Chitosan-based mucoadhesive tablets for oral delivery of ibuprofen

Sogias, Ioannis; Williams, Adrian C.; Khutoryanskiy, Vitaliy V.

doi:10.1016/j.ijpharm.2012.07.007

Cited by 102 publications

(59 citation statements)

References 25 publications

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“…Several tablets, with excellent buccoadhesive properties to release the drug locally to the buccal mucosa or oral cavity, and to obtain a systemic effect, have been developed in the recent years. Mucoadhesive tablets can be prepared both by compression of bioadhesive polymers mixed directly with drugs [72,73] or with solid solutions or dispersions of drugs in bioadhesive polymers, obtained by spray drying the solvent [74].…”

Section: Tabletsmentioning

confidence: 99%

“…Differences shown in the piroxicam release rates from the tablets were attributed to the presence of the mucoadhesive polymers and cyclodextrin complexation [77]. Dissolution of poorly water-soluble drugs was also facilitated by the use of mucoadhesive chitosan-drug complexes prepared by compression of spray dried complex powders [74]. The mucoadhesive properties of these tablets depended on the type of chitosan or its derivatives used, the method of their formulation (spraydrying vs physical co-grinding) as well as the drug loading.…”

Section: Tabletsmentioning

confidence: 99%

See 1 more Smart Citation

A focus on mucoadhesive polymers and their application in buccal dosage forms

Russo

Selmin

Baldassari

et al. 2016

Journal of Drug Delivery Science and Technology

144

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Section: Tabletsmentioning

confidence: 99%

Section: Tabletsmentioning

confidence: 99%

A focus on mucoadhesive polymers and their application in buccal dosage forms

Russo

Selmin

Baldassari

et al. 2016

Journal of Drug Delivery Science and Technology

144

View full text Add to dashboard Cite

“…The drug release rate of the tablets was affected by chitosan type, and half-acetylated chitosan tablets showed a faster release rate. The results also indicated that mucoadhesive property of the tablets was affected by DD of chitosan and substrate pH (Sogias et al 2012).…”

Section: As Matrix Of Sustained Release Tabletsmentioning

confidence: 82%

Drug Delivery Applications of Chitosan and its Derivatives

Zhang

Mao

2015

Excipient Applications in Formulation Design and Drug Delivery

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The development of drug delivery systems always goes hand in hand with the advancement of material science. The novel synthetic or natural functional materials provide opportunities to design optimal drug delivery systems. Among these, chitosan and its derivatives exhibit excellent application future because of its prominent characteristics. In this chapter, research progress of chitosan and its derivatives for drug delivery, from structure to properties, from properties to its application were overviewed. The physicochemical properties, biological properties, biodegradability, safety evaluation and structure modification of chitosan were introduced. Furthermore, applications of chitosan and its derivatives in drug delivery including as the carrier of nanoparticles and microparticles, as coating material, as matrix of hydrogels, films and sustained release tablets, as stabilizers, as absorption enhancers, were discussed. Finally, the applications of chitosan and its derivatives in different administration routes, and their advantages for gene, protein and vaccine delivery, were reviewed. The numerous successful studies on exploitation and application of chitosan and its derivatives showed promising application future of these materials in drug delivery.

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“…This method was previously used to measure the bioadhesion of polyelectrolyte complexes (Sun et al, 2010) and the particle concentration in a sample (Mao et al, 2006). In the past few years, several mucoadhesion test methods have been reported and experiments were carried out either by using animal mucosa (Hagerstrom & Edsman, 2001;Sogias et al, 2012), human gastric mucosa (Jackson et al, 2001), mucin discs manufactured by compression of mucin (Jones et al, Figure 4. The total amount of protein (a) and LDH activity (b) in BALF at 4 h after intrapulmonarily administration of various chitosan oligomers to rats.…”

Section: Mechanism Of Absorption Enhancing Effects Of Chitosan Oligommentioning

confidence: 99%

Absorption-improving effects of chitosan oligomers based on their mucoadhesive properties: a comparative study on the oral and pulmonary delivery of calcitonin

et al. 2015

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Effects of chitosan oligomers with different types and varying concentrations on the intestinal and pulmonary absorptions of calcitonin were investigated in rats by an in situ closed loop method and an in vivo pulmonary absorption experiment, respectively. Various chitosan oligomers demonstrated different efficiencies in improving the intestinal and pulmonary absorptions of calcitonin, and chitosan hexamer with the optimal concentration of 0.5% (w/v) showed the greatest absorption enhancing effect. Moreover, pharmacodynamic parameters of calcitonin after its coadministration intrapulmonarily with various chitosan oligomers were consistently larger than that in the intestinal delivery, indicating the superior potential of pulmonary administration for systemic delivery of calcitonin. Furthermore, various chitosan oligomers neither obviously increased release amounts of protein nor activities of lactate dehydrogenase (LDH) in bronchoalveolar lavage fluid (BALF), revealing the safety of these chitosan oligomers to lung tissue. In addition, bioadhesions of various chitosan oligomers were well consistent with their absorption enhancing effects in the absorption experiment, suggesting the contribution of mucoadhesive properties of chitosan oligomers to their absorption improving effects. Taken together, chitosan oligomers, especially chitosan hexamer, can effectively improve the intestinal and pulmonary absorptions of calcitonin partly due to the mucoadhesion between positive chitosan oligomers and negative mucus in the membrane.

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Chitosan-based mucoadhesive tablets for oral delivery of ibuprofen

Cited by 102 publications

References 25 publications

A focus on mucoadhesive polymers and their application in buccal dosage forms

A focus on mucoadhesive polymers and their application in buccal dosage forms

Drug Delivery Applications of Chitosan and its Derivatives

Absorption-improving effects of chitosan oligomers based on their mucoadhesive properties: a comparative study on the oral and pulmonary delivery of calcitonin

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