Chitosan as a barrier membrane material in periodontal tissue regeneration

Abstract

Periodontal regeneration is defined as regeneration of the tooth-supporting tissues including cementum, periodontal ligament, and alveolar bone. Guided tissue regeneration (GTR) has been demonstrated to be an effective technique to achieve periodontal regeneration. In the GTR procedures, various kinds of membranes play important roles. Chitosan, a deacetylated derivative of chitin, is biocompatible, biodegradable, and antimicrobial. It acts as hydrating agent and possesses tissue healing and osteoinducing effect. Chitosan can be easily processed into membranes, gels, nanofibers, beads, nanoparticles, scaffolds, and sponges forms and can be used in drug delivery systems. Here, we review the bioproperties of chitosan and report the progress of application of chitosan as membranes in GTR and guided bone regeneration (GBR), which indicates that chitosan could be a good substrate candidate as the materials for the GTR/GBR membranes.

Fabrication of PEO/chitosan/PCL/olive oil nanofibrous scaffolds for wound dressing applications

“…Electrospun nanofibers due to the high porosity and large specific surface (area to volume ratio) with small pore size have a good potential for the biomedical applications [1,2]. In recent years, biocompatible nanofibers have been developed for different applications such as drug delivery systems [3][4][5][6], tissue engineering [7][8][9][10], wound dressing [11][12][13][14] and biomedical applications [15,16].…”

Incorporation of aligned PCL–PEG nanofibers into porous chitosan scaffolds improved the orientation of collagen fibers in regenerated periodontium

“…The hydrophilic PCE allowed for massive infiltration of CHI into PCE mats and kept the structural integrity of the multilayered scaffold. Furthermore, the anti-inflammatory activities of CHI have been reported to decrease inflammatory root resorption and improve success rate of surgery [30,31]. Therefore, PCE was chosen as the electrospinning material and CHI as the adhesive to combine the multi-layered PCE mats together.…”

Aplicação tópica de Bexident Gengivas® vs Bexident Post® – Efeitos na cicatrização pós extração. Estudo piloto

“…Alguns autores defendem a diminuição do tempo de cicatrização quando CHI associado à CHX, devido às características indutoras da angiogénese e da cicatrização, através da formação de tecido de granulação e re -epitelização, do CHI. 18,19,20 Novos estudos são necessários, com tempos de observação mais curtos (3, 7, 15 dias) e com uma componente de análise histológica (análise da presença de células inflamatórias, tecido de granulação, fibrina, fibras de colagénio); uma maior amostra; e maior seletividade nos dentes incluídos (divisão por grupos, pois o trauma a que os tecidos estão sujeitos é diferente). A existência de um único observador também deve ser adotado.…”