Chitosan based photothermal scaffold fighting against bone tumor-related complications: Recurrence, infection, and defects

Zhao, Yao; Xu, Peng; Xu, Xiaoyang; Wu, Mingzhen; Sun, Fan; Xin, Qiangwei; Zuo, Liangrui; Cao, Yang; Xia, Yuhang; Luo, Jun; Ding, Chunmei; Li, Jianshu

doi:10.1016/j.carbpol.2022.120264

Cited by 27 publications

(23 citation statements)

References 49 publications

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“…Simultaneously, its unique photothermal conversion ability can both promote bone regeneration and repair by up-regulating alkaline phosphatase (ALP) and heat shock proteins (HSP) through hyperthermia, and also killing tumor cells by increasing local temperature ( Figure 5B ) ( Qing et al, 2020 ). In this regard, a chitosan/hydroxypropyl trimethylammonium chloride chitosan/hydroxyapatite/black phosphorus (CS/HC/HA/BP) composite scaffold is designed to take advantage of these characteristics of black phosphorus, aiming to deal with the clinical problems of tumor recurrence, bone defect and chronic bone loss after bone tumor surgery ( Zhao et al, 2023 ).…”

Section: Black Phosphorusmentioning

confidence: 99%

Multifunctional inorganic biomaterials: New weapons targeting osteosarcoma

Wang

Peng

et al. 2023

Front. Mol. Biosci.

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Osteosarcoma is the malignant tumor with the highest incidence rate among primary bone tumors and with a high mortality rate. The anti-osteosarcoma materials are the cross field between material science and medicine, having a wide range of application prospects. Among them, biological materials, such as compounds from black phosphorous, magnesium, zinc, copper, silver, etc., becoming highly valued in the biological materials field as well as in orthopedics due to their good biocompatibility, similar mechanical properties with biological bones, good biodegradation effect, and active antibacterial and anti-tumor effects. This article gives a comprehensive review of the research progress of anti-osteosarcoma biomaterials.

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Section: Black Phosphorusmentioning

confidence: 99%

Multifunctional inorganic biomaterials: New weapons targeting osteosarcoma

Wang

Peng

et al. 2023

Front. Mol. Biosci.

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“…In another work of Zhao et al., antibacterial and osteogenic performance can be well‐regulated by the tuning of photothermal conditions. [ 146 ] Simultaneous antibacterial/ antitumor properties are achieved under photothermal stimulation of <50 °C, excellent osteogenesis under mild hyperthermia stimulation (≈42 °C) is subsequently realized.…”

Section: Application Of Multiscale Mineralizationmentioning

confidence: 99%

Bioinspired Multiscale Mineralization: From Fundamentals to Potential Applications

Zuo,

Yang,

Zhang

et al. 2023

Macromolecular Bioscience

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The wondrous and imaginative designs of nature have always been an inexhaustible treasure trove for material scientists. Throughout the long evolutionary process, biominerals with hierarchical structures possess some specific advantages such as outstanding mechanical properties, biological functions, and sensing performances, the formation of which (biomineralization) is delicately regulated by organic component. Provoked by the subtle structures and profound principles of nature, bioinspired functional minerals can be designed with the participation of organic molecules. Because of the designable morphology and functions, multiscale mineralization has attracted more and more attention in the areas of medicine, chemistry, biology, and material science. This review provides a summary of current advancements in this extending topic. The mechanisms underlying mineralization is first concisely elucidated. Next, several types of minerals are categorized according to their structural characteristic, as well as the different potential applications of these materials. At last, a comprehensive overview of future developments for bioinspired multiscale mineralization is given. Concentrating on the mechanism of fabrication and broad application prospects of multiscale mineralization, the hope is to provide inspirations for the design of other functional materials.

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“…One of the main advantages of PTT is that it is cost-effective and can be used for targeted therapy. By using scaffolds that are loaded with PTAs, the therapeutic efficiency can be improved, and the side effects can be reduced through precise spatiotemporal control . Xu et al used a coprecipitation method to introduce GO into tricalcium silicate (tCS) particles, resulting in the formation of tCS/GO composites.…”

Section: Application Of Photothermal Composite Scaffolds In the Treat...mentioning

confidence: 99%

Advances in the Application of Photothermal Composite Scaffolds for Osteosarcoma Ablation and Bone Regeneration

Chen,

Yang,

et al. 2023

ACS Omega

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Photothermal therapy is a promising approach to cancer treatment. The energy generated by the photothermal effect can effectively inhibit the growth of cancer cells without harming normal tissues, while the right amount of heat can also promote cell proliferation and accelerate tissue regeneration. Various nanomaterials have recently been used as photothermal agents (PTAs). The photothermal composite scaffolds can be obtained by introducing PTAs into bone tissue engineering (BTE) scaffolds, which produces a photothermal effect that can be used to ablate bone cancer with subsequent further use of the scaffold as a support to repair the bone defects created by ablation of osteosarcoma. Osteosarcoma is the most common among primary bone malignancies. However, a review of the efficacy of different types of photothermal composite scaffolds in osteosarcoma is lacking. This article first introduces the common PTAs, BTE materials, and preparation methods and then systematically summarizes the development of photothermal composite scaffolds. It would provide a useful reference for the combination of tumor therapy and tissue engineering in bone tumor-related diseases and complex diseases. It will also be valuable for advancing the clinical applications of photothermal composite scaffolds.

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Chitosan based photothermal scaffold fighting against bone tumor-related complications: Recurrence, infection, and defects

Cited by 27 publications

References 49 publications

Multifunctional inorganic biomaterials: New weapons targeting osteosarcoma

Multifunctional inorganic biomaterials: New weapons targeting osteosarcoma

Bioinspired Multiscale Mineralization: From Fundamentals to Potential Applications

Advances in the Application of Photothermal Composite Scaffolds for Osteosarcoma Ablation and Bone Regeneration

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