téo de; Assis, O. B. G.; Cruz, Américo; Quiles, Amparo; Hernando, Isabel; Telis, Vânia Regina Nicoletti

doi:10.1016/j.carbpol.2020.116878

Cited by 89 publications

(40 citation statements)

References 42 publications

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“…These observed changes in Rq and Ra are related to the interactions between dextran‐chitosan, it may be due to the much higher molecular weight of the chitosan compared to the dextran. In other words, when the dextran concentration was relatively low (<2.0% w/v dispersion), the intramolecular spaces were not filled; whereas the increase in dextran concentration (>2.0% w/v dispersion) resulted in higher intramolecular interactions (Ribeiro et al., 2020). The same phenomenon was reported in chitosan‐based films with deep eutectic solvents by Jakubowska et al.…”

Section: Resultsmentioning

confidence: 99%

Dextran/chitosan blend film fabrication for bio‐packaging of mushrooms ( Agaricus bisporus )

Díaz‐Montes

Yáñez-Fernández

Castro‐Muñoz

2021

J. Food Process. Preserv.

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Agaricus bisporus is likely the most worldwide consumed mushroom, however, its commercial acceptability requires an attractive visual appearance for the consumer. The storage is an essential stage in controlling the physical appearance and shelf‐life of the mushrooms. In this study, films based on commercial chitosan and a dextran produced by a Leuconostoc mesenteroides strain, were fabricated and then proposed to replace commercial packing materials. The dextran/chitosan blend films were evaluated according to the dextran concentration variation (from 0.0 up to 4.0% w/v dispersion), their physicochemical, mechanical and permeability characteristics, and their functionality in the bio‐packaging of mushrooms. The results showed that the lowest dextran concentration (0.5% w/v dispersion) presented the best properties for tensile strength (2.32 MPa), elastic modulus (~6.54 MPa), water vapor permeability (4.09 g mm kPa−1 m−2 hr−1), and delayed spoilage time of mushrooms up to 28 days at 4°C. Our findings demonstrate that these biofilms can be a viable bio‐packaging alternative for preserving fresh mushrooms. Novelty impact statement In this work, we have developed new sustainable biopolymers‐based films using chitosan and dextran. The latter material was produced through biotechnological approaches using Leuconostoc mesenteroides SF3. The developed biofilms were fully characterized and later tested for the preservation of mushrooms over 28 days. Based on our findings, the application of the dextran/chitosan blend films can be viable as a bio‐packaging alternative for preserving fresh mushrooms, extending their storage and quality.

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Section: Resultsmentioning

confidence: 99%

Dextran/chitosan blend film fabrication for bio‐packaging of mushrooms ( Agaricus bisporus )

Díaz‐Montes

Yáñez-Fernández

Castro‐Muñoz

2021

J. Food Process. Preserv.

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“…The size of ChNPs must be concerned, which is related to the factors of the synthesis process, including stirring rate, temperature, and chitosan and TPP concentration [12]. Although, many researchers have fabricated ChNPs with TPP cross-linking following the pioneering work of Calvo et al and to evaluate the possible pharmaceutical applications, optimization of the synthesis parameters and the required characteristics of the resultant ChNPs is still an ongoing vital matter in this area [9,13]. These conditions not only affect the colloidal stability, drug loading, and release manner but also it can domain the level biocompatibility and toxicity of the particles in the biological tissues and environment.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Properties of Chitosan Nanoparticles CrossLinked with Tripolyphosphate

Yusefi

Kia

Sukri

et al. 2021

JRNN

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Chitosan nanoparticles (ChNPs) have been extensively examined for various biomedical applications due to their advantages include large surface area, biodegradability, and biocompatibility. The purpose of this research was to synthesize ChNPs using a simple ionic gelation technique by the interaction of low molecular weight chitosan (LMWC) and sodium tripolyphosphate (TPP) as a cross-linking agent. ChNPs, TPP, and LMWC were analysed by X-ray diffraction (XRD) and Fourier transforms infrared (FTIR) spectra that indicated the formation of ChNPs, attributing to the rearrangement of the nanoparticles after adding the TPP cross-linker into the LMWC solution. XRD analysis exhibited that ChNPs were amorphous, due to the effect of TPP cross-linker. Dynamic light scattering showed the nano-dimension of ChNPs with a hydrodynamic size of 68.50 nm. Thus, the obtained results indicated that the properties of chitosan were improved through converting it into nanoparticles using TPP initiated ionic gelation procedure.

