Chitosan Based Self-assembled Nanoparticles in Drug Delivery

Quiñones, Javier Pérez; Peniche, Hazel; Péniche, Carlos

doi:10.20944/preprints201802.0012.v2

2018

DOI: 10.20944/preprints201802.0012.v2

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Chitosan Based Self-assembled Nanoparticles in Drug Delivery

Javier Pérez Quiñones¹,

Hazel Peniche²,

Carlos Péniche³

Abstract: Abstract:Chitosan is a cationic polysaccharide usually obtained by alkaline deacetylation of chitin 23Another suitable way to generate self-assembled chitosan nanoparticles is through the formation of 24 polyelectrolyte complexes with polyanions. This paper reviews the main approaches developed for

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Cited by 2 publications

References 127 publications

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Ionotropic Gelation of Chitosan Flat Structures and Potential Applications

et al. 2021

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The capability of some polymers, such as chitosan, to form low cost gels under mild conditions is of great application interest. Ionotropic gelation of chitosan has been used predominantly for the preparation of gel beads for biomedical application. Only in the last few years has the use of this method been extended to the fabrication of chitosan-based flat structures. Herein, after an initial analysis of the major applications of chitosan flat membranes and films and their usual methods of synthesis, the process of ionotropic gelation of chitosan and some recently proposed novel procedures for the synthesis of flat structures are presented.

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Ionotropic Gelation of Chitosan Flat Structures and Potential Applications

et al. 2021

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Optimized Preparation of Levofloxacin Loaded Polymeric Nanoparticles

et al. 2019

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In this work, poly(lactic-co-glycolic acid) (PLGA) and chitosan (CS) nanoparticles were synthesized with the purpose of encapsulating levofloxacin (LEV). A thorough study has been carried out in order to optimize the preparation of LEV-loaded polymeric nanoparticles (NPs) suitable for parenteral administration. Changes in the preparation method, in the organic solvent nature, in the pH of the aqueous phase, or in the temperature were investigated. To the authors´ knowledge, a systematic study in order to improve the LEV nanocarrier characteristics and the yield of drug encapsulation has not been carried out to date. The physicochemical characterization of the NPs, their encapsulation efficiency (EE), and the in vitro release of LEV revealed that the best formulation was the emulsion-solvent evaporation method using dichloromethane as organic solvent, which renders suitable LEV loaded PLGA NPs. The morphology of these NPs was investigated using TEM. Their antimicrobial activities against several microorganisms were determined in vitro measuring the minimum inhibitory concentration (MIC). The results show that the use of these loaded LEV PLGA nanoparticles has the advantage of the slow release of the antibiotic, which would permit an increase in the time period between administrations as well as to decrease the side effects of the drug.

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Chitosan Based Self-assembled Nanoparticles in Drug Delivery

Cited by 2 publications

References 127 publications

Ionotropic Gelation of Chitosan Flat Structures and Potential Applications

Ionotropic Gelation of Chitosan Flat Structures and Potential Applications

Optimized Preparation of Levofloxacin Loaded Polymeric Nanoparticles

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