Chitosan-based self-assembled nanocarriers coordinated to cisplatin for cancer treatment

Trummer, Ronny; Rangsimawong, Worranan; Sajomsang, Warayuth; Kumpugdee-Vollrath, Mont; Opanasopit, Praneet; Tonglairoum, Prasopchai

doi:10.1039/c8ra03069c

Cited by 22 publications

(13 citation statements)

References 25 publications

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“…It makes the whole molecule water‐soluble through immense hydrogen bonding (electrostatic interaction) 21 . Eventually, the molecules start showing self‐assembly behavior in water with the formation of nano‐architectures microsphere, micelle, vesicles, and so on 22–25 . The thiobarbiturate attached chitosan molecules became stimuli‐responsive as well in this study.…”

Section: Introductionmentioning

confidence: 57%

Unique vesicular nano‐architecture of thiobarbiturate derived chitosan with excellent hydrophilicity

Mandal

Mukherjee

Patra

et al. 2021

Journal of Polymer Science

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The natural polymer chitosan is conjugated with hydrophilic thiobarbiturate entity which makes the whole molecule amphiphilic as well as water‐soluble. The water solubility of this molecule leads to an interesting supramolecular architecture via self‐assembly. The monomers are synthesized via Friedel Crafts alkylation and ring‐closing reaction where homopolymers derivatives undergo coupling and thiol‐ene click reaction. The monomer and the modified polymers are well characterized through conventional spectroscopic techniques. The self‐assembly behavior is then confirmed through critical aggregation concentration study and dynamic light scattering. The field emission scanning electron microscope and transmission electron microscope images provide the architectures' fascinating morphology. Finally, the loading and release of doxorubicin drug are performed to investigate the biomedical applications.

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Section: Introductionmentioning

confidence: 57%

Unique vesicular nano‐architecture of thiobarbiturate derived chitosan with excellent hydrophilicity

Mandal

Mukherjee

Patra

et al. 2021

Journal of Polymer Science

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“…Most notably, cell accumulation, cellular uptake and toxicity studies have also been conducted against liver cancer cells. Among all nanocarriers, BSCT self-assembly nanocarrier has demonstrated a sustained release of drug and also reduced the nephrotoxicity [39].…”

Section: Chitosan Nanoparticlesmentioning

confidence: 99%

Recent progress in nanotechnology-based novel drug delivery systems in designing of cisplatin for cancer therapy: an overview

Farooq

Aquib

Farooq

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

110

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2019) Recent progress in nanotechnology-based novel drug delivery systems in designing of cisplatin for cancer therapy: an overview, Artificial ABSTRACT Cisplatin cis-(diammine)dichloridoplatinum(II) (CDDP) is the first platinum-based complex approved by the food and drug administration (FDA) of the United States (US). Cisplatin is the first line chemotherapeutic agent used alone or combined with radiations or other anti-cancer agents for a broad range of cancers such as lung, head and neck. Aroplatin TM , Lipoplatin TM and SPI-077 are PEGylated liposomebased nano-formulations that are still under clinical trials. They have many limitations, for example, poor aqueous solubility, drug resistance and toxicities, which can be overcome by encapsulating the cisplatin in Nemours nanocarriers. The extensive literature from different electronic databases covers the different nano-delivery systems that are developed for cisplatin. This review critically emphasizes on the recent advancement, development, innovations and updated literature reported for different carrier systems for CDDP. ARTICLE HISTORY Current status of FDA-approved/under clinical trials CDDP nano-formulationsMany liposomal-based nano-formulations are at the stage of clinical trials. One of under clinical trials drugs, Lipoplatin (Regulon, Inc.), is liposome-based platinum formulation under Phase III clinical trials [11]. It contains a combination of cisplatin (9%) and lipids (91%(w/w)), including soy phosphatidylcholine (SPC-3), cholesterol, dipalmitoyl phosphatidyl glycerol (DPPG) and methoxy-PEG-distearoyl phosphatidyl

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“…Self-assembly of the modified chitosans into micelles in aqueous solution with hydrophobic pockets has been used to entrap various anti-tumor therapeutics such as PTX, doxorubicin, and camptothecin (Quiñones et al, 2018). Recently, Trummer et al (2018) synthesized N-benzyl-N,O-succinyl chitosan, N-naphthyl-N,O-succinyl chitosan, and N-octyl-N,O-succinyl chitosan-based self-assembled nanocarriers and successfully coordinated to antitumor drug cisplatin and evaluated the efficacy of these nanocarriers in vitro in human carcinoma cell line HN22 and HN29. The results showed high efficacy of N-benzyl-N,Osuccinyl chitosan-mediated cisplatin delivery.…”

Section: Natural Polymersmentioning

confidence: 99%

Polymeric Nano-Biomaterials for Medical Applications: Advancements in Developing and Implementation Considering Safety-By-Design Concepts

2020

Frontiers Research Topics

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The compilation of articles constituting this eBook is the property of Frontiers.Each article within this eBook, and the eBook itself, are published under the most recent version of the Creative Commons CC-BY licence.The version current at the date of publication of this eBook is CC-BY 4.0. If the CC-BY licence is updated, the licence granted by Frontiers is automatically updated to the new version.When exercising any right under the CC-BY licence, Frontiers must be attributed as the original publisher of the article or eBook, as applicable.Authors have the responsibility of ensuring that any graphics or other materials which are the property of others may be included in the CC-BY licence, but this should be checked before relying on the CC-BY licence to reproduce those materials. Any copyright notices relating to those materials must be complied with.Copyright and source acknowledgement notices may not be removed and must be displayed in any copy, derivative work or partial copy which includes the elements in question.

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Chitosan-based self-assembled nanocarriers coordinated to cisplatin for cancer treatment

Abstract: Polymeric nanocarriers were prepared using chitosan derivatives, and were coordinated to cisplatin.The nanocarrier properties and cytotoxicity on the human carcinoma cells, HN22, were investigated.

Cited by 22 publications

References 25 publications

Unique vesicular nano‐architecture of thiobarbiturate derived chitosan with excellent hydrophilicity

Unique vesicular nano‐architecture of thiobarbiturate derived chitosan with excellent hydrophilicity

Recent progress in nanotechnology-based novel drug delivery systems in designing of cisplatin for cancer therapy: an overview

Polymeric Nano-Biomaterials for Medical Applications: Advancements in Developing and Implementation Considering Safety-By-Design Concepts

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