Chitosan-based Schiff bases: Promising materials for biomedical and industrial applications

Pawariya, Varun; De, Soumik; Dutta, Joydeep

doi:10.1016/j.carbpol.2023.121395

Cited by 29 publications

(5 citation statements)

References 182 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This reduction in cell viability may be caused by the release of ADSCs from the ADSCs-containing scaffolds. The acknowledged biocompatibility of chitosan can be primarily attributed to the electrostatic attractive force between the positively charged amino groups on chitosan chains and the negatively charged cell membranes 35 . SCS is produced through the chemical modification of the C-2 and C-6 positions of the pyranose ring on chitosan, involving a β-linked d-glucosamine and N-acetyl-d-glucosamine copolymer 36 .…”

Section: Discussionmentioning

confidence: 99%

Sulfated Chitosan Nanofibrous Scaffolds Seeded With Adipose Stem Cells Promote Ischemic Wound Healing in a Proangiogenic Strategy

Zhang,

Jiao,

Shen

et al. 2024

Cell Transplant

View full text Add to dashboard Cite

Ischemic wounds are chronic wounds with poor blood supply that delays wound reconstruction. To accelerate wound healing and promote angiogenesis, adipose-derived stem cells (ADSCs) are ideal seed cells for stem cell–based therapies. Nevertheless, providing a favorable environment for cell proliferation and metabolism poses a substantial challenge. A highly sulfated heparin-like polysaccharide 2-N, 6-O-sulfated chitosan (26SCS)-doped poly(lactic-co-glycolic acid) scaffold (S-PLGA) can be used due to their biocompatibility, mechanical properties, and coagent 26SCS high affinity for growth factors. In this study, a nano-scaffold system, constructed from ADSCs seeded on electrospun fibers of modified PLGA, was designed to promote ischemic wound healing. The S-PLGA nanofiber membrane loaded with adipose stem cells ADSCs@S-PLGA was prepared by a co-culture in vitro, and the adhesion and compatibility of cells on the nano-scaffolds were explored. Scanning electron microscopy was used to observe the growth state and morphological changes of ADSCs after co-culture with PLGA electrospun fibers. The proliferation and apoptosis after co-culture were detected using a Cell Counting Kit-8 kit and flow cytometry, respectively. An ischemic wound model was then established, and we further studied the ability of ADSCs@S-PLGA to promote wound healing and angiogenesis. We successfully established ischemic wounds on the backs of rats and demonstrated that electrospun fibers combined with the biological effects of adipose stem cells effectively promoted wound healing and the growth of microvessels around the ischemic wounds. Phased research results can provide a theoretical and experimental basis for a new method for promoting clinical ischemic wound healing.

show abstract

Section: Discussionmentioning

confidence: 99%

Sulfated Chitosan Nanofibrous Scaffolds Seeded With Adipose Stem Cells Promote Ischemic Wound Healing in a Proangiogenic Strategy

Zhang,

Jiao,

Shen

et al. 2024

Cell Transplant

View full text Add to dashboard Cite

show abstract

“…For example, alginic acid and cyclodextrin could be oxidized, and the hydroxyl groups were transferred into aldehyde groups, which present some practical antimicrobial effects [24,25]. Another method is to use crosslinkers, such as chitosan or other amino-containing polymers; the amino groups could be linked with crosslinkers containing aldehyde groups [26], acyl chloride [27], or other groups so the antimicrobial moieties could be covalently bound onto the polymers.…”

Section: Approaches Toward Antimicrobial Applicationsmentioning

confidence: 99%

Dispatching Biocompatible Polymers toward Antimicrobial Applications

Tang

2024

Antimicrobial Stewardship - New Insights

View full text Add to dashboard Cite

Antimicrobial materials have become an essential part of various fields. In the past decades, various types of antimicrobial materials were developed and practically used. Based on the feedback from the clinical usage and market, the biocompatible materials have been very welcomed due to less side effects. This chapter provides a small and general review of biocompatible polymer materials and their applications in antimicrobial fields. This chapter could be divided into several parts: starting from the background introduction of microbial threats, the first section discusses the demands of biocompatible polymers for antimicrobial applications, then, the following sections would describe the basic knowledge of biocompatible polymers, including the definition, advantages, and typical examples, the next section reviewed and discussed some approaches to apply biocompatible polymers into antimicrobial applications.

show abstract

“…Numerous reviews have explored the antimicrobial potential of Schiff bases [88][89][90], as well as Schiff base-derived metal complexes [89,[91][92][93], nanoparticles and modified chitosan [90,94]. While there are reports on the antibiofilm potential of Schiff base metal complexes [95,96], there is limited information on small molecules.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, this review aims to provide a comprehensive overview of the existing scientific literature on small molecules classified as Schiff bases with antibiofilm properties. Antibiotics 2024, 13 Numerous reviews have explored the antimicrobial potential of Schiff bases [88][89][90], as well as Schiff base-derived metal complexes [89,[91][92][93], nanoparticles and modified chitosan [90,94]. While there are reports on the antibiofilm potential of Schiff base metal complexes [95,96], there is limited information on small molecules.…”

Section: Introductionmentioning

confidence: 99%

Small Schiff Base Molecules—A Possible Strategy to Combat Biofilm-Related Infections

Coandă,

Limban,

Nuță

2024

Antibiotics

View full text Add to dashboard Cite

Microorganisms participating in the development of biofilms exhibit heightened resistance to antibiotic treatment, therefore infections involving biofilms have become a problem in recent years as they are more difficult to treat. Consequently, research efforts are directed towards identifying novel molecules that not only possess antimicrobial properties but also demonstrate efficacy against biofilms. While numerous investigations have focused on antimicrobial capabilities of Schiff bases, their potential as antibiofilm agents remains largely unexplored. Thus, the objective of this article is to present a comprehensive overview of the existing scientific literature pertaining to small molecules categorized as Schiff bases with antibiofilm properties. The survey involved querying four databases (Web of Science, ScienceDirect, Scopus and Reaxys). Relevant articles published in the last 10 years were selected and categorized based on the molecular structure into two groups: classical Schiff bases and oximes and hydrazones. Despite the majority of studies indicating a moderate antibiofilm potential of Schiff bases, certain compounds exhibited a noteworthy effect, underscoring the significance of considering this type of molecular modeling when seeking to develop new molecules with antibiofilm effects.

show abstract

Chitosan-based Schiff bases: Promising materials for biomedical and industrial applications

Cited by 29 publications

References 182 publications

Sulfated Chitosan Nanofibrous Scaffolds Seeded With Adipose Stem Cells Promote Ischemic Wound Healing in a Proangiogenic Strategy

Sulfated Chitosan Nanofibrous Scaffolds Seeded With Adipose Stem Cells Promote Ischemic Wound Healing in a Proangiogenic Strategy

Dispatching Biocompatible Polymers toward Antimicrobial Applications

Small Schiff Base Molecules—A Possible Strategy to Combat Biofilm-Related Infections

Contact Info

Product

Resources

About