Chitosan based composite scaffolds in skin wound repair: A review

Biswal, Anuradha; Purohit, Shuvendu S.; Swain, Sarat K.

doi:10.1016/j.jddst.2023.104549

Cited by 16 publications

(8 citation statements)

References 224 publications

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“…The renewability, biodegradability, biocompatibility, low-cost, and antimicrobial properties of chitosan are influential in its selection as a raw material [8,9]. The applications of chitosan include textiles [10][11][12], medical dressings/scaffolds [13][14][15][16][17][18][19][20], water/air purification materials [21][22][23][24][25][26][27], and food storage products [28][29][30][31][32]. Moreover, chitosan has a higher solubility than chitin, which is not soluble in water or chemical solvents because of the higher proportion of N-acetylglucosamine units.…”

Section: Introductionmentioning

confidence: 99%

Developments of Core/Shell Chitosan-Based Nanofibers by Electrospinning Techniques: A Review

Taokaew,

Chuenkaek

2024

Fibers

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This review is focused on the recent development of various chitosan-based nanofibers (membranes, patches, mats, and scaffolds) that have been designed into core and shell structures using emulsion and coaxial electrospinning techniques. Chitosan, a promising polysaccharide derived from natural sources, holds potential for diverse applications, including nanofiber production, aimed at fostering sustainability. Core/shell chitosan-based nanofibers offer appealing features, including drug encapsulation and sustained release capabilities, with a higher efficiency than uniaxial fibers. The fabrication of core/shell chitosan-based nanofibers, including the co-spinning agents and various spinning parameters, such as spinning voltage, needle size, spinning flow rate, distance from needle tip to collector, temperature, and humidity, is summarized in this work. The review also explores updated applications in various fields, such as textiles, medical dressings, drug release systems, filtration membranes, and food packaging. It highlights the current advancements in core/shell chitosan-based nanofibers produced via electrospinning techniques. The innovative insights presented in the recent literature and the challenges associated with these sustainable materials are thoroughly examined, offering valuable contributions to the field.

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Section: Introductionmentioning

confidence: 99%

Developments of Core/Shell Chitosan-Based Nanofibers by Electrospinning Techniques: A Review

Taokaew,

Chuenkaek

2024

Fibers

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“…In addition, it is environmentally friendly, highly biodegradable, easily obtained, making it a green, natural-source polymer material [3]. Chitosan is promising for the preparation of novel hydrogels, which are widely used in fields of medicine [4], drug delivery [5], and tissue engineering [6], especially the superiority in the field of wound healing [7,8]. Chitosan-gluconic acid conjugate hydrogels [9] under autoclaving (121 • C, 20 min) simultaneously achieved gelation of the solution and sterilization of the hydrogel, which retained favorable biological properties and was promising as wound dressings.…”

Section: Introductionmentioning

confidence: 99%

Dielectric Barrier Discharge Plasma-Assisted Preparation of Chitosan-Based Hydrogels

Liang,

Zhang,

Guo

et al. 2024

IJMS

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Chitosan is widely used in the production of various hydrogels due to its non-biological toxicity, good biocompatibility, and strong biodegradability. However, chitosan-based hydrogels have not been widely used in tissue engineering due to their poor mechanical strength, poor stability and high biotoxicity of cross-linking agents. As a green technology, low temperature plasma is rich in active groups that can be involved in various chemical reactions, such as replacing the components on the chitosan chain, contributing to the cross-linking of chitosan. In this study, a plasma-assisted preparation method of chitosan-based hydrogels was developed and the properties, including mechanics, water absorption, and degradation (or stability), were characterized and analyzed. It is proved that plasma treatment plays a significant role in improving the mechanical strength and stability of hydrogels.

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“…The process of wound healing unfolds in a sequential manner, traversing through stages of hemostasis, inflammation, proliferation, and remodeling. Notably, the inflammatory phase holds pivotal importance, as it establishes a protective immunity barrier over the wound to prevent the growth of microorganisms on its surface . This phase also initiates molecular events that facilitate wound site infiltration, effectively deterring bacterial infection and accelerating the overall healing process.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Wound Healing in Drosophila melanogaster and Mouse Models: Synergistic Effect of Bovine Serum Albumin and Graphene Quantum Dots

Purohit,

Biswal,

Mohapatra

et al. 2023

ACS Appl. Bio Mater.

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Chitosan based composite scaffolds in skin wound repair: A review

Cited by 16 publications

References 224 publications

Developments of Core/Shell Chitosan-Based Nanofibers by Electrospinning Techniques: A Review

Developments of Core/Shell Chitosan-Based Nanofibers by Electrospinning Techniques: A Review

Dielectric Barrier Discharge Plasma-Assisted Preparation of Chitosan-Based Hydrogels

In Vivo Wound Healing in Drosophila melanogaster and Mouse Models: Synergistic Effect of Bovine Serum Albumin and Graphene Quantum Dots

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