Chitosan Based Scaffolds and Their Applications in Wound Healing

Ahmed, Shakeel; Ikram, Saiqa

doi:10.1016/j.als.2016.04.001

Cited by 359 publications

(235 citation statements)

References 65 publications

(43 reference statements)

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“…Chitosan has found diverse applications in regenerative medicine, orthopedics, periodontology, drug delivery systems, wound healing and tissue engineering [9,10]. However, chitosan low mechanical resistance limits its application in tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

“…It is isolated from exoskeleton of insects, arthropods and crustaceans (crabs lobsters, and shrimps). Internal shells of cephalopods, radulae of molluscs, scales of fish and lissamphibians are alternative sources of chitin [10]. Chitosan is a natural biological polymer possessing reactive amine and hydroxyl group that promotes osteoblast growth and in-vivo bone formation [9].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and Characterization of Chitosan/Gum Arabic Nanoparticles for Bone Regeneration

Ibekwe¹,

Oyatogun²,

Esan³

et al. 2017

AJMSE

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Chitosan /gum arabic nanoparticles (C/G)have been prepared by ionic gelation method. This was with a view to enhance the mechanical properties and its application as bone graft scaffold. The cowry shells were washed, dried, pulverized and subsequently sieved with mesh No. 60, size 250 µm. It was deproteinized, Chitin was isolated from the synthesis by demineralising in 0.5 M Hydrochloric acid, and subsequently deacetylated by the addition of 40% (W/V) of Sodium hydroxide to synthesize chitosan. The raw chitosan was purified using 2% (v/v) acetic acid solution. The synthesized chitosan and gum arabic, a product of Acacia tree, were used to prepare chitosan/gum arabic nanoparticles by ionic gelation method. Mechanical characterization was carried out on the synthesized material using universal testing machine. Analysis of the chemical composition was carried out using Fourier transform infrared spectrometer (FTIR) and X-Ray fluorescence, (XRF). Furthermore, the morphology of the materials were studied using scanning electron microscopy, SEM and the dimension of the nanoparticles were characterized using transmission electron microscopy (TEM). Finally, an attempt was made to ascertain its suitability for bone regeneration. The FTIR spectra result confirmed that the nanoparticle was actually a derivative of chitosan by the observed shift in the peak 3462 to 3404cm- -1 and 712 cm -1 on C/G nanoparticles spectrum were similar to the native chitosan spectrum which shows that there was no change in the main backbone of chitosan structure. The scanning electron microscopy (SEM) study revealed chitosan as polymeric rods, while the chitosan /gum arabic nanoparticles in aggregate. The TEM was to confirm nanoparticles of average size of 200nm. The ultimate compressive strength was found to have increased by 78.21%, the Young Modulus by 54.4 % and percentage elongation by 7%. In overall assessment, mechanical properties of the chitosan/gum arabic nanoparticles were better than native chitosan. The study concluded that crosslinking of chitosan with gum arabic to form its nanoparticles derivative improved the mechanical properties of chitosan and consequently its application as a bone graft substitute for bone regeneration.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Chitosan/Gum Arabic Nanoparticles for Bone Regeneration

Ibekwe¹,

Oyatogun²,

Esan³

et al. 2017

AJMSE

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“…It progresses through a series of stages in which several cellular and matrix components act together to reestablish the damaged and replacement of lost tissues [23]. Chitosan-based nanomaterials, produced in varying formulations like composite scaffolds, chitosan based sponges, immobilized scaffolds and drug loaded scaffolds etc, have been used in a number of woundhealing applications [24].…”

Section: Chitosan Nano In Wound-healing Applicationsmentioning

confidence: 99%

Chitosan Based Nanoparticles towards Biomedical Applications

Laskar¹,

Rauf²

2017

JNMR

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This review outlines the bioapplications of newly developed chitosan based nanoparticles. Over the last decade, much interest has been developed in biopolymer based materials due to their biocompatible, biodegradable, nontoxic and non-allergenic nature. Here, we review the recent scientific advances in chitosan based nanoparticles not only for cancer therapy but also for various biomedical applications. An overview of chitosan, its derivatives and the formation of chitosan nanoparticles is provided along with the inherent and specific therapeutic efficacy. Major progresses in drug delivery approaches and gene delivery as well as tissue engineering applications have been summarized.

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“…Chitin is the most widely available mucopolysaccharides naturally after cellulose in terms of the amount of production each year through the process of biosynthesis [10]. Structure of chitosan (chitin are acylated) is very similar to cellulose, but their utilization is still less than the cellulose, especially because it is not able to react chemically [11].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of poly (lactic acid)/chitosan nanocomposites based on renewable resources as biobased-material

Suryani

Agusnar

Wirjosentono

et al. 2018

J. Phys.: Conf. Ser.

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Abstract. Biobased becomes one of the new breakthrough in the smart engineering, especially in biomedical applications, such as tissue engineering that serves as a supporting physical structure to trigger the growth of skin tissue. From various studies which had been done, it was known that the optimal Biobased healed wounds or injuries in a relatively short time. In this study, a Biobased natural polymer based e.g Poly(Lactic Acid) (PLA)/Chitosan Nanocomposites was made. PLA was synthesized from saba banana (Musa acuminata) as raw material using Ring-Opening Polymerization (ROP) method. PLA was mixed with Chitosan with Chitosan concentration variations of 1%, 3%, and 5% to form a nanocomposites. The analysis result showed that Chitosan concentration in PLA/Chitosan Nanocomposites sample affected the value of tensile strength. The highest value of tensile strength was obtained on a sample of 100 ml volume with a concentration of 3%, which was 120.396 MPa. The highest percentage of elongation was obtained in 100 ml volume sample with 5% concentration, which was 26.3686%. In the hydrophilicity test, the highest percentage of water absorption was obtained in a 200 ml volume sample with 5% concentration, which was 44.615%. The addition of Chitosan to the sample affected the functional group bonding, where there was a functional group of NH2 at the wave number of 2923.92 cm -1 . The sample characteristics based on water absorption indicated that the sample was potentially to be used as Biobased construction material.

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Chitosan Based Scaffolds and Their Applications in Wound Healing

Cited by 359 publications

References 65 publications

Synthesis and Characterization of Chitosan/Gum Arabic Nanoparticles for Bone Regeneration

Synthesis and Characterization of Chitosan/Gum Arabic Nanoparticles for Bone Regeneration

Chitosan Based Nanoparticles towards Biomedical Applications

Synthesis and characterization of poly (lactic acid)/chitosan nanocomposites based on renewable resources as biobased-material

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