Chitosan biomaterials application in dentistry

Fakhri, Elaheh; Eslami, Hosein; Maroufi, Parham; Pakdel, Farzaneh; Taghizadeh, Sepehr; Ganbarov, Khudaverdi; Yousefi, Mehdi; Tanomand, Asghar; Yousefi, Bahman; Mahmoudi, S.M.S.; Kafil, Hossein Samadi

doi:10.1016/j.ijbiomac.2020.06.211

Cited by 206 publications

(122 citation statements)

References 230 publications

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“…Nowadays, hydrogels derived from natural biomaterials, for example, the polysaccharide-based materials (such as cellulose, chitosan, etc) or the protein-based materials (such as collagen, gelatin, etc. ), have been widely used in tissue engineering [ 20 , 21 ], because of their good biocompatibility and biodegradability, extensive availability and excellent biological properties [ 20 ]. Whereas, polysaccharide-based natural materials such as chitosan has poor solubility under physiological conditions, which is the key limiting factor for its application in tissue engineering [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Application of bioactive hydrogels combined with dental pulp stem cells for the repair of large gap peripheral nerve injuries

Luo

Jin

et al. 2021

Bioactive Materials

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Due to the limitations in autogenous nerve grafting or Schwann cell transplantation, large gap peripheral nerve injuries require a bridging strategy supported by nerve conduit. Cell based therapies provide a novel treatment for peripheral nerve injuries. In this study, we first experimented an optimal scaffold material synthesis protocol, from where we selected the 10% GFD formula (10% GelMA hydrogel, recombinant human basic fibroblast growth factor and dental pulp stem cells (DPSCs)) to fill a cellulose/soy protein isolate composite membrane (CSM) tube to construct a third generation of nerve regeneration conduit, CSM-GFD. Then this CSM-GFD conduit was applied to repair a 15-mm long defect of sciatic nerve in a rat model. After 12 week post implant surgery, at histologic level, we found CSM-GFD conduit could regenerate nerve tissue like neuron and Schwann like nerve cells and myelinated nerve fibers. At physical level, CSM-GFD achieved functional recovery assessed by a sciatic functional index study. In both levels, CSM-GFD performed like what gold standard, the nerve autograft, could do. Further, we unveiled that almost all newly formed nerve tissue at defect site was originated from the direct differentiation of exogeneous DPSCs in CSM-GFD. In conclusion, we claimed that this third-generation nerve regeneration conduit, CSM-GFD, could be a promising tissue engineering approach to replace the conventional nerve autograft to treat the large gap defect in peripheral nerve injuries.

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Section: Introductionmentioning

confidence: 99%

Application of bioactive hydrogels combined with dental pulp stem cells for the repair of large gap peripheral nerve injuries

Luo

Jin

et al. 2021

Bioactive Materials

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“…Chitosan is a natural polymer possessing several beneficial properties, such as biodegradability, biocompatibility, fungicidal, antimicrobial, and antitumor activities [54][55][56][57]. It is considered a promising component of mouthwashes and denture adhesives for preventing oral candidiasis [55]. Moreover, low-molecular-weight chitosan solution can be effectively used as an antifungal denture cleanser, showing a significant reduction in C. albicans viability in biofilms formed on polymethyl methacrylate [58].…”

Section: Polymeric Materialsmentioning

confidence: 99%

Biomaterials for the Prevention of Oral Candidiasis Development

et al. 2021

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Thousands of microorganisms coexist within the human microbiota. However, certain conditions can predispose the organism to the overgrowth of specific pathogens that further lead to opportunistic infections. One of the most common such imbalances in the normal oral flora is the excessive growth of Candida spp, which produces oral candidiasis. In immunocompromised individuals, this fungal infection can reach the systemic level and become life-threatening. Hence, prompt and efficient treatment must be administered. Traditional antifungal agents, such as polyenes, azoles, and echinocandins, may often result in severe adverse effects, regardless of the administration form. Therefore, novel treatments have to be developed and implemented in clinical practice. In this regard, the present paper focuses on the newest therapeutic options against oral Candida infections, reviewing compounds and biomaterials with inherent antifungal properties, improved materials for dental prostheses and denture adhesives, drug delivery systems, and combined approaches towards developing the optimum treatment.

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“…Chitosan leitet sich von Chitin ab, das bspw. in größeren Mengen in Krabbentierschalen oder Pilzen vorkommt [41]. Chitin wird in einem komplexen chemischen Prozess in Chitosan umgewandelt.…”

Section: Fluoride Und Polyvalente Metallionenunclassified