Chitosan based-nanoparticles and nanocapsules: Overview, physicochemical features, applications of a nanofibrous scaffold, and bioprinting

Shoueir, Kamel R.; El-Desouky, Nagwa; Rashad, Moataz M.; Ahmed, M.K.; Janowska, Izabela; El‐Kemary, Maged

doi:10.1016/j.ijbiomac.2020.11.072

Cited by 130 publications

(66 citation statements)

References 183 publications

(176 reference statements)

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“…Garg et al [52] and [53] Agnihotri et al described methods for the preparation of CS NPs and their use in drug delivery. In addition, El Shoueir et al [54] dealt with preparation methods of CS NPs and in addition, with physicochemical properties of CS. Rizwan et al [12] studied the effect of CS properties on drug release applications.…”

Section: Enhancement In Drug Delivery By Chitosan Nanoparticlesmentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

295

120

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Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

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Section: Enhancement In Drug Delivery By Chitosan Nanoparticlesmentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

295

120

View full text Add to dashboard Cite

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“…Chitosan is an environmentally and eco-friendly polymer with multipurpose applications in various fields such as agriculture, cosmetology, food, paper, pharmacy and textile industries [64][65][66][67][68] and a potent agent for the removal of toxic pollutants [69,70]. It can be used in plant production systems as a single compound or combined with other polymers and elements [68,71].…”

Section: Practical Applications Of Chitosan On Vegetable Cropsmentioning

confidence: 99%

“…Moreover, the application of nanochitosan solutions via soaking of seedlings or foliar spraying showed better results in terms of onion crop performance and nutrient use efficiency [113]. The advanced techniques in nanoparticle preparation have allowed the efficient capitalization of chitosan's beneficial effects not only in agriculture but also in the food industry through functional packaging [67,68,114]. The use of bio-nanomaterials may also find uses in smart genetic engineering in plants through the editing of plant genomes [71].…”

Section: Practical Applications Of Chitosan On Vegetable Cropsmentioning

confidence: 99%

Sustainable Agriculture Systems in Vegetable Production Using Chitin and Chitosan as Plant Biostimulants

et al. 2021

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Chitin and chitosan are natural compounds that are biodegradable and nontoxic and have gained noticeable attention due to their effective contribution to increased yield and agro-environmental sustainability. Several effects have been reported for chitosan application in plants. Particularly, it can be used in plant defense systems against biological and environmental stress conditions and as a plant growth promoter—it can increase stomatal conductance and reduce transpiration or be applied as a coating material in seeds. Moreover, it can be effective in promoting chitinolytic microorganisms and prolonging storage life through post-harvest treatments, or benefit nutrient delivery to plants since it may prevent leaching and improve slow release of nutrients in fertilizers. Finally, it can remediate polluted soils through the removal of cationic and anionic heavy metals and the improvement of soil properties. On the other hand, chitin also has many beneficial effects such as plant growth promotion, improved plant nutrition and ability to modulate and improve plants’ resistance to abiotic and biotic stressors. The present review presents a literature overview regarding the effects of chitin, chitosan and derivatives on horticultural crops, highlighting their important role in modern sustainable crop production; the main limitations as well as the future prospects of applications of this particular biostimulant category are also presented.

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“…Generally, the DLE increases with the increase of drug concentration until the maximum charged concentration is reached [27]. The DD of CS influences its solubility in aqueous acid media and so the oral bioavailability; the increase of DD being associated with a good absorption capacity [28].…”

Section: Chitosan Based Nanoparticles (Cs-nps)mentioning

confidence: 99%

Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery Nanocarriers

et al. 2021

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In recent decades, drug delivery systems (DDSs) based on nanotechnology have been attracting substantial interest in the pharmaceutical field, especially those developed based on natural polymers such as chitosan, cellulose, starch, collagen, gelatin, alginate and elastin. Nanomaterials based on chitosan (CS) or chitosan derivatives are broadly investigated as promising nanocarriers due to their biodegradability, good biocompatibility, non-toxicity, low immunogenicity, great versatility and beneficial biological effects. CS, either alone or as composites, are suitable substrates in the fabrication of different types of products like hydrogels, membranes, beads, porous foams, nanoparticles, in-situ gel, microparticles, sponges and nanofibers/scaffolds. Currently, the CS based nanocarriers are intensely studied as controlled and targeted drug release systems for different drugs (anti-inflammatory, antibiotic, anticancer etc.) as well as for proteins/peptides, growth factors, vaccines, small DNA (DNAs) and short interfering RNA (siRNA). This review targets the latest biomedical approaches for CS based nanocarriers such as nanoparticles (NPs) nanofibers (NFs), nanogels (NGs) and chitosan coated liposomes (LPs) and their potential applications for medical and pharmaceutical fields. The advantages and challenges of reviewed CS based nanocarriers for different routes of administration (oral, transmucosal, pulmonary and transdermal) with reference to classical formulations are also emphasized.

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Chitosan based-nanoparticles and nanocapsules: Overview, physicochemical features, applications of a nanofibrous scaffold, and bioprinting

Cited by 130 publications

References 183 publications

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Sustainable Agriculture Systems in Vegetable Production Using Chitin and Chitosan as Plant Biostimulants

Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery Nanocarriers

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