Chitosan based hybrid materials used for wound healing applications- A short review

Khan, Zulfiqar Ali; Jamil, Shahrin; Akhtar, Amna; Bashir, Muhammad Mustehsan; Yar, Muhammad

doi:10.1080/00914037.2019.1575828

Cited by 72 publications

(21 citation statements)

References 124 publications

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“…The injury encompasses endothelial cells, keratinocytes, and fibroblasts. Extracellular matrix (ECM) components, including collagen, hyaluronic acid, proteoglycans, and elastin produce a granulation tissue to substitute the original development of blood clots [17]. Many varieties of cytokines and GFs that are involved in this phase include transforming growth factor-β family (TGF-β, including TGF-β1, TGF-β2, and TGF-β3), interleukin (IL) family, and angiogenesis factors (e.g., vascular epidermal growth factors (VEGFs)), result in the formation of new tissue [18].…”

Section: Phases Of Wound Healing Processmentioning

confidence: 99%

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

et al. 2021

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Wound care is a major biomedical field that is challenging due to the delayed wound healing process. Some factors are responsible for delayed wound healing such as malnutrition, poor oxygen flow, smoking, diseases (such as diabetes and cancer), microbial infections, etc. The currently used wound dressings suffer from various limitations, including poor antimicrobial activity, etc. Wound dressings that are formulated from biopolymers (e.g., cellulose, chitin, gelatin, chitosan, etc.) demonstrate interesting properties, such as good biocompatibility, non-toxicity, biodegradability, and attractive antimicrobial activity. Although biopolymer-based wound dressings display the aforementioned excellent features, they possess poor mechanical properties. Gelatin, a biopolymer has excellent biocompatibility, hemostatic property, reduced cytotoxicity, low antigenicity, and promotes cellular attachment and growth. However, it suffers from poor mechanical properties and antimicrobial activity. It is crosslinked with other polymers to enhance its mechanical properties. Furthermore, the incorporation of antimicrobial agents into gelatin-based wound dressings enhance their antimicrobial activity in vitro and in vivo. This review is focused on the development of hybrid wound dressings from a combination of gelatin and other polymers with good biological, mechanical, and physicochemical features which are appropriate for ideal wound dressings. Gelatin-based wound dressings are promising scaffolds for the treatment of infected, exuding, and bleeding wounds. This review article reports gelatin-based wound dressings which were developed between 2016 and 2021.

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Section: Phases Of Wound Healing Processmentioning

confidence: 99%

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

et al. 2021

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“…Beside the antibacterial ability of our CS metal hybrid nanoparticles, we have also evaluated their potential capability to also promote, at the same time, skin wound healing [79]. Toward this end, we have carried out a scratch assay consisting in culturing MEF fibroblast in Petri dishes, generating a standard wound and assessing the ability of fibroblasts to heal that wound (in form of cell migration) in absence and in presence of each nanoparticle as well as of their individual constituent (Figures 6 and S4).…”

Section: Wound Healing Assaymentioning

confidence: 99%

Ionotropic Gelation-Based Synthesis of Chitosan-Metal Hybrid Nanoparticles Showing Combined Antimicrobial and Tissue Regenerative Activities

et al. 2021

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The treatment of skin wounds poses significant clinical challenges, including the risk of bacterial infection. In particular due to its antimicrobial and tissue regeneration abilities chitosan (a polymeric biomaterial obtained by the deacetylation of chitin) has received extensive attention for its effectiveness in promoting skin wound repair. On the other hand, due to their intrinsic characteristics, metal nanoparticles (e.g., silver (Ag), gold (Au) or iron oxide (Fe3O4)) have demonstrated therapeutic properties potentially useful in the field of skin care. Therefore, the combination of these two promising materials (chitosan plus metal oxide NPs) could permit the achievement of a promising nanohybrid with enhanced properties that could be applied in advanced skin treatment. In this work, we have optimized the synthesis protocol of chitosan/metal hybrid nanoparticles by means of a straightforward synthetic method, ionotropic gelation, which presents a wide set of advantages. The synthesized hybrid NPs have undergone to a full physicochemical characterization. After that, the in vitro antibacterial and tissue regenerative activities of the achieved hybrids have been assessed in comparison to their individual constituent. As result, we have demonstrated the synergistic antibacterial plus the tissue regeneration enhancement of these nanohybrids as a consequence of the fusion between chitosan and metallic nanoparticles, especially in the case of chitosan/Fe3O4 hybrid nanoparticles.

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“…Biomaterials such as lipid‐based particles, polymeric particles, and hydrogels have been using for wound healing in pre‐clinical settings 20,21 . Notably, the landscape of polymeric materials has made a huge impact in wound healing research, as evident by applications in past 20 years 22,23 . Adhesion and phagocytosis of polymeric particles by the phagocytic cells at the region of injury or the wound help in healing.…”

Section: Introductionmentioning

confidence: 99%

Alpha‐ketoglutaric acid based polymeric particles for cutaneous wound healing

Jaggarapu

Ghosh

Johnston

et al. 2023

J Biomedical Materials Res

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Metabolites are not only involved in energy pathways but can also act as signaling molecules. Herein, we demonstrate that polyesters of alpha-ketoglutararte (paKG) can be generated by reacting aKG with aliphatic diols of different lengths, which release aKG in a sustained manner. paKG polymer-based microparticles generated via emulsion-evaporation technique lead to faster keratinocyte wound closures in a scratch assay test. Moreover, paKG microparticles also led to faster wound healing responses in an excisional wound model in live mice. Overall, this study shows that paKG MPs that release aKG in a sustained manner can be used to develop regenerative therapeutic responses.

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Chitosan based hybrid materials used for wound healing applications- A short review

Cited by 72 publications

References 124 publications

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

Ionotropic Gelation-Based Synthesis of Chitosan-Metal Hybrid Nanoparticles Showing Combined Antimicrobial and Tissue Regenerative Activities

Alpha‐ketoglutaric acid based polymeric particles for cutaneous wound healing

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