Chitosan-based Polymer Matrix for Pharmaceutical Excipients and Drug Delivery

Khan, Md. Iqbal Hassan; An, Xingye; Dai, Lei; Li, Hailong; Khan, Avik; Ni, Yonghao

doi:10.2174/0929867325666180927100817

Cited by 40 publications

(18 citation statements)

References 102 publications

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“…In recent years, the research on chitosan has been widely carried out in drug development and delivery (41)(42)(43)(44). It has been documented that chitosan nanoparticles have functions such as better regulation of the immune system and inhibition of tumor growth (45,46).…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Chitosan-Coated Titanium Dioxide-Embedded Paclitaxel Nanoparticles Enhance Anti-Tumor Efficacy Against Osteosarcoma

et al. 2020

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Objective: Titanium dioxide nanoparticles (TiO 2) nanoparticles have been widely explored in the prevention of cancer risk. Due to the difficult solubility of TiO 2 nanoparticles, it is essential to synthesize new surfactants to increase its bioavailability and anti-tumor activity and reduce its cytotoxicity. Furthermore, oxidative and inflammation are closely associated with the osteosarcoma risk. Chitosan has biocompatibility, antioxidant and anti-inflammatory properties. The effects of chitosan-coated TiO 2-embedded paclitaxel nanoparticles on an osteosarcoma model were explored. Methods: An osteosarcoma model was established and chitosan-coated TiO 2embedded paclitaxel nanoparticles were prepared using a freeze-drying strategy. The morphological characteristics of nanoparticles were observed using scanning electron microscopy (SEM). The physicochemical properties of nanoparticle were evaluated by X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy. The cytotoxicity was tested by using human osteoblast cells hFob1.19 and osteosarcoma cells 143B. Osteosarcoma mice were treated with PBS buffer, paclitaxel, TiO 2embedded paclitaxel and chitosan-coated TiO 2-embedded paclitaxel nanoparticles. The biomarkers of oxidative-inflammatory status, anti-tumor activities and survival rates of the model were measured. Results: XRD analysis showed that the peaks of chitosan/TiO 2 (anatase) were consistent with those of crystalline TiO 2 and broad phase of chitosan. The FTIR spectrum indicated the relevant functional groups in TiO 2. Chitosan-coated TiO 2embedded paclitaxel nanoparticles had good biocompatibility and improve antioxidant and anti-inflammatory properties in the osteosarcoma model. Chitosan-coated TiO 2embedded paclitaxel nanoparticles was less toxic to the cells hFob1.19 and more toxic to the cells 143B than TiO 2-embedded paclitaxel nanoparticles. Chitosan-coated TiO 2embedded paclitaxel nanoparticles showed significant antitumor activity and increased the survival rate of the osteosarcoma model (P < 0.05). Conclusions: Chitosan improved anti-tumor potential of TiO 2-embedded paclitaxel nanoparticles in the prevention of osteosarcoma.

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Section: Discussionmentioning

confidence: 99%

RETRACTED: Chitosan-Coated Titanium Dioxide-Embedded Paclitaxel Nanoparticles Enhance Anti-Tumor Efficacy Against Osteosarcoma

et al. 2020

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“…Moreover, no statistical similarity was demonstrated between the profiles both at pH 1.2 and 6.8. Chitosan and its derivatives are widely described as a good vehicle for enhancing the solubility and dissolution of poorly water-soluble drugs [ 3 , 41 , 42 , 43 ]. Chitosan dissolves readily in most of the acid solutions.…”

Section: Resultsmentioning

confidence: 99%

Chitosan as Valuable Excipient for Oral and Topical Carvedilol Delivery Systems

Sip

Paczkowska-Walendowska

Rosiak

et al. 2021

Pharmaceuticals

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Chitosan is a valued excipient due to its biocompatibility properties and increasing solubility of poorly water-soluble drugs. The research presented in this paper concerns the preparation of binary combinations of chitosan (deacetylated chitin) with carvedilol (beta-blocker) to develop a formulation with a modified carvedilol release profile. As part of the research, six physical mixtures of chitosan with carvedilol were obtained and identified by spectral (PXRD, FT-IR, and Raman), thermal (DSC), and microscopic (SEM) methods. The next stage of the research estimated the profile changes and the dissolution rate for carvedilol in the obtained drug delivery systems; the reference sample was pure carvedilol. The studies were conducted at pH = 1.2 and 6.8, simulating the gastrointestinal tract conditions. Quantitative changes of carvedilol were determined using the developed isocratic UHPLC-DAD method. Established apparent permeability coefficients proved the changes in carvedilol’s permeability after introducing a drug delivery system through membranes simulating the gastrointestinal tract and skin walls. A bioadhesive potential of carvedilol–chitosan systems was confirmed using the in vitro model. The conducted research and the obtained results indicate a significant potential of using chitosan as an excipient in modern oral or epidermal drug delivery systems of carvedilol.

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“…Notulae Botanicae Horti Cluj-Napoca Agrobotanici 2 Chitosan is extracted from chitin found in the exoskeleton of crustaceans (Fournier et al, 2020), fungal cell wall (Chang et al, 2019), insect cuticle (Luo et al, 2019), among others. Chitosan has been used in waste water treatment (Uragami et al, 2015), cosmetology (Aranaz et al, 2018), medicine (Ahsan et al, 2018), pharmaceutics (Khan et al, 2019), food and beverage (Rocha et al, 2017), and paper industries (Song et al, 2018), among others.…”

Section: Academicpresmentioning

confidence: 99%

A biopolymer with antimicrobial properties and plant resistance inducer against phytopathogens: Chitosan

Torres-Rodríguez¹,

Reyes-Pérez

Castellanos³

et al. 2021

Not Bot Horti Agrobo

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Some synthetic fungicides have been currently prohibited due to their adverse effects; thus, searching for alternatives to decrease their application is a priority worldwide. An alternative to the application of synthetic fungicides is chitosan -a natural biopolymer- because of its biocompatibility, biodegradability, and bioactivity. Chitosan has been used in different industries, such as cosmetology, pharmaceutics, food, among others. In agriculture, it has been used as a resistance inductor and bio-fungicide because of its antimicrobial activity and for plant development as growth promoter. Although many works have been published on chitosan for its characteristics and mode of action, the direct effects on agriculture -both in plant and fruit phytopathogens- have not been reported. Therefore, the objective of this review is to summarize recent advances and achievements of chitosan application in agriculture with special attention to its antimicrobial properties and plant defence induction mechanisms.

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Chitosan-based Polymer Matrix for Pharmaceutical Excipients and Drug Delivery

Cited by 40 publications

References 102 publications

RETRACTED: Chitosan-Coated Titanium Dioxide-Embedded Paclitaxel Nanoparticles Enhance Anti-Tumor Efficacy Against Osteosarcoma

RETRACTED: Chitosan-Coated Titanium Dioxide-Embedded Paclitaxel Nanoparticles Enhance Anti-Tumor Efficacy Against Osteosarcoma

Chitosan as Valuable Excipient for Oral and Topical Carvedilol Delivery Systems

A biopolymer with antimicrobial properties and plant resistance inducer against phytopathogens: Chitosan

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