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“…Both ZnS and Mn:ZnS samples were diluted with deionized water with the ratio factor of 1:10 ( v / v ) for (ZnS/Mn:ZnS):deionized water. The mixture was deposited onto the Cu grids covered with carbon film (200 mesh) using a disposable dropper and a standard filter paper was used to absorb the excess solvent according to Ribeiro et al [ 23 ]. Figure 3 a shows the monodispersed spherical shape ZnS particles with average particle size of 4.66 nm [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

“…These properties of QDs allow for the simultaneous application in bioimaging cancerous tissues and also act as photosensitizers in photodynamic therapy [ 22 ]. Hence, the integration of QDs as fluorescence probe in various applications such as photocatalysis, bioimaging, biosensing, biomedicine, and DDS has been boosted instead of the conventional organic luminophores due to their intrinsic ability to resist photobleaching [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Drug Release Profiles of Mitomycin C Encapsulated Quantum Dots–Chitosan Nanocarrier System for the Possible Treatment of Non-Muscle Invasive Bladder Cancer

et al. 2021

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Nanotechnology-based drug delivery systems are an emerging technology for the targeted delivery of chemotherapeutic agents in cancer therapy with low/no toxicity to the non-cancer cells. With that view, the present work reports the synthesis, characterization, and testing of Mn:ZnS quantum dots (QDs) conjugated chitosan (CS)-based nanocarrier system encapsulated with Mitomycin C (MMC) drug. This fabricated nanocarrier, MMC@CS-Mn:ZnS, has been tested thoroughly for the drug loading capacity, drug encapsulation efficiency, and release properties at a fixed wavelength (358 nm) using a UV–Vis spectrophotometer. Followed by the physicochemical characterization, the cumulative drug release profiling data of MMC@CS-Mn:ZnS nanocarrier (at pH of 6.5, 6.8, 7.2, and 7.5) were investigated to have the highest release of 56.48% at pH 6.8, followed by 50.22%, 30.88%, and 10.75% at pH 7.2, 6.5, and 7.5, respectively. Additionally, the drug release studies were fitted to five different pharmacokinetic models including pesudo-first-order, pseudo-second-order, Higuchi, Hixson–Crowell, and Korsmeyers–Peppas models. From the analysis, the cumulative MMC release suits the Higuchi model well, revealing the diffusion-controlled mechanism involving the correlation of cumulative drug release proportional to the function square root of time at equilibrium, with the correlation coefficient values (R2) of 0.9849, 0.9604, 0.9783, and 0.7989 for drug release at pH 6.5, 6.8, 7.2, and 7.5, respectively. Based on the overall results analysis, the formulated nanocarrier system of MMC synergistically envisages the efficient delivery of chemotherapeutic agents to the target cancerous sites, able to sustain it for a longer time, etc. Consequently, the developed nanocarrier system has the capacity to improve the drug loading efficacy in combating the reoccurrence and progression of cancer in non-muscle invasive bladder diseases.

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Chitosan and crosslinked chitosan nanoparticles: Synthesis, characterization and their role as Pickering emulsifiers

Cited by 89 publications

References 42 publications

Dextran/chitosan blend film fabrication for bio‐packaging of mushrooms ( Agaricus bisporus )

Dextran/chitosan blend film fabrication for bio‐packaging of mushrooms ( Agaricus bisporus )

Synthesis and Properties of Chitosan Nanoparticles CrossLinked with Tripolyphosphate

Drug Release Profiles of Mitomycin C Encapsulated Quantum Dots–Chitosan Nanocarrier System for the Possible Treatment of Non-Muscle Invasive Bladder Cancer

